Cover

Fight Cancer


 
 
 
 
Charles Spender
 
 
 
 Distributed by Smashwords
 ISBN: 9781311261052
 THIRD EDITION, October 3, 2020
 Copyright © 2013 Charles Spender

Table of Contents

Introduction
 
 
Scientifically proven anticancer products (turmeric, vitamin D, black seed, broccoli, and others)
 
 
Moderately cold showers are safe and cannot cause an illness
 
 
The adapted cold shower: an unstressful and easy procedure
 
 
The many benefits of adapted cold showers for cancer patients

Reduction of fatigue
 
 
Reduction of pain
 
 
Enhancement of antitumor immunity
 
 
Reduction of nausea
 
 
Improvement of mood

Rare side effects
 
 
Brief cardio exercise
 
 
Benefits of ultraviolet light
 
 
Various raw diets for losing overweight and tumors

The importance of organ meats: the pancreas, liver, and thymus

55 ways to change your lifestyle for health improvement
 
 
The Shatalova method
 
 
The Gonzalez protocol
 
 
The Revici method and similarities with the Gonzalez protocol
 
 
Fasting to lose weight and tumors
 
 
Pungent chemotherapy
 
 
Nonrecommended alternative treatments of cancer
 
 
Conclusions
 
 
APPENDIX I: 37 ways to distort the results of a clinical trial and cancer statistics
 
 
APPENDIX II: Revici's medical tests and therapeutic agents
 
 
Literature

 

Introduction

The latest version of this ebook (October 3, 2020, or later) can be downloaded in a high-quality EPUB format here or here. This booklet describes many methods for cancer treatment, all of them free of charge and based on lifestyle changes. Three of these methods are scientifically proven well but are not used by conventional medicine and are not recommended officially for cancer treatment: turmeric, physical exercise, and vitamin D. The amount of scientific evidence about the anticancer properties of these approaches is overwhelming: close to a thousand scientific papers in total (link, link). Turmeric and its active ingredient curcumin are at the top: over 600 scientific papers. The possible reason why these methods/products are not officially recommended for cancer treatment: they cannot bring profits to the healthcare industry and therefore nobody is lobbying healthcare authorities about these treatments. Another possible reason is that clinical trials testing a single method are not available for each of the above, also because of the absence of a profit motive. Therapeutic use of temporary hyperthermia (increased core body temperature or local heating) is supported by hundreds of scientific studies and is being gradually incorporated into oncological clinical practice. As explained later, the best approach to testing these modalities is simultaneous because they are a part of the hypothesis that cancer is caused by a suboptimal lifestyle in combination with genetic predisposition. It would be silly to try to identify a single active ingredient of a healthy lifestyle. Those who wish to test this hypothesis on the basis of good scientific evidence, may consider the following comprehensive lifestyle intervention: a balanced diverse diet free of vitamin and mineral supplements (the diet should not primarily consist of junk food and should contain normal proportions of protein, fat, and carbs), brief cardio exercise every day (twofold pulse acceleration), two level teaspoons of a turmeric powder daily, a tablespoon of canned cod liver daily (vitamin D), brief sun-bathing or UV-tanning sessions (1 minute on four sides, as another source of vitamin D and for other reasons), moderate hyperthermia (core body temperature 38°C) once every 2 weeks in a hot bath or as a result of intensive exercise, and daily adapted cold showers (moderate cooling is proven to reduce fatigue and is widely known to reduce pain), plus inclusion of raw broccoli into the diet (a lot of scientific papers about anticancer effectiveness of these products and their ingredients, link) along with pancreatic enzymes. Forget about killing cancer cells, the goal is to normalize metabolism and the immune system, which are expected to gradually take care of the cancer and related health problems.

I should say upfront that after many years of research in this field, in my opinion, the Gonzalez protocol (devised by Nicholas J. Gonzalez, M.D.) is the most effective treatment for many types of cancer as compared to either conventional or alternative therapies. The Gonzalez protocol is supported by scientific studies and by scientific argumentation and is described in a separate chapter toward the end of this booklet.

This booklet also offers three experimental anticancer treatments; there is no scientific proof, but there is a good and easy-to-understand scientific rationale. One of the experimental methods is already mentioned above and is designed to enhance the antitumor immune response (link) and to improve quality of life: “adapted cold shower.” The moderate repeated cooling can allow you to undertake more rounds of chemo-, radiotherapy, or surgical treatment because cooling reduces many side effects of those methods. (Note: This manual does not recommend cytotoxic chemotherapy.) This approach should improve the chances of survival. Cold showers can have rare side effects and may not be appropriate for patients with some leukemias and lymphomas.

Although the evidence of effectiveness of cold showers is currently scarce, there is plenty of indirect evidence from laboratory animals and studies on human subjects. According to a study on laboratory rats (link), repeated cooling should be effective against sarcomas and some carcinomas, but the most suitable types of tumor in humans are currently unknown. The treatment is free and safe, so it would be reasonable to try it, especially if all other options are exhausted.

In addition, the current state of science and technology allows us to safely consume raw meat, i.e., to kill virtually all bacteria and parasites while keeping the meat raw or almost raw. One of the chapters describes several benefits of safe raw meat and 100% raw diet for cancer patients. The third experimental treatment is a lifestyle that contains numerous types of hormesis. The latter means that weak stressors (harmful in large doses) improve health and extend the lifespan. For instance, a heat stroke is harmful, but a brief hot bath is beneficial for health.

The scientific hypothesis behind all these methods is that cancer is caused by an unnatural lifestyle, for example, by an unusual diet (putting the wrong kind of fuel into the gas tank), or by a lack of various mild and not-so-mild stressors that animals encounter in the wild: changes of temperature, abundant physical activity, etc. Accordingly, changing the lifestyle should normalize the patient’s metabolism and immune system and help to overcome cancer even at an advanced stage. There is some published scientific evidence that the human body can normalize cancer cells (without killing them) by means of special chemicals and peptides called antineoplastons. In addition, there are some scientific data suggesting that big changes in a lifestyle can cure cancer even at an advanced stage (link).

Radiotherapy, surgical treatment, and targeted chemotherapy may help too, but strength of evidence behind these methods is much smaller than you think (see below). This manual advises skepticism regarding cytotoxic chemotherapy (the type of chemotherapy indiscriminately killing rapidly dividing cells) because of various unethical activities and undue influence of the pharmaceutical industry. Several types of cancer (testicular cancer, gestational choriocarcinoma, Hodgkin disease, acute myelocytic leukemia, and some high-grade lymphomas) are an exception because cytotoxic chemotherapy shows extraordinary effectiveness there (which would be difficult to fake). In particular, Dr. Gonzalez recommended that patients with acute myelocytic leukemia first undertake cytotoxic chemotherapy to knock down this rapidly progressing cancer, and then they can undergo alternative treatments. In the great majority of cancer cases, cytotoxic chemotherapy shows only modest, clinically insignificant (link, link) effectiveness, which is probably unreal anyway because of various distortions and biases (for example, most of the authors receive payments from the industry, i.e., have conflicts of interest). None of the scientific evidence regarding chemotherapy should be trusted blindly (including targeted chemotherapy). The prevailing point of view is often incorrect because it has been imposed by the ruling elite for their own benefit; they can, want to, and do control all important institutions of society, usually covertly, while brainwashing you into thinking that you live in a democracy and there are no conspiracies.

At present, the way science is organized makes it easy to manipulate science by funding. To be precise, research articles usually show the results that the sponsors of the study want to see (often false results). And I don’t mean little abuses here and there: we are talking about gigantic distortions. Big sponsors can create a desired scientific consensus by sponsoring thousands of misleading studies. To give another example, the type of clinical trial that is widely believed to be the gold standard of accuracy and scientific rigor (the technical term is "double-blind randomized controlled trial") is no longer trustworthy because of numerous loopholes, approximately thirty. (See Appendix I "36 ways to distort the results...") These loopholes have been exploited for decades but came to light only recently. The official treatment guidelines based on this bad information are still in place. Furthermore, the most prestigious scientific journals are completely corrupted, and you cannot believe anything they publish now (see Appendix I, point #29).

The vast majority of surgical methods have not been proven to be beneficial. For regulatory approval, prescription drugs are tested by those who produce and sell them or by people with major conflicts of interest (such as contract research organizations). Ridiculous but true. Scientific medical journals receive lots of money for reprints and advertising from the healthcare industry. Members of editorial boards of the most prestigious medical journals receive huge payments from the healthcare industry. Seventy to 90% of scientific articles contain bad irreproducible results because of fraud, bad methodology, or both.

Almost all physicians who publish scientific articles have an unacknowledged conflict of interest: humans tend to consciously or unintentionally try to prove that their profession is important for society and to avoid criticizing one's own source of income. To give an example, experienced surgeons—who see that some procedures cause nothing but harm in some situations—will keep silent about this problem so as not to jeopardize one's source of income or incur disapproval of supervisors. The mainstream view in medicine is formed by the majority of such doctors. Silicone breast implants for instance are disliked by men and cause harm to women's health (and there is a risk of death too); in actuality, only those who earn money from these implants need these operations, and their primary tool is false advertising. As for cancer, I was unable to find any studies proving that the Whipple procedure (pancreaticoduodenectomy) improves the survival of patients with pancreatic cancer. It is possible that this expensive procedure exists solely for the benefit of those who offer it.

Virtually all scientists have an unacknowledged conflict of interest related to renewal of research grants: the scientist must prove by hook or by crook that the hypothesis declared in the initial grant application is correct; otherwise, he/she will not receive the second half of the money. This conflict of interest is probably the biggest source of scientific fraud outside the private industry. Reporting of scientific fraud is discouraged not encouraged under the present system. Private corporations such as pharmaceutical companies and medical device makers face no punishment for publishing fraudulent results in scientific journals (this activity is not monitored or regulated by the government). Many official treatment guidelines are based on bad corrupted data, such as scientific studies showing a tiny beneficial effect where the authors have conflicts of interest (such small effects are likely to be the result of the financial bias).

Modern medicine is among the leading causes of death (third place by some estimates) because of unnecessary surgical interventions, medical errors, and adverse effects of prescription drugs taken correctly. You should be skeptical about both conventional medicine and alternative medicine.

When choosing a medical procedure for any illness (not necessarily cancer), you need to ask yourself 1) Does the author of the procedure or healthcare provider want my money? Can I perform the treatment myself without paying a penny to this healthcare professional or to the inventor? 2) Does the procedure make sense or address the real ultimate cause of the illness that I can understand and verify myself? 3) Will this practitioner turn me into a permanent client of the healthcare industry because the procedure will temporarily relieve the symptoms, while causing new health problems? 4) Is the procedure dangerous: will it do more harm than good? 5) Is it likely that the scientific evidence was corrupted by those trying to sell this method? 6) Do I really have a disease that needs to be treated? 7) Is it possible that I am healthy, but the health problem was invented to sell various healthcare products? 8) If the method in question is often called “quackery,” is it possible that it works but is being trashed by powerful competitors? 9) If the treatment method in question is called useless, unproven, or “pseudoscience” in a Wikipedia article, then the method is probably safe, proven, and effective: you need to do so some research in the literature.

To learn more about imperfections of science, see the section “Interpreting evidence from studies on human subjects,” Chapter One, in my other book “How to Become Smarter.” Furthermore, cytotoxic chemotherapy does not make biological sense because it impairs the immune system, and such drugs are often carcinogens themselves. A normally functioning immune system is necessary for defeating and preventing cancer.

Most likely, there is no rigorous scientific proof that the anticancer spices/herbs and physical exercise can cure your specific type of cancer. But, a big but, the three standard cancer treatments (surgical resection, radiotherapy, and chemotherapy) are not supported by rigorous proof either, as mentioned above. Surgical methods are used out of force of habit (in most cases, there is no proof that they cause more good than harm), whereas chemotherapy and radiation therapy are supported predominantly by biased evidence (i.e., proof provided by those who sell these treatments and/or by researchers with conflicts of interest). This problem is compounded by the fact the authors of scientific articles about profitable medical treatments often fail to show their conflicts of interest (or do not show all of them), and readers will have to spend some time to search for this information on their own.

Government agencies tasked with combating cancer routinely manipulate statistics to make themselves look good. I am aware of seven such ploys (see Appendix I "36 ways to distort the results of a clinical trial and cancer statistics"). With some creative use of statistical methods, a 5-year 90% death rate can be presented as a 5-year 90% relative survival rate. In reality, if you go the conventional route, your prognosis is as dismal today as it was decades ago, with rare exceptions. Physicians have to follow official guidelines (which were installed with the help of the healthcare industry) or else they damage their career. There are many decent oncologists who care about patients and do their best to help them.

Most patients are deceived by omnipresent propaganda and become victims of the system because of the following illusions: the world is governed by the forces of good, the government serves the people, there are no conspiracies in the government, and you can definitely believe mass media. Another big fallacy is the notion that healthcare authorities exist to preserve the health of citizens and to cure them of diseases. The problems of conventional medicine are explained well here and here (scroll down for a free ebook). Because of the above-mentioned corruption of science, officially approved cancer treatments are not designed to cure cancer; typically, they kill a patient faster than a cancer would. If you want to survive, you need to stop drinking government kool-aid, and you should forget everything you've learned about cancer from mass media.

You should not blindly believe physicians because they are brainwashed starting from medschool that diseases can be treated only by high-tech methods (such as chemical drugs and surgical methods), whereas herbs and lifestyle changes are "unscientific nonsense" and "quackery." Many physicians (perhaps half) believe this propaganda. Some doctors receive various incentives for prescribing drugs or for use of medical equipment. Although these doctors are a minority, they prefer to harm patients by unnecessary treatments for personal gain. Although there are many honest physicians, some of them prefer to treat patients as much as possible, because the more you treat, the farther your career advances. Humans in general tend to lie and try to prove one's importance (or importance of one's profession) for society. For example, most of scientific studies about radiotherapy are written by doctors specializing in this treatment. If you think that these people will honestly tell you that radiotherapy is useless and possibly causes only harm in most cases, then you are gravely mistaken. There are of course honest physicians, but they are a minority, whereas the medical consensus (mainstream view in medicine) is formed by ordinary egotistical humans with conflicts of interest. You need to seek honest physicians who have no illusions about the current healthcare system.

Of course, you can combine conventional and the proposed unconventional treatments if they make sense to you. Consult a healthcare professional about this combination. Among conventional treatments, minor surgical interventions (those that do not require general anesthesia) and targeted therapies are fairly safe and make sense. Unfortunately, most of existing targeted drugs are not very effective against cancer, and there are doubts even about this modest effectiveness [link, link]. Systemic (i.e., cytotoxic) chemotherapy is not only useless but harmful in most cases. Yes, it can shrink a tumor, but chemo also destroys health and kills the patient simultaneously. Quality of life worsens, and survival is not extended (with rare exceptions). My dad had leukemia and was treated with chemo. He did not die of cancer, he died of kidney failure caused by chemo. A major surgical operation is highly dangerous, harmful to your health, and does not address the cause of cancer (the tumor is not the cause of cancer).

Radiotherapy will undoubtedly shrink a tumor but will increase the risk of a new tumor (because of radiation-induced mutations in DNA), whereas the old tumor often comes back more aggressive. Radiotherapy with surgical resection are definitely necessary when a tumor blocks essential physiological functions. It is difficult to say in other situations, especially if we take into account the egotistical mentality and behavior of many physicians as discussed above. Unscrupulous doctors or doctors who blindly believe the modern deeply flawed scientific literature will attempt to convince you that you urgently need to remove or shrink the tumor by conventional treatments. In actuality, the Gonzalez protocol can stop tumor growth and metastases, and you can live with the tumor for many years without a problem (and the tumor will probably gradually shrink). Don't rush into dangerous conventional treatments and think your options through.

Can a big tumor shrink or stay relatively harmless for years without surgical removal? Yes, it can. Do your own research, don’t trust anyone on this topic. Doctors Emanuel Revici, Galina Shatalova, William Donald Kelley, and Nicholas Gonzalez have confirmed this on thousands of cancer patients. Kelley and Gonzalez noticed that if a patient stops consuming the standard unhealthy food and starts consuming large amounts of pancreatic enzymes, then the tumor stops growing and metastasizing in most cases (not always) [link, link, link]. The healthcare industry and those physicians that have been bribed by this industry often employ scare tactics as a marketing ploy. There is also a huge problem of cancer overdiagnosis (cancer diagnosis given to healthy people who will not develop cancer) and cancer overdefinition (definitions of some cancers have been expanded to include as many healthy people as possible) [link, link]. These healthy people are harmed by unnecessary treatment. If you have a real cancer and enhance your immune system, then a large tumor is unlikely to metastasize and will gradually shrink. Haste makes waste. If you want to get rid of cancer overnight, then you may die on the operating table or become a cripple for life, e.g., lose an important organ or body part. You should never hurry with a major operation if you have cancer, especially if you feel well. You need to carefully weigh all the pros and cons. If you feel sick, at least try to achieve a good general state of health and become stronger (as described in this booklet) before you go under the knife if you believe that you must excise your tumor. Judging by the existing scientific evidence, surgical resection cures cancer with high probability in some cases, for example, early-stage colon cancer and early-stage breast cancer. For most of cancer patients, the benefit of surgical methods is less obvious and not as impressive. As with chemotherapy, the small or moderate effectiveness of surgical resection documented in scientific literature is most likely unreal and can be explained by conflicts of interest.

If you are wondering about my credentials on this topic, I have a Ph.D. in molecular and cellular oncology and am an author or coauthor of 16 scientific publications. It should be noted that I have no financial ties to the products and services mentioned in this booklet.

The text below doesn’t contain literary citations because they make it difficult to use the text-to-speech function of various eReader devices. Studies for each chapter are listed in the Literature section.

In conclusion, it is worth mentioning what I mean by the "healthcare industry." These are gigantic corporations producing pharmaceutical drugs and medical equipment. Along with mass media, they are a part of the Matrix. (Readers who don't know what the Matrix is can watch the movie by the same name released in 1999.) Small and medium-size businesses in this field are apparently not a part of the Matrix.

 

Scientifically proven anticancer products (turmeric, vitamin D, black seed, broccoli, and others)

There is plenty of scientific evidence that these products have anticancer effects. Turmeric is supported by the largest amount of scientific evidence, closely followed by vitamin D (link). I am mentioning black seed (Nigella sativa) and ginseng too because these plant products are known to be effective against many diseases, and there is scientific evidence of anticancer properties as well, albeit much less evidence in comparison with turmeric and vitamin D. Turmeric is believed to be a panacea among Hindus, whereas black seed is thought to be a panacea among Muslims. There is a saying that black seed can cure everything but death. Indeed there is evidence that black seed and its major active ingredient (thymoquinone) are effective against many diseases (link, link). You can think of turmeric and black seed as universal metabolism normalizers. Normalization of metabolism is what you need with cancer because currently there is growing evidence that cancer is a metabolic disease. You can do some research on the websites Greenmedinfo.com and PubMed.gov. My advice is to learn how to search PubMed.gov correctly.1)

This scientific evidence is more reliable than the evidence supporting conventional cancer treatments because the researchers who studied these plant products in most cases did not have conflicts of interest. These products are not patented and cannot bring multibillion-dollar profits to corporations. Scientific articles about these anticancer products were not published by ghost writers hired by corporations. The amount of corruption and scientific fraud is not nearly as big as that associated with standard cancer treatments.

You need to study the possible adverse effects of these products and my advice is to use a combination of these products. Even if there is no scientific evidence about your particular type of cancer, you can still take advantage of these beneficial remedies because they are much safer and cheaper than conventional treatments and because anticancer treatments typically are effective against many types of cancer. Note that there are three species of ginseng, American, Siberian, and Korean, and you need to choose the one that has been tested against your type of cancer if possible.

For maximal effectiveness, it is best to consume turmeric twice a day: a level teaspoon of turmeric powder with a small amount of warm soup or salad. On days when you do not consume turmeric, eat a teaspoon of pulverized black seed or black seed oil with a small amount of warm soup or salad in the morning. For example, you can try the following regimen: three days of turmeric and one day of black seed, and repeat this cycle for as long as necessary (you can do this for life if you like). In addition, consume a tablespoon of cod liver (canned is OK) per day; this is the best source vitamin D. Optionally, brief sun-bathing or UV-tanning sessions (1 minute on four sides) can be included too. This is a different source of vitamin D, and moderate sunbathing also serves as hormesis. Take ginseng extract at noon twice a week. Because turmeric, black seed, and ginseng act against blood coagulation, if you get nosebleeds with this regimen, then reduce your dose twofold. Your diet should be diverse and healthy if you want to normalize your metabolism and beat cancer. If your nutrition consists primarily of junk food, then your chances of winning will be much lower.

If and when you recover from cancer, you may choose to reduce your dose of these products twofold or you can continue the same regimen for life. Many studies show that an active ingredient of one of these plants (i.e., a purified chemical) is effective against cancer. My advice is to consume the whole foods (or crude extracts) instead of purified ingredients. For example, eat turmeric powder added to soup instead of popping curcumin pills. Foods are safer than pure chemicals and should be as effective or even more effective. Artificial vitamins and minerals are not assimilated well by the human body and are mostly excreted with urine. Besides, they do not have the same effects on your body as do vitamins and minerals that come with food, i.e., in a “natural package.” For example, consumption of antioxidant-rich foods improves the outcomes of cancer, whereas consumption of artificial antioxidant pills, such as vitamin E, can worsen the outcomes of cancer patients. Remember that lifestyle changes, vitamin-rich foods, herbs, and herbal extracts are the safest therapeutic methods; next we have natural chemicals (which occur in nature such as vitamins and curcumin), which are less safe for your health; and the last place belongs to invented chemicals (do not occur in nature, e.g., most of patented pharmaceutical drugs), which pose the greatest risks for health, as do surgical methods and many other modalities of conventional medicine. A pure chemical may fix one problem in your body but will create 10 other problems, this is also true of artificial vitamins. You need vitamins in their natural packaging: as regular foods. If your goal is to become healthy, then you need to use food as medicine, not drugs as medicine. Nobody will identify a single "active ingredient" that will replace a healthy diet. You need to consume real diverse foods and do many other things as part of your lifestyle to maintain and achieve good health.

In addition, there is a large amount of scientific data on the anticancer properties of pomegranate, broccoli, and green tea. You can see these products and their active ingredients near the top of the list of scientifically proven anticancer products on the Greenmedinfo website (link). For this reason, it will make sense for you to include 50–100 grams (2 to 3 oz.) of raw broccoli into your daily nutrition, preferably passed through a blender. For example, you can make puree from tomatoes and broccoli. I do not recommend soy and soy products (such as soy milk) because they cause a lot of gas, and Dr. Gonzalez has said that soy suppresses the activity of pancreatic enzymes. Given that green tea contains caffeine (actually more than coffee does), drink a cup of green tea at breakfast, not in the evening. Quite possibly, you may have to forgo any stimulants in any form. I consume sedative herbs every day and almost never take stimulants such as ginseng and green tea. I recommend raw (freshly pressed) pomegranate juice for several reasons. The juice will be less taxing on your teeth. There are substantial scientific data showing that pomegranate (link) and its ingredients (vitamin C, vitamin E, and polyphenols, link) are effective against cancer. When I am sick and have no appetite, the only thing I can consume is pomegranate juice or orange juice. If they are freshly pressed, then they make me feel better immediately and improve appetite too. Which leads me to believe that these two raw juices are the healthiest food one can imagine. Avoid or minimize store-bought juices from acidic fruits such as apples, pomegranates, or oranges because they are prepared by means of stainless-steel equipment and therefore contain some heavy metals. There is no convenient way to prepare pomegranate juice without metallic equipment, but you can use a special plastic juicer for citrus fruits at home. You should drink such juices only through a straw to protect your teeth and lips. If you are so sick that you can't eat, then you can consume up to 1.0–1.5 liters (quarts) of raw orange juice per day. Otherwise, drink one glass a day or 1/3 glass pomegranate juice for prophylaxis. In the worst-case scenario, drink pasteurized pomegranate or orange juice. In the town where I live, I can buy freshly pressed pomegranate juice at a local farmer's market year round.

Keep in mind that if you have cancer, only turmeric, natural sources of vitamin D, and broccoli are mandatory among the products described in this chapter because scientific evidence is strong-to-overwhelming. All other products are optional because the amount of evidence is lower.

 

 

1)For example, the search string hepatitis[Title] AND "liver cancer"[Title/Abstract] returns articles where the word hepatitis is mentioned in the title and phrase "liver cancer" occurs in the title or abstract; you can use operators NOT and OR in a similar fashion. You can also use parentheses and construct long search strings with dozens of operators.

 

Moderately cold showers are safe and cannot cause an illness

Many people believe that a cold shower will make them ill; in particular, it “can cause” a cold or the flu. Numerous studies of moderate cooling show that it does not cause respiratory illnesses, yet the notion about the dangers of cooling persists among the populace. This belief is in part correct in that severe cooling, which lowers core body temperature below 35°C (95°F), the state known as hypothermia, can indeed have adverse health effects. Hypothermia can develop as a result of immersion in ice-cold water or administration of certain drugs. In the vast majority of people, cold showers at 20°C (68°F) cannot lower core body temperature below 37°C (98.6°F) and therefore will not have adverse effects on health.

Statisticians know that respiratory infections occur predominantly, though not exclusively, during the cold time of the year. The mechanism underlying this phenomenon is unknown, although two recent studies provide a possible explanation. The first showed that inhalation of cold air by horses during exercise suppresses immunity in the mucous membrane of the respiratory tract. This immunosuppressive effect of cold air can predispose a person to the flu or a cold. The other study showed that cold dry air improves transmission and survival of the influenza virus. Cold air contains much less moisture than warm air does. Transmission and survival of the influenza virus in moist, warm air are much lower. The folk wisdom of keeping a boiling kettle in the house to prevent the spread of influenza among family members should be effective. Therefore, it is possible that the predominant occurrence of flu epidemics during the colder seasons is a result of the above effects.

Cold showers in the atmosphere of room-temperature air will not predispose a person to influenza. My experience and the experience of many other fans of cold water show that cold showers cannot cause respiratory infections. Rare side effects exist, as you will see in a later chapter.

Although moderate cooling is safe, winter swimming is not. Winter swimming is sudden immersion in ice-cold water, and it is a highly stressful and unsafe procedure that you will do well to avoid.

 

The adapted cold shower: an unstressful and easy procedure

I developed a convenient procedure called “adapted cold shower.” This procedure is safe and easy to do, unlike the regular “sudden” cold shower. You can use the method as follows: start with a tepid shower, 34 to 36°C (93 to 97°F), for one to three minutes. Get out of the shower and set the water temperature to about 20°C (68°F). Then get back in the shower and start gradually and slowly expanding the area of contact with the cold water from the feet up. This gradual adaptation phase should take another 2 to 3 minutes. After that, take the whole-body cold shower for 2 to 5 minutes or longer if you feel like it. You can take adapted cold showers two or three times a day when you feel sick. Be sure to place a rubber mat inside your bathtub and another mat beside your bathtub so that you don't slip and fall.

Optionally, you can include a heating procedure before the cold shower once a month or once every two weeks: a hot bath or sauna. I would recommend hot baths instead of a sauna because hot baths will achieve the same heating effect (will raise your core body temperature) without the extreme temperatures of a sauna. If you choose a sauna, then it is best to lie down because heating your legs while you are standing up may lead to varicose veins. Almost a century ago, American physician William Coley successfully treated cancer by inducing a fever (core body temperature of 40°C [104°F] and higher). Hyperthermia is gradually being incorporated into clinical practice as a treatment of cancer and is thought to stimulate innate immunity against cancer cells. My advice is to use moderate hyperthermia (38°C core body temperature that can be achieved in a 40°C bath) as hormesis and an immunostimulant, rather than high hyperthermia designed to kill cancer cells (because there is a risk to kill the patient). The alternative is to raise your core body temperature by intensive exercise. I alternate three types of cardio exercise (stationary bike, rapid lifting of knees while hanging from a horizontal bar, and boxing movements with dumbbells) with short breaks until the body temperature reaches 38°C. I measure the body temperature by means of an electronic thermometer by placing it under the tongue.

 

The many benefits of adapted cold showers for cancer patients

Cold water can do amazing things. For example, a cold shower offers instantaneous relief of pain, nausea, and fatigue. We will review the beneficial effects in the sections that follow.

Reduction of fatigue

Heating the body externally (hot bath, hot environment) is known to cause fatigue. Accordingly, lowering the body temperature to the normal level should reduce fatigue and weakness. But this is not the end of the story. Scientific studies show that even when body temperature is normal, moderate cooling reduces fatigue and acts as a stimulant on the central nervous system. The anti-fatigue effect of whole-body cooling has to do with the reduction of the level of serotonin in the brain.

Some of the first studies of the effects of body cooling on fatigue appeared in the 1960s. One report showed that exposure to cold air can reduce mental fatigue in children when this treatment is combined with physical exercise as well as without exercise. The second study describes the effects of abdominal cold packs and cold showers on physical fatigue in adults, and the authors concluded that these interventions reduce fatigue. More recently, a series of studies that included both healthy subjects and some groups of patients revisited the effects of cooling on fatigue. Some of those recent studies were prompted in part by the observation that in some disorders (e.g., multiple sclerosis), fatigue can increase significantly in a warm environment. This finding led to the development of the cooling suit. Two studies with a small group of multiple sclerosis patients (8 and 10 participants) showed that the cooling suit reduces fatigue both in a warm and in a neutral environment. The authors concluded that this treatment can significantly improve quality of life of multiple sclerosis patients.

Several other studies describe physiological effects of winter swimming, a practice that is rather widespread in Finland. Winter swimming involves immersion in very cold water, 1–10°C (34–50°F), for several minutes. After participants in two initial studies reported reduced tiredness, Dr. Pirkko Huttunen and coworkers (2004, Finland) set out to specifically assess the effects of winter swimming on general well-being, including fatigue. In that study, a mixed group of volunteers, which consisted of healthy subjects and some patients with physical illnesses, used winter swimming four times a week for a total of four months. The results showed that winter swimming caused a significant reduction of fatigue compared to the control group (no treatment). The winter swimming group included patients with fibromyalgia and rheumatoid arthritis, the disorders that are often associated with fatigue. Although this Finnish study did not report adverse effects of winter swimming among the participants, this procedure should be used with extreme caution because it can quickly cause hypothermia and the associated adverse effects on health.

There are several reports showing that body cooling during exercise or between exercise bouts can improve athletic performance.

Reduction of pain

Local application of cooling (for example, to a bruise) is a well-known pain-reducing treatment. Whole-body cooling is a less obvious approach and is more effective because it recruits different biological mechanisms. An increased level of beta-endorphin (a natural painkiller) in blood is one such mechanism. Whole-body cooling also activates other proteins with pain-reducing properties in the spinal cord and in the brain.

An additional mechanism: whole-body cooling provides psychological distraction from pain. Note that adapted cold showers are effective only against mild-to-moderate pain and combining them with pain-relieving drugs such as acetaminophen or ibuprofen is more effective than either treatment alone.

Several clinical trials tested whole-body cooling by means of cold air (cryotherapy) in patients with rheumatoid arthritis, osteoarthritis, and fibromyalgia. These trials have shown that the cooling sessions reduce pain for 1.5–2.0 hours and reduce inflammation (if present) in a more sustained manner. The winter swimming studies, which we discussed above, showed that patients with asthma and rheumatoid arthritis experienced a reduction of pain as a result of immersion in ice-cold water four times a week.

Numerous experiments on laboratory animals in the last three decades showed that a brief cold-water swim causes a substantial reduction of pain. This effect lasts for 5–15 minutes in experiments with acute pain (such as a pin prick). The pain-relieving effect lasts for 1.0–1.5 hours in experiments involving continuous pain.

Enhancement of antitumor immunity

Numerous scientific studies show that whole-body cooling activates the part of the immune system known as “cell-mediated immunity.” This part of the immune system includes special cells called “natural killers” and “cytotoxic T lymphocytes,” which are known to attack tumor cells. This activation of cell-mediated immunity can improve survival of laboratory animals infected with some pathogens, for example, Toxoplasma. The classic experiment by Holloszy and Smith showed that rats cooled for several hours daily (five days a week) develop fewer cancers and live slightly longer. In that study, the repeated cooling almost eliminated sarcomas and reduced the occurrence of carcinomas two-fold, but there was no effect on leukemias and lymphomas. It is possible that the reduced occurrence of sarcomas and carcinomas has to do with the enhancement of cell-mediated immunity. The lack of effect on lymphomas and leukemias (cancers that affect cells of the immune system) may have the same explanation. Repeated cooling enhances proliferation of some cells in the immune system, namely, certain types of T lymphocytes, and this change may cancel out the anticancer benefits of cooling.

Reduction of nausea

Many cancers and cancer treatments cause nausea and a loss of appetite. Whole-body cooling reduces the level of a chemical called serotonin in the brain. This chemical is an important player in the regulation of appetite and nausea. Cooling also increases the blood level of thyroid hormones and adrenocorticotropic hormone, which increase appetite and reduce nausea. My personal experience suggests that moderate cooling has little or no effect on normal appetite, but it does improve bad appetite and reduce nausea, for instance, during an illness such as influenza.

Research shows that both constant and intermittent exposure to cold increase food intake in mammals; this effect is thought to be linked to increased energy expenditure (upregulation of heat production in order to maintain the normal body temperature). For example, food consumption increases in dairy and beef cattle when they live in unheated housing during the cold time of the year. In an experiment by Chen Bing and colleagues (1998), rats spent three weeks in a cold environment (4°C, i.e., 39°F), and this treatment resulted in a 10% increase of food intake. In 2000, J.B. Chambers and coworkers saw similar results in rats after one week of constant cold exposure. Food intake quickly returned to normal after the rats returned to a thermoneutral environment. In another study, Holloszy and Smith kept rats immersed in cold water (23°C, i.e., 73°F) for four hours five days a week, and this regimen resulted in a 44% increase of food intake and increased average metabolic rate (consumption of oxygen).

Somewhat paradoxically, body weight of the cold-exposed animals always declined in the above experiments, despite increased food consumption. For example, Bing and colleagues observed a 14% weight loss in the cold-exposed rats after three weeks. The weight loss is thought to be due to the increased energy expenditure as well as less efficient nutrient assimilation during exposure to cold.

The effects of brief repeated exposure to cold on weight are different. Two studies conducted in the Czech Republic have shown that relatively brief immersion in cold water several times a week for four to six weeks resulted in a slight (statistically insignificant) increase of body fat in human subjects, although these authors did not measure changes in food intake. It is possible that brief repeated exposure to cold causes a slight weight gain because this approach does not significantly increase energy expenditure (for production of heat). At the same time, the brief repeated exposure to cold may produce hormonal changes that are sufficient for stimulation of appetite.

Improvement of mood

Several studies have shown that brief cooling of the body can improve mood in healthy people and in some groups of patients. A study by Berger and Owen conducted in 1983 showed that swimming in a pool improves mood. The temperature of water in a public swimming pool (27–29°C, i.e., 80–86°F) is usually lower than the normal body temperature. It is possible that the moderate cooling effect may in part have been responsible for the improvement of mood in the swimmers, although the authors concluded that physical exercise associated with swimming (50 minutes during each session) is probably responsible for the mood change. A recent clinical trial in Iran showed that swimming in a pool has a weak-to-moderate antidepressant effect.

Another piece of evidence comes from several studies of winter swimmers. Winter swimming does not involve significant amounts of physical exercise but does involve substantial cooling of the body. Immersion in water colder than 16°C (60°F) quickly causes hypothermia (core body temperature of 35°C [95°F] or lower) in human subjects. Two initial studies of winter swimmers were focused on physiological changes caused by this practice; the participants often reported improvement of mood and self-esteem after immersion in cold water. These observations prompted Pirkko Huttunen and colleagues (2004, Finland) to assess the effects of winter swimming on mood. Their study showed that after four months of winter swimming four times a week, self-ratings of mood improved significantly. The participants included healthy subjects and some patients with physical illnesses (asthma, rheumatoid arthritis, osteoarthritis, hypertension, hypothyroidism, Parkinson’s disease, and fibromyalgia) and did not include patients with clinical depression.

Another study (Sweden, 2002) describes the effects of a cooling suit on fatigue and quality of life in multiple sclerosis patients. The authors reported that five out of eight patients experienced “feelings of well-being and happiness” immediately after cooling and the other three participants experienced less irritation caused by fatigue. Another small report showed improvement of mood after cold hydrotherapy (three healthy subjects, who used cold showers and cold affusions on a regular basis; the range of use: 2 to 19 years). A study at the National Institute of Mental Health in 1986 describes the effects of environmental temperature on the symptoms of several patients with summer seasonal depression. The results showed that one female patient, who tested cold showers several times a day during the summer, experienced a dramatic improvement of depressive symptoms after five days of this regimen. Subsequently, when she discontinued cold showers for nine days, this patient experienced a complete relapse of depression.

To date, there have been no statistically significant clinical trials of cold-water treatments as a single therapy for depression. But a recent research article out of Poland showed that combining whole-body cooling (cryotherapy) with medication significantly reduced depressive symptoms in a group of 26 patients with depressive and anxiety disorders (compared to the patients who received only medication). Cryotherapy is brief cooling of the body by means of very cold air (minus 110–160°C, i.e., minus 166–256°F) in a special chamber. A Japanese professor originally developed this method for the treatment of rheumatoid arthritis, and this approach is known to reduce pain and inflammation in this disorder. Dr. Joanna Rymaszewska and coworkers (Poland) observed in the late 1990s that, after several minutes in a cryogenic chamber, in addition to reduced pain, patients often experienced improved mood and euphoria. This observation led this group of investigators to hypothesize that cryotherapy has antidepressant properties. This idea eventually resulted in the above-mentioned study of cryotherapy as a treatment of depression.

In summary, these studies suggest that temporary cooling of the body can improve mood in healthy people, and that addition of this treatment to antidepressant drugs is beneficial for patients with depression. Many of the aforementioned studies showed elevation of normal mood (euphoriant effect), which is not the same as the antidepressant effect or normalization of depressed mood. Although the great majority of antidepressant drugs do not have euphoriant properties, some antidepressants can lift normal mood, for example, tianeptine.

 

Rare side effects

Although cold showers are beneficial during an illness, you should be careful with this procedure if and when you get well. Because of the stimulant effect, an adapted cold shower can cause insomnia if you take it in the evening (when healthy). Adapted cold showers can make you feel great if you take them every day, but, unfortunately, it is possible to be “too healthy.” Adapted cold showers can cause symptoms of hypomania, such as elevated mood, impulsivity, inflated self-esteem, and excessive risk taking. The impulsivity and risk taking are likely to have disastrous consequences for your finances. To decrease activity and to enhance self-control, I recommend raw honey and a mixture of sedative herbs twice a day. Try other sedative measures mentioned in the chapter "55 ways to change your lifestyle..." This way, you will be able to take cold showers on a regular basis, possibly even every day.

In general, adapted cold showers at 20 degrees Celsius (68°F) are safe for the vast majority of people, with rare exceptions such as Raynaud’s syndrome (high sensitivity to cold). Another possible exception (I don’t have documented evidence) is epilepsy, where cold showers may increase the risk of a seizure because this procedure works as a stimulant for the central nervous system. In theory, repeated cooling can be harmful for patients with some leukemias or lymphomas and for patients who undergo an immunosuppression therapy (cooling enhances proliferation and activity of some cells of the immune system, such as T lymphocytes). In addition, water colder than 14°C (56°F) can cause pain in the skin, and swimming in such water can cause hypothermia (lowering of core body temperature).

Adapted cold showers are extremely uncomfortable and impossible to use during chills, even if body temperature is above normal. If you have a cough or laryngitis, cooling of the neck can worsen these problems; therefore, you need to modify this procedure as described below. Take a mixture of raw ginger and hot peppers because they contain fever-reducing and analgesic substances (book "How to Become Smarter," Appendix VII, footnote #23). Also breathe the vapors from this mixture. Drink lemon juice (book "How to Become Smarter," Appendix VII, footnote #20) because it also reduces inflammation and invigorates (reduces general weakness). If you have a cough and a fever and you are dying to try a cold shower, you can modify the adapted cold shower procedure to prevent cooling the neck. The modified cold shower procedure does not worsen coughing and laryngitis, but it is more complicated. Wrap a scarf around your neck. You skip the preliminary tepid shower, and when you start the gradual adaptation phase, you stop expanding the area of contact with cold water when you reach the neck. You can apply the cold shower to the shoulders, avoiding splashing water on the neck. You will cool the head afterwards using a separate procedure, the “head shower.”

You can use the cold shower for the head (the head shower) as follows. Keep the scarf on. Insert earplugs, set water temperature to about 20°C (68°F), kneel by the tub or shower stall, and tilt your head forward so that it is in the horizontal position, face down. You can now apply the cold shower to the head, but avoid wetting the neck. Adjust the flow of water to a comfortable level. If you do not use the earplugs, the water will enter the ear canal: an uncomfortable effect. After you dry yourself off, wrap a new dry scarf around your neck and keep in on for 30–60 minutes after the shower. To prevent your body temperature from creeping up, remove as many other clothes as possible. The scarf is optional if you do not have a cough or laryngitis.

The modified cold shower procedure has beneficial effects similar to those of the adapted cold shower, without worsening a cough. Keep in mind that cold food and drinks as well as going outdoors in cold weather will worsen coughing.

Heating of the body affects the regulation of blood pressure and people with low blood pressure should be careful because there is a risk of fainting. As a rule of thumb, abort a sauna or hot bath if you experience dizziness, changes of vision, malaise, nausea, or other unusual symptoms. Hot showers can trigger seizures in some patients with epilepsy and headache in patients with migraine or other headache disorders. Both local and whole-body heating can worsen inflammatory conditions. Heat can cause severe fatigue in patients with multiple sclerosis. It can also have an adverse interaction with some medications. The medications or substances in question are alcohol, alpha-andrenergics, amphetamines, anticholinergics, antihistamines, benzodiazepines, beta-blockers, calcium channel blockers, cocaine, diuretics, laxatives, neuroleptics, phenothiazines, thyroid agonists, and tricyclic antidepressants. The above list of possible problems is by no means complete. Unless you are a healthy person who is not taking any medication, you need to consult your doctor before using hot hydrotherapy or a hot environment in your home.

Brief cardio exercise

WARNING: Intensive physical exercises are not safe during some cardiovascular diseases, especially among the elderly. It's a good idea to have a defibrillator nearby and to not exercise without supervision. Consult a healthcare professional.

There are many clinical trials showing benefits of physical exercise for cancer patients. If you do some research on PubMed.gov, you will see that physical exercise affects the numbers and activities of the immune cells that are primarily responsible for fighting cancer: T lymphocytes and natural killer cells. Therefore, an intensive program of physical exercise should help to wake up your immune system and to normalize your metabolism. There is a lot of scientific evidence showing that cancer is associated with (and likely caused by) aberrations in metabolism. The problem with physical exercise is that it requires a bit of time and will power, and these two obstacles prevent most people from exercising regularly. I devised a regimen called brief cardio exercise, which takes only 15 seconds once a day. Intensive physical exercise may be harmful for people with some health problems, and in my opinion, brief cardio exercise should be avoided during a manic or hypomanic episode. For the elderly and people with cardiovascular diseases, it's a good idea to have a defibrillator nearby and to not exercise without supervision. People for whom cardio exercise poses a risk should start very carefully, with 2 seconds of mild cardio, and gradually increase the duration and intensity over 1 month. Excessive amounts of exercise (30–60 min daily or 6 days a week with sweating) induce fatigue and have a sedative effect. Ideally, your physical exercise regimen should take up little time and require as little will power as possible. The reason is that self-control is a limited resource; if you spend most of it on forcing yourself to exercise, then you have little left to maintain a healthy diet. In my view, the type of exercise that requires the least time and effort is a stationary bicycle in your home. I recommend the following regimen: The laziest approach is 15 seconds of maximal-speed cycling once a day, 6 days a week. One day per week you do not exercise. Your pulse must accelerate at least twofold during each session. This lazy version of cardio exercise should be an exception rather than a rule in your lifestyle because there is a risk that you will pull a muscle or damage your knee joint (a torn ligament is no fun). A less lazy version is cycling for 10 minutes at normal speed (insert two 1-minute breaks), followed by 15 seconds of maximal-speed cycling. The next day, you do several minutes of some other cardio exercise, for example, sit-ups (or lifting your legs while you are hanging from a horizontal bar), and the day after that, several minutes of cardio exercise with your arms. For this purpose, you need two dumbbells, not too heavy, with which you can do cycling or boxing movements using your arms while standing up. (Brief stretching for your arms is recommended before this exercise.) The cardio exercise with dumbbells requires caution: first do two mild sessions (with a 2-3-minute break) at moderate speed as long as you can hold up your arms; during the third session, use high speed but not the maximal speed. If you start with the max speed, then you may develop tension headache or backache. You will notice that your pulse and breathing accelerate almost as much as they do when you cycle with your legs, except your legs and knee joints are getting some rest. You need to take good care of your knee joints and give them plenty of time to recover from this strenuous activity. Alternate these three types of cardio exercise. To minimize intracranial pressure, instead of sit-ups, lift your knees rapidly while hanging from a horizontal bar (three sets of 30 repeats with a 1- to 2-minute break). Avoid the types of exercise that strongly increase intracranial pressure, for example, pushups, because they can damage blood vessels in your head.

Obviously, physical exercise is forbidden after a surgical procedure; you will have to wait until your surgical wounds heal properly. If you had a hemorrhagic stroke recently or are at a risk of hemorrhage, strenuous exercise is not for you either. There may be other contraindications; talk to a healthcare professional. There are many clinical trials showing benefits of physical exercise for cancer patients, but evidence about your specific type of cancer may be still unavailable. Given the dismal state of science and biomedical research at present (as explained in my other book “How to Become Smarter,” Chapter One, section “Interpreting evidence from studies on human subjects”), you cannot wait for scientists to prove or disprove the effectiveness of exercise against your type of cancer. Even if exercise is rigorously proven to be effective against cancer, this regimen will not show up in clinical practice guidelines without expensive lobbying. This means that if a treatment is effective and safe, but brings no profit to anyone, this treatment may never appear in clinical practice guidelines. We live in a profoundly perverted and corrupt world. Undoubtedly, you can still add the proposed (or some other) regimen of exercise to your cancer treatment plan. You will get the following benefits: less fatigue, better mood, normalization of appetite, normalization of metabolism, and a possible immunostimulatory (antitumor) effect.

If your state of health does not allow you to exercise every day, then try exercising every other day. In any case, if and when you recover from cancer, you can reduce the frequency of cardio exercise by half. William Donald Kelley has said that cancer patients who've lost substantial amounts of muscle mass should avoid intensive exercise because it can cause a hernia. Instead he recommended brisk walking.

Benefits of ultraviolet light

According to the literature research conducted by greenmedinfo.com, exposure to sunlight is the unconventional procedure most strongly supported by scientific evidence as an anticancer modality. Formation of vitamin D may be one of the mechanisms, but hormesis may be another, and we still do not know everything about what happens in the human body during exposure to sun light.

If sun rays are unavailable, you can use a tanning bed or vertical home solarium instead, which is not exactly the same, but pretty close. To minimize the risk of skin cancer (which in my opinion is exaggerated or made up in mass media), choose a dose that causes little or no tan. Don’t forget to put on special goggles to protect your eyes. Don’t look at the UV lamps directly even through the goggles. You will also need a floor fan placed about 1–2 meters away to blow off ozone, which is produced by UV light when it interacts with oxygen in the air. Start with a 1-minute session in a tanning bed or tanning booth per week, and then gradually increase the frequency of 1-minute sessions to once a day (or twice a day with a 12-hour interval) 6 days a week. If you are healthy, then one short session per day will suffice, but if you are sick, then do two sessions a day. On sunny days, instead of the solarium, open a window and tan while one of four parts of your body is exposed to sunlight (~1 minute each): front torso and face, the back and the back side of the head, front side of legs, and back side of legs. Do not allow heating of the skin. Do the whole cycle 6-10 times. The whole procedure should take 30-60 minutes. With a little practice, you will be able to catch the sun even on cloudy days. You can also relax mentally and meditate during these 30 to 60 minutes of sunbathing. Don't be afraid of the cold, you can do the same in the winter. Never mind the tone of your skin, your goal is to imbibe solar energy.

To minimize the risk of sunburn, follow these principles: 1) smaller intensity of lamps with longer duration of tanning sessions and 2) a lower dose per session with greater frequency of sessions. If you have a home solarium with total power of lamps of 1000 watts, then pull out half of the lamps and set them aside for future replacements (or install lamps with half the power). Now, with half the power of your solarium, you can conduct 2-minute sessions (8 minutes total on four sides) instead of 1-minute sections at full power.

The expected benefits of hormesis are as follows: Small doses of UV irradiation cause small amounts of DNA damage in the skin, which is easily repaired and serves as an exercise for your body, simultaneously improving other defensive mechanisms. Avoid sunblock because it is bad for your skin and for your health; to avoid sunburn, stay in the shade or cover your skin with clothes.

Regarding the formation of vitamin D, according to my self-experimentation, a vertical solarium (a home machine called Plaza XL from JW Sales GmbH, Germany; 10 UV lamps, 176 cm long, 3.6% UVB, 100 watts each) at 2 minutes a day on each of the four sides of my body (front, back, left side, right side), total 8 minutes a day, 6 days a week raises the blood level of vitamin D to the normal range after 3 weeks of this regimen, without any dietary supplementation with vitamin D. The tan will become noticeable only after 3 or 4 months of this regimen.

As mentioned above, I recommend daily small amounts of cod liver and/or fish oil, which is another natural source of vitamin D. You should know of course that vitamins that come from natural sources have different effects on your body and are assimilated differently by your system as compared to artificial vitamin supplements. Artificial vitamins are poorly assimilated and are mostly excreted with urine.

If you will be “sunbathing” daily by means of a home vertical solarium (on all four sides of your body sequentially), then the front top of your feet will receive a larger dose of UV irradiation, and you may notice some freckles there. To prevent this problem, you can wear slippers during these sessions. Examine your skin every now and then. If you notice something unusual, for example, a red spot that cannot be explained, then stop the UV sessions for a week or two until these changes disappear.

Various raw diets for losing overweight and tumors

The rationale for a raw diet is that it is the ancestral diet of humans and the natural diet of animals living in the wild. Thermal cooking destroys many vitamins, enzymes, and other beneficial substances in food. Addition of various artificial chemicals to human food cannot be beneficial for health either. Therefore, a raw diet free of any additives and typical seasonings should improve health and possibly cure cancer. Dentist Weston Price studied the influence of nutrition on dental caries across the globe and found that primitive cultures living on simple natural foods (in some cases, mostly raw food) are vitually unaffected by cancer. The prevalence of tooth decay in some cultures is zero, and in most of such primitive communities is approximately 30-fold lower than that in civilized populations. Members of these primitive cultures or tribes who start consuming civilized highly processed foods experience rampant caries and come down with the same diseases that are prevalent in civilized communities, including cancer, according to Weston Price.

The other benefit is that a raw diet will help to lose excess body weight and even to reach the lower limit of the norm. Your body will get rid of all unnecessary stuff including your tumor and metastases. The question is what kind of raw diet should you choose? I propose testing two types of raw diet: a vegan (plant-based) raw diet and a raw diet including socially acceptable raw animal foods (hereafter: raw omnivorous diet). The raw vegan diet is rather difficult (but not impossible) and is incompatible with some types of work; the raw omnivorous diet is easier to comply with and is compatible with any type of work, including hard mental labor. Even if you believe (as I do) that humans are not vegetarians by nature, you can still go on a raw vegan diet for a few weeks or months for therapeutic purposes. Keep an open mind. The proposed diets contain plenty of calories, but most people lose weight on raw diets, slowly but surely, probably because of rejuvenation. Cancer patients who are underweight are likely to gain weight as reported by some patients, probably because of normalization of metabolism.

Raw vegan diet. Eat raw fruits and vegetables, raw juices, raw vegetable puree (prepared in a blender), diluted raw honey (this is actually an animal product), seeds, and nuts. Avoid potatoes, legumes, and cereal grains. Some grains are edible raw but may cause a lot of flatulence. If you eat sprouted grains, then this problem is less pronounced. Some people cannot tolerate raw fruits and vegetables, for instance, these foods are contraindicated in some diseases of the pancreas. In such cases, Dr. Galina Shatalova recommended to eat sprouted grains or soaked and slightly boiled (1 minute) cereal grains. I would say that if you cannot tolerate fruits and vegetables, then you can try raw milk in small amounts daily (or see the other raw diet below). Nuts and seeds need to be pulverized in a blender or meat-grinder, and they are heavy foods for most people. You will be able to eat only small amounts of nuts and seeds while on the raw vegan diet; otherwise, you will feel bad. I recommend making vegetable puree instead of juices, first, because it is faster to make a puree in a blender, and second, because it requires less raw material. Because this diet increases activity and reduces self-control, I recommend raw honey and a mixture of sedative herbs twice a day (pulverize dry herbs in a powerful blender and mix raw with water). Try other sedative measures mentioned in the chapter "55 ways to change your lifestyle..." Usually, you will feel younger and lighter on this diet, but some people do not tolerate well an abrupt switch to this diet. If you have time, consider a transition period of 2 weeks, where you gradually increase the proportion of raw food in your diet. Complete colon cleansing will facilitate the transition too (see point #8 and its footnote in the appendix "55 ways to change your lifestyle..." in my book "How to Become Smarter"). If you live with people who consume a standard diet including junk food, then staying on the raw vegan diet for a long period will be very difficult. There is a high risk of binging on cooked food and junk food, and you feel bad after such episodes both physically and mentally. You can try staying on a raw vegan diet for 1 day a week and then eating healthy cooked and raw foods the rest of the time. If you live alone or with someone who stays on a similar diet, then compliance with the raw vegan diet will be much easier, and binging will be rare. I recommend renting a separate apartment for a month or two, where you will be able to easily follow any diet and will improve your health sufficiently. In any case, I recommend that you prepare for binging episodes by having healthy cooked food available or perhaps by planning cooked meals once a month, to prevent unplanned binging. The following raw and cooked foods (free of any additives and seasonings) will not increase body weight and will not damage your health if you eat them to satiety from time to time while staying on the raw vegan diet most of the time: raw eggs (washed with soap), boiled eggs, raw mutton fat (tail fat; passed through a meat-grinder), raw scallops, small amounts of mild-cured fish (no more than 10 g/day), boiled beef liver, fish oil (no more than 2 teaspoons a day), canned cod liver (no more than 10 g/day), soup made of low-starch vegetables and mushrooms (avoid legumes), raw dairy (small amounts once every 1-2 weeks), and boiled whole chicken (bought frozen in a grocery store; including broth, fat, skin, and some organs; crack the bones with a nut-cracker and eat bone marrow; cut off the soft ends of bones and cartilage and pulverize them in a blender with a small amount of the broth). The raw animal foods will be discussed in more detail below. I guarantee that you will still feel great and will keep losing excess body weight after binging on these healthy and tasty foods. Avoid lean types of chicken. Here is why I think the raw vegan diet is not a natural diet for humans: there are no known cultures or ethnic groups that live on a vegan diet, i.e. do not consume some type of animal foods (according to Weston Price's research). Most of people over 100 years old are not vegans. Our closest genetic relatives, chimps, eat raw meat in the wild. Human digestive tract has a structure intermediate between carnivores and vegetarian animals. The raw vegan diet can cure many diseases and is useful as a therapeutic method. The Russian physician Galina S. Shatalova has cured hundreds of people (perhaps tens of thousands through her books) of cancer, cardiovascular diseases, and diabetes by means of a mostly raw vegan diet, breathing exercises, contrast hydrotherapy, and other lifestyle changes included in her method. Unfortunately, the raw vegan diet is not suitable for everyday life for most people. People have different types of metabolism and job requirements. If this type of diet is suitable for your lifestyle and profession, then I am glad for you. I believe that the vegan diet is not suitable for many types of mental tasks; for example, you will not be able to read and write scientific articles while living on a vegan diet, at least I can't. I believe that you will obtain similar benefits for health if you live on a socially acceptable raw omnivorous diet, which does not compromise work capacity in any way.

Raw omnivorous diet. In addition to the foods mentioned in the raw vegan diet, you can eat raw eggs (washed with soap) up to 10 per day, raw mutton fat (tail fat; passed through a meat-grinder), fish oil (no more than 2 teaspoons a day; it is manufactured at 50°C), raw scallops, small amounts of mild-cured (i.e., slightly salted, not smoked) ocean or sea fish (no more than 10 g/day), raw dairy (small amounts once every 1-2 weeks), and some exotic seafoods that are OK to eat raw in a cultured society (oyster, surf clam, arkshell, and sea urchin). Avoid raw mussels, because the taste is awful and not everyone tolerates them well; I throw up after I eat them. For safety, you should buy tail fat only from kosher or halal vendors (minimal risk of pork parasites). Wash it thoroughly under cold water, cut off all meat and bones, and then pass the fat through a meat-grinder and freeze in ~0.5 kg pieces. All the above foods are socially acceptable or perhaps a little strange and will not make you an outcast. In any case, you can say that you have cancer and need a therapeutic diet. Avoid store-bought or restaurant sushi because it typically contains lots of bad ingredients. While on the raw omnivorous diet, you will be able to consume larger amounts of nuts and seeds, which will give you additional protein. The same principles apply to the raw omnivorous diet regarding gradual transition and sedative measures as described above for the raw vegan diet. Don't worry about cholesterol in eggs and tail fat. U.S. healthcare authorities recently stopped recommending limiting your dietary cholesterol intake, because dietary cholesterol has no effect on blood cholesterol (the latter is synthesized in the liver). The notion that dietary cholesterol causes cardiovascular diseases is another example of a false theory that has dominated medicine for many decades. I should say that in a tiny percentage of population, dietary cholesterol does affect the blood cholesterol level, but this should not be cause for concern because there are many myths about blood cholesterol too. Search PubMed.gov for "Ravnskov U" (without quotes) to find scientific articles dealing with myths about fat and cholesterol. The dangers of raw animal foods are greatly exaggerated by conventional medicine. The risk of pathogenic bacteria exists, same as in raw fruits and vegetables. Should you stop eating raw fruits and vegetables? No. The Japanese eat raw oceanic fish and other raw seafoods almost daily and are among the longest-lived people. According to conventional medicine, the Japanese should die at a young age from pathogenic bacteria in raw fish. Yakuts eat raw meat and fish and can live to be 100 years old. Some species of crocodiles live well over 100 years; why don't they die from pathogenic bacteria and viruses in raw meat and fish? Conventional medicine has also given us other pearls of wisdom: "dietary fat causes obesity," "sunbathing causes skin cancer," "sunblock is good for health," "raw milk is bad for health," "lobotomy is beneficial for mental health," "psychiatric drugs are good for the brain," etc., etc. Many modern physicians are well brainwashed regarding raw animal foods; therefore, it makes little sense asking a doctor whether it is safe for you to eat raw eggs or raw mutton fat. Do your own research. I will describe below how to treat an infectious disease that may result from raw food. The raw omnivorous diet is relatively easy to adhere to and will give you excellent capacity for any kind of work, but there is still a low risk of binging on junk food if you live with people who eat a standard diet. I recommend renting a separate apartment for a month or two, where you will be able to easily follow any diet and will improve your health sufficiently. Keep the following foods (free of any additives and typical seasonings) quickly available to prevent binging on bad food: boiled eggs, boiled beef liver, canned cod liver (no more than 10 g/day), soup made of low-starch vegetables and mushrooms (avoid legumes), and boiled whole chicken bought frozen in a grocery store (eat the broth, fat, skin, and some organs; crack the bones with a nut-cracker and eat bone marrow; cut off the soft ends of bones and cartilage and pulverize them in a blender with a small amount of the broth). Keep the ingredients ready so that you can prepare these foods quickly. These healthy cooked foods will help you to lose excess weight and will not interfere with your recovery from cancer.

A raw diet may increase the amount of gas in the digestive tract. To solve this problem, see appendix VII (endnote 8) in my book "How to Become Smarter."

The above raw foods are safe, but if a food-born illness does happen, in my personal experience, the following treatments are effective, making all symptoms disappear within a day or two. Adapted cold showers at 20°C (68°F), 2 or 3 times a day, eliminate fever, reduce pain (headache, stomach ache or muscle ache), and reduce fatigue, nausea, and general weakness. There is some scientific evidence that this procedure also stimulates the immune system. Take a mixture of raw ginger and hot peppers because they contain fever-reducing and analgesic substances (book "How to Become Smarter," Appendix VII, footnote #23). Drink lemon juice (book "How to Become Smarter," Appendix VII, footnote #20) because it also reduces inflammation and invigorates (reduces general weakness). In the case of diarrhea, enemas are effective (book "How to Become Smarter," Appendix VII, footnote #8). You can use warm tap water or warm saline for colon cleansing; the total of 4 to 5 liters of intermittent inflow/outflow per session are usually enough. Oral antibiotics (antidiarrheal) are not recommended. Incidentally, there are antibiotic foods [raw garlic and undiluted raw honey] and herbs, which may be considered.

If you live alone, then you are not bound by rules of propriety and can try eating raw meat and fish, in addition to the above-mentioned raw animal foods. I do not recommend this approach because a raw diet that includes meat and fish, in substantial amounts, may cause hypomania and problems with anger and with self-control, according to my experience. Nonetheless, people have different types of metabolism, and this kind of diet may be OK for someone. If you are still interested then read on; otherwise, skip to the next chapter.

The current state of science and technology allows us to make raw meat safe for human consumption. Namely, it is now possible to kill virtually all parasites and bacteria in meat without introducing chemical changes into meat, such as those caused by thermal cooking. This kind of safe raw meat has many health benefits and advantages over cooked meat (the new methods of sterilization will be described below). In contrast to cooked meat, raw meat does not promote constipation, does not lower mood, does not increase fatigue, and does not overload kidneys. Both cooked and raw meat increase the level of hemoglobin in blood (i.e., help to rebuild red blood cells), but safe raw meat does not have the above-mentioned adverse effects. Most importantly, raw meat does not contain carcinogens, which are known to form in cooked meat. These carcinogens (approximately 17 known heterocyclic amines) form when meat is heated, and the amount produced depends on the temperature and duration of cooking. Even boiled and steamed meat contain carcinogens but much less than meat cooked at high temperatures, e.g., fried or barbecued meat.

In 2012, the FDA approved pascalization as a method of pasteurization of food products. Pascalized foods are widely available in Japan and Spain and now can be found in the United States too. The FDA has not stated publicly that pascalized raw meat is safe for human consumption, but scientific studies show that pascalized meat is as safe as boiled meat (both boiling and pascalization kill parasites and active bacteria but fail to kill the spores of some bacteria and some viruses). I invented my own sterilization method, which may be cheaper and more effective than pascalization: repeated freezing and thawing with simultaneous ultrasonication. For more details on new sterilization technologies, see endnote B in my book “How to Become Smarter.”

Besides, you can try a regimen of gradual vaccination. Choose a source of raw meat that you consider the safest, for example, a supermarket where workers strictly follow sanitation rules. Start consuming micro amounts of raw ground meat (beef, turkey, or chicken, select only one type of meat for "vaccination"): on the first day, eat a piece the size of a water drop. Then wait one week. If nothing happened, then double the dose of raw meat and wait another week. Thus, continue doubling the amount of meat once a week. If you get sick from pathogens in the raw meat (diarrhea, fever, nausea), then treat this illness as described above or get medical help. As a result of this vaccination, you will be able to safely consume one type of raw ground meat from one brand of supermarkets. To eat a different type of ground meat from the same or different supermarket, you need to start the whole procedure from scratch. Because there is a very small risk of infection with pork tapeworm (if the meat you bought in the store was in contact with a meat-grinder that was used to mince contaminated pork), my advice is to always wash your hands thoroughly with soap after going number two. It is also advisable to buy raw meat from a halal or kosher seller. Only in this case, can you be sure that the raw meat has not been in contact with equipment containing raw pork. Ingestion of pork tapeworm cysts with meat may cause intestinal attachment of the tapeworm and shedding of larvae with stool. If you don't wash your hands, then ingestion of these larvae can have serious consequences because larvae enter the bloodstream and can settle in muscles and in the brain. Unfortunately, pork tapeworm larvae may already be present in contaminated pork if it comes from a low-quality farm. Either thermal cooking or pascalization will kill both cysts and larvae of the pork tapeworm. Freezing and thawing the meat two times (two cycles) will do the same. Even one-time freezing at minus 20 degrees Celsius for four days will kill this parasite.

Note that I am not saying that you should avoid all cooked meat and eat only raw meat. In my view, boiled or steamed meat does not pose a cancer risk because the level of carcinogens is too low. In fact, I believe that humans have adapted to cooked meat (and other cooked food) during the last 350 thousand years (use of fire for cooking) and must cook at least 30–50% of meat in the diet for normal functioning. Self-experimentation suggests that a 100% raw diet can be fun on a short-term basis, but if you are healthy, after several weeks, this diet is likely to cause symptoms of hypomania: hyperactivity, low need for sleep, low self-control, constantly elevated or angry mood, and excessive risk taking. You are likely to crash after you suffer the painful consequences of this behavior. You can prolong the raw diet without hypomania if you take the following measures: take a mixture of sedative herbs twice a day, replace all meat and fish with raw tail fat and raw eggs, eat enough raw honey daily (instead of fruits), increase air temperature, and do breath-holding exercises (three repeats once or twice daily). You must temporarily stop all stimulant procedures: don't drink tea and coffee and avoid other stimulant herbs, brief cardio exercise, hyperventilation exercise, cold showers, and sun-bathing.

Specifically for cancer patients, safe raw meat has the following benefits: a) faster recovery after (or between) cancer treatments; b) raw meat will help you to regain healthy weight and to rebuild red blood cells and immune cells; c) because of this antianemia effect, raw meat is also likely to reduce cancer-related fatigue; d) scientific studies show that raw meat does not lower mood (in contrast to cooked meat), but I would go further and state that raw meat improves both depressed and normal mood, according to my personal experience and scientific rationale presented in my other book, “How to Become Smarter.” For these reasons, consumption of safe raw meat can allow a cancer patient to undertake more cancer treatments and will thus increase the chances of survival.

Uncooked meat has some drawbacks too: for example, because of the long-standing ban by medical authorities, consumption of raw meat is not socially acceptable in most countries. Given that raw meat can be made safe at present, this food may become socially acceptable in the near future. In addition, raw meat is too tough and difficult to chew. For this reason, I recommend passing it through a meat grinder. You can add raw ground meat to a salad or make a sandwich with vegetables and whole-grain bread. In contrast to cooked meat, raw ground meat is an easy food: you can scarf down a pound (~0.5 kg) in one sitting and feel hungry an hour later. For therapeutic purposes, I would recommend 0.5–1.0 kg of raw ground meat per day. Better yet, you can try a 100% raw diet, consisting of safe raw meat and vegetables (plus a small amount of fruit). You can stay on this diet for several weeks. Then add some boiled foods to your diet and try the raw diet again, until you recover from cancer. The raw diet will normalize your metabolism and thereby help to fight cancer. You will also feel younger and less fatigued. An argument can be made that the raw diet is a human ancestral diet because humans used this type of nutrition 200 to 300 thousand years ago before the mastery of fire for cooking.

I am not the first person to propose a raw diet as a treatment of cancer. One can sum up this approach as the “cooked diet theory of disease.” Guy-Claude Burger was one of the first people who proposed this theory, in the 1960s (his theory did not have that title; the title was “instinctive eating”). Burger’s theory did not single out cancer but encompassed almost all human diseases. The logical implication of this theory was that a return to the ancestral diet, that is, the diet that consists of raw foods such as fish, meat, fruits, vegetables, and nuts and excludes everything else, should produce a clinical improvement or a cure in almost any disease. Max Gerson proposed a mostly raw vegan diet to combat cancer, as did Bill Henderson (mostly raw vegetarian diet), and developers of the Rave diet (a vegan diet). Aajonus Vonderplanitz is a recent proponent of a raw-meat-based diet as a treatment of cancer. All above-mentioned people claimed to have documented evidence of effectiveness of raw or almost raw diets against cancer. Most of this evidence has not been published in peer-reviewed journals (search for "Gerson[Title] AND cancer[Title]" without quotes on PubMed.gov). In my opinion, Nicholas Gonzalez and William Donald Kelley have provided the best documented evidence for the effectiveness of a raw diet and other diets against cancer. We will discuss this topic in a separate chapter later.

If you cannot stay on a raw diet for some reason, then you can try eating a raw diet one day a weak and then stay on a balanced healthy diet that is supplemented with all vitamins and other micronutrients from natural sources, not from artificial chemicals: 10 grams of canned cod liver (every 1-2 days; vitamin D), 10 grams of beef liver or pork liver, canned or boiled (every 1-2 days, vitamin B12), small amounts of seaweeds daily (iodine and many other rare elements), half a cup of multivegetable juice daily (various vitamins), half a cup of multifruit juice daily (various vitamins), and a teaspoon of raw honey 1-2 times a week (can be gradually increased up to several tablespoons a day). Note that high-fat meat (>50%) is much better tolerated than lean meat (which I consider a poison) and barely has such adverse effects as low mood and fatigue. Add beef or mutton fat (not fried fat) to your meat. If you want to eat boiled meat in unlimited amounts, then you need to consume fiber supplements such as psyllium husks or Cyamopsis tetragonoloba to prevent constipation.

The importance of organ meats: the pancreas, liver, and thymus

I have read several dozen books about alternative cancer treatments, half of them rapidly by glancing through pages. Grateful former cancer patients mention two methods most frequently. These two cancer therapies well-tested by the common folk—the Gerson therapy (devised by Max Gerson, M.D.) and the Gonzalez protocol (developed by Nicholas J. Gonzalez, M.D.)—include raw animal organs or formulations prepared from raw organs. The Gerson therapy includes an extract from the raw veal liver, whereas the Gonzalez protocol is based on enzymes from the raw pig pancreas. If these enzymes are heated, then they completely lose their activity, for an obvious reason: heating denatures the enzymes. Doctor Gonzalez has noticed that if these enzymes are thoroughly purified, then they also substantially lose their effectiveness against cancer. Therefore, it is possible that the pancreatic product that he recommends (i.e., an unpurified freeze-dried homogenate of the raw pig pancreas) contains some other substances that have anticancer properties. It should be noted that scientists who have nothing to do with cancer treatment have proven that pancreatic enzyme are not destroyed in the digestive tract of humans and get into the blood stream in one piece. (Most of other proteins that are consumed by a person are degraded during digestion by the very pancreatic enzymes, one's own.) Doctor Gonzalez recommends only pig enzymes because the physiology of pigs (omnivorous animals) is pretty close to the physiology of humans (also omnivores). Doctor Gonzalez does not recommend pancreatic enzymes of plant-eating animals such as cows and sheep.

In my opinion, the scientific hypothesis that can explain the anticancer properties of pancreatic enzymes of the liver extract is that primates in the wild and human evolutionary ancestors consume/consumed raw meat and organs, and the latter contain certain substances such as enzymes that are necessary for the best health. Modern humans do not eat raw organs (with some exceptions, such as ethnic groups living in the Arctic region) and therefore they come down with cancer if some genetic predisposition is present. Another scientific explanation of the Gonzalez protocol, his own, is given in a separate chapter at the end of this book.

One can buy lyophilized formulations of the pig pancreas and of the beef liver in the form of capsules. Doctor Gonzalez collaborated with a company called Nutricology. For cancer treatment, he recommended 100-200 capsules per day depending on the person's weight. Alternatively, you can make arrangements with workers of a slaughterhouse or at a farmer's market, so that they sell you pig pancreases periodically. It won't be easy to find such people, and you may have to offer them a high price and to purchase a large batch. My advice is to freeze and thaw the pig pancreas completely two or three times (not in a microwave oven), in order to kill the larvae and cysts of the pork tapeworm: this is a dangerous parasite that can take up residence in the brain by traveling through the blood stream. Thus, after three freeze-thaw cycles, enzymatic activity will be lost partially but not completely. It has been scientifically proven that pork tapeworm cysts will die if meat is frozen even once below –20°C and is kept at this temperature for four days. To be sure, you can repeat this procedure twice. By my estimates, there should be 30-50% of active enzymes after this procedure (incidentally, lyophilization also reduces enzymatic activity). Now pass the pancreas through a meat-grinder and freeze it. If you have cancer, then consume 100-200 grams per day divided into two doses, and if you are healthy, then you can eat 30-100 grams of the pancreas per day for prophylaxis. Doctor Gonzalez recommended taking the pancreatic product 4 hours after and 1 hour before a meal. If you get a bacterial infection (freezing-thawing kills bacteria but not very effectively, you need 30-40 cycles), then you can cure yourself easily (see the previous section). Besides, American surgeon William Coley has proven that a bacterial infection with a fever often cures cancer because of immunostimulation. This is where the hyperthermia-based treatment of cancer came from and is used to this day in clinical practice. If you have cancer, then temporary diarrhea and a fever will be the least of your problems. For comparison, you may die or become a cripple after a surgical operation or a course of chemotherapy. In any case, the risk of infectious disease will be negligible if you decide to consume capsules instead of raw organs.

The raw beef liver (or veal liver) does not require such precautionary measures. You can simply put it in a freezer and thaw small pieces and eat them in this form. In my experience, a raw liver tastes like chocolate. You don't have to pass it through a meat-grinder because it is easy to chew, but you have to cut out large bile ducts and ligaments because they are difficult to chew. If the liver contains these structures, then you need to either pulverize it in a blender with a small amount of water or pass it through a meat-grinder. The alternative is to buy lyophilized beef liver in the form of capsules.

In the worst case, if you cannot buy the capsules and the raw pig pancreas, you may try pancreatin (can have various brand names), which is available in any pharmacy. These are enzymes purified from the pig pancreas (lipases, proteases, and amylases). According to the experience of Nicholas Gonzalez and William Kelley, purified pancreatic enzymes are less effective against cancer.

The raw or cooked thymus (e.g., beef or chicken thymus) will also be beneficial. There is plenty of scientific data about anticancer properties of some formulations (peptides) prepared from the thymus. Probably, they positively affect the immune system because the thymus is an immune organ. Doctor Gonzalez and his predecessor, doctor William Kelley, both prescribed capsules of the raw liver and raw thymus in small doses, aside from the pancreatic product, which was prescribed in large doses.

55 ways to change your lifestyle for health improvement

Finally, you need a healthy lifestyle that will help to combat cancer and prevent its recurrence. Conventional cancer treatments do not address the cause of cancer, which is a metabolic aberration and immune-system failure resulting from a suboptimal lifestyle and genetic predisposition. There is documented evidence that a comprehensive lifestyle change can cure cancer even at an advanced (hopeless) stage. I recommend the books and scientific articles by Nicholas Gonzalez and the book “Radical Remission” by Kelly Turner.

The list of lifestyle interventions below is quite different from what the majority of people believe to be a healthy lifestyle. Chances are you have never heard of some items on the list; they are based on hormesis. The proposed methods will help you to implement a total makeover of your body and mind. Some of these methods cannot be used immediately after a surgical operation. Also see the Natural Food Pyramid, which emphasizes a low-carcinogen diet, and a detailed discussion of this checklist in my book “How to Become Smarter” (Appendix VII).

There is no scientific proof that the combination of lifestyle changes below cures cancer. As mentioned above, there is no rigorous proof of conventional treatments either. The advantage of the lifestyle changes described below is that they are free of charge, relatively safe, make sense, deal with the cause of cancer, and some are supported by clinical scientific evidence. The decision is yours. Note that big and sudden changes in a lifestyle may cause temporary aberrations in metabolism, such as a rash, changes in sleep or weight, nosebleeds, unusual feelings, or an eye stye. At the end of each point, the following ratings are provided in brackets, for example, [1, a, activates CNS] means the most beneficial for health (the first place: the strongest effects and the largest number of beneficial effects), safe [a], and activates the central nervous system. Another example: [20, c] means 20th place, i.e., rather weak effects on health, dangerous [c], i.e., serious adverse effects are possible, and there are no well-defined effects on the central nervous system. Keep in mind that activation of the brain is not always desirable and usually weakens self-control. Therefore, the points below that increase activity need to be balanced with points that decrease activity.

1.    A healthy diverse diet (see the natural food pyramid in Chapter One of “How to Become Smarter”). Ignore your weight and don’t count calories (but try to avoid overeating: see the chewing techniques in Chapter One of that book). [5, a]

2.    Do brief cardio exercise (hormesis; twofold pulse acceleration) one to seven times a week, and you may add intensive physical exercise (30–60 minutes with sweating) once a month. A stationary bicycle in your home is the easiest way to exercise. [7, c, activates CNS]

3.    An adapted cold shower (approximately 20°C or 68°F) once a week (hormesis) when you are healthy, and several times a day when you are physically ill. A shower at 25°C is also beneficial but less effective. [1, a, activates CNS]

4.    Don’t smoke tobacco.

5.    Either no alcohol or moderate amounts at social events.

6.    Once a day or every other day, consume food products with exceptional therapeutic properties: turmeric and/or black seed. [10, a]

7.    Don’t take any artificial nutritional supplements, such as artificial vitamins and minerals. Do consume foods, spices, and herbs (or extracts) rich in micronutrients: small amounts of canned cod liver, beef liver, multi-vegetable juice, seaweeds, 1/3 glass of raw pomegranate or orange juice, and a multi-probiotic. [11, a]

8.    Complete colon cleansing once every 6–12 months, followed by a course of a good multi-probiotic. Try coffee enemas too (they can be done more frequently). [3, a, sedates CNS]

9.    Meditation or a brief nap. [41, a, sedates CNS]

10.        Use a tongue scraper at least once a week. Regarding dental health, see Endnote D1 in “How to Become Smarter.” [42, a]

11.        Do breath-holding exercises 1–7 times a week. This treatment is a moderate stressor for the system and as such should be beneficial for health, according to hormesis research. [12, a, sedates CNS]

12.        Practice short-term fasting regularly (hormesis). You can start with a water-only fast for 16 hours once a fortnight. Then you can increase the dose up to 24 hours per fortnight without water and food. [15, a, activates CNS]

13.        When facing a health problem, you should be skeptical about both conventional and alternative medicine. Except in the context of emergency medicine, you should be extremely suspicious of pharmaceutical and surgical treatments.

14.        If you wish to try some alternative or complementary medical treatment, do some research (here is a list of trustworthy websites, and I recommend greenmedinfo.com, www.westonaprice.org, price-pottenger.org, and lubodar.info), paying attention to scientific studies published in peer-reviewed journals.

15.        Raise your core body temperature to 38.0–38.5°C (100.5–101.3°F) once a month (hormesis) either in a hot bath at 40°C (104°F) or via intensive exercise. [13, b, sedates CNS]

16.        Do hyperventilation exercises once or twice a week (hormesis). [14, c, activates CNS]

17.        Go on a raw diet for one or two days a week. [4, a, activates CNS]

18.        Skip a night’s sleep once a month or every other month (hormesis). [18, b, activates CNS]

19.        Use a tanning bed or exposure to sunlight in small doses, e.g., 1 minute twice a day, six days a week (hormesis; natural source of vitamin D). [9, b, activates CNS]

20.        Raw lemon juice. It's another type of hormesis (an acidic agent) and must be prepared correctly. Pomegranate juice is a less effective alternative. [2, b]

21.        Use centuries-proven herbs every day or almost every day to adjust your mood, activity level, self-control, and sleep, for example, the valerian root, ginseng, and rhodiola. [20, a, sedates CNS, activates CNS]

22.        Consume beef fat or mutton fat (wet-rendered or boiled in water, not fried) as much as you can. This food is absolutely necessary for brain health (self-control, mood, sleep, getting rid of anger, etc.). Don't be scared, you won't gain weight. Everything you know about animal fat is flat wrong. [16, a, sedates CNS]

23.        Once a fortnight (or every day when you are ill), eat 1 or 2 tablespoons of pulverized or minced raw hot peppers and ginger. This is a good shock for your system (hormesis) and is a pain-killer. [6, a]

24.        Try the method of Galina Shatalova if you have any illness. [1, a, activates CNS]

25.        Discontinue all chemical drugs; some will have to be discontinued gradually. [2, b, activates CNS, sedates CNS]

26.        A prolonged raw diet that includes safe and socially acceptable raw animal foods. [8, a, normalizes CNS]

27.        A prolonged raw vegan diet. [8, a, activates CNS]

28.        A prolonged vegan diet without junk food. [9, a, activates CNS]

29.        Positive spiritual changes. [10, a]

30.        Prolonged fasting (hormesis). [13, c, activates CNS]

31.        Sauna (hormesis). The best remedy for an asthma attack. [17, b, sedates CNS]

32.        Losing excess body weight. [19, a, usually activates CNS]

33.        Think carefully about dangers and benefits of vaccines. See scientific evidence here and here. [21, a]

34.        A diet that excludes all foods cooked at high temperature (higher than the boiling point of water). [22, a, activates CNS]

35.        Several days of a ketogenic diet per month (hormesis) [23, a]

36.        Moving to a rural area. [24, a]

37.        Avoid tap water, even filtered one. Distilled water is recommended instead. [25, a]

38.        Exercises for the spine, especially if you have a sedentary job. [26, a]

39.        Low-intensity exercise, such as walking for 60 min. [27, a]

40.        Elimination diet for 1 to 2 weeks, first, try excluding typical allergens: dairy and cereal grains. Another good remedy for asthma. [28, a]

41.        Ingestion of small doses of hydrogen peroxide or ozone therapy (hormesis) [29, a]

42.        Winter swimming (hormesis) [30, c, activates CNS]

43.        Review household chemicals. [31, a]

44.        Ingestion of low doses of baking soda (hormesis; alkaline agent). [32, a]

45.        Eating raw honey daily. [33, b, sedates CNS]

46.        Eating pulverized nuts daily. [34, b, sedates CNS]

47.        Moderately high air temperature. [35, a, sedates CNS]

48.        Buy organic foods. [36, a]

49.        Exposure to low atmospheric pressure (hormesis). [37, a]

50.        Deep diving (hormesis; exposure to high pressure). [38, b]

51.        Parasite cleansing. [51, a]

52.        Grounding (earthing) [52, a]

53.        Avoidance of electromagnetic radiation. [53, a]

54.        Dousing oneself with sea water (hormesis, exposure to a hypertonic solution). [39, a]

55.        Lower air temperature in your home (15–18°C). [40, a, activates CNS]

For footnotes and scientific rationale, see the book “How to Become Smarter,” Appendix VII (A healthy lifestyle checklist). I recommend the following powerful combinations of the above techniques for rapid improvement of health: a) one day of a 100% raw diet, followed by a two-day dry fast and two more days of the raw diet, with simultaneous adapted cold showers twice a day; b) maximal stimulation of the central nervous system and immune system: (on an empty stomach) one glass of raw citrus juice, a one-time dose of ethanolic extract of ginseng, brief cardio exercise (twofold acceleration of pulse), and an adapted cold shower, in that order. Healthy people may experience hyperactivity and excessive impulsivity; to prevent these problems, it helps to do breath-holding exercises daily and to take a sedative herb three times a day (the dose can be increased up to 5-fold if necessary).

Finally, to get a different perspective on cancer research and cancer treatment, I encourage you to look into cancer treatments that are not officially considered “scientifically sound.” Science is currently so perverted by powerful nonacademic entities that you can never be certain what is scientifically valid and what is not, unless you do your own research. There are of course quacks out there, but there are also good ideas labeled as quackery by the corrupt scientific establishment and by institutional quacks. Life unfortunately is not simple, and finding the truth is not easy. Organizations that purport to fight pseudoscience are often psyops or industry-funded propaganda operations that will only confuse and mislead you.

The Matrix recruits various "skeptics" and "opponents of quackery" as follows: it finds highly skilled and educated people facing a prison term (often pedophiles) and makes an offer that they cannot refuse: work for the Matrix and spread disinformation on the Internet; if you agree, then the judicial system will "forgive" you, and no one will find out about your dirty past. Alternatively, you can go to prison. A necessary specialist who is clean can be entrapped with underage girls. Such "skeptics" then blackwash folk medicine and successful alternative medicine practitioners on the Internet around the clock. Not everything that the "skeptics" and "quack-busters" say is a lie; they copiously criticize and ridicule real charlatans and laughable theories in alternative medicine. Readers or listeners will swallow the disinfo only if it is mixed with the truth and half-truths. The disinfo agents are easy to recognize because they operate using a standard playbook: insults and name-calling (they are not afraid of lawsuits because all the legal expenses will be covered by their hidden sponsors), ridicule, one-sided skepticism (defense of the establishment and criticism of alternative medicine), extolling pharmacological and surgical treatments, silence about the gigantic fraudulent activities of the corporate healthcare industry, criticism and ridicule of conspiratorial thinking (but blind belief in and defense of the conspiracy theories advanced by the government and mass media that were "proven" by millionfold repetition via all information channels), and attachment of labels to people disagreeing with establishment-supported falsehoods (e.g., denier, conspiracy theorist, etc.).

Wikipedia is a bad source medical information and is heavily manipulated by the healthcare industry. By my estimates, only about 10–30% of scientific articles contain trustworthy information, and anybody who says that you should blindly trust science is either a fool or a disinfo agent. I do not endorse any of the sources listed below (except for Peter Gøtzsche), but it’s a good idea to keep an open mind and listen to different views at least for entertainment. In particular, when non-MDs criticize chemotherapy, they usually refer to cytotoxic chemotherapy (the one that causes your hair to fall out and makes you vomit profusely). There are other types of chemotherapy, and they do not have these adverse effects (but may cause other adverse effects). Do not blindly trust mainstream science and mainstream media (or alternative media). Life is complicated. When reading or listening to alternative medicine sources (may also be labeled as natural medicine, natural treatments, naturopathy, complementary medicine, etc.), keep in mind that these people may have useful ideas but a wrong explanation of the mechanism of action. Here are various alternative views on cancer:

Why Today's Cancer Treatments are Not Evidence-Based, Greenmedinfo.com

Peter Glidden, Cancer Confusion and 10 Questions To Ask Before Starting Cancer Treatments https://www.youtube.com/watch?v=qwdRQhzRF6c

Cancer: the Forbidden Cures, by Massimo Mazzucco

Dr Peter Gøtzsche on big pharma https://www.youtube.com/watch?v=dozpAshvtsA
 
New Study: Chemotherapy Can Help Spread Cancer, Cause More Aggressive Tumors https://www.youtube.com/watch?v=XUQSC2DZH6E

Robert E. Willner, The Cancer Solution, 1993.

Dying of ignorance, Richard Hall https://www.youtube.com/watch?v=quiChSoyNT0

Ty Bollinger, The Truth about Cancer

http://raypeat.com/articles/articles/cancer-disorder-energy.shtml

http://www.checktheevidence.com/pdf/The%20Cancer%20Business.pdf

Politics in Healing, Daniel Haley

Harry Hoxsey

Essiac tea

The Shatalova method

Galina S. Shatalova, M.D., Ph.D. (1916–2011) was a Russian neurosurgeon-turned-naturapath. When in medical school, she attended lectures of renowned physiologist Ivan Pavlov. As a surgeon, Shatalova served in two wars: the Russian-Finnish War and World War II. Her career in conventional medicine was going well, but she eventually abandoned conventional medicine and turned to mostly naturopathic methods sometime in the 1950s. She got disappointed with surgical methods and used to say that most of surgical interventions are unnecessary and harm patients. Although Dr. Shatalova did not specialize in oncology, she cured a number of cancer patients by her method, which she called the "System of Natural Healing." This method is effective not only against cancer but against many other diseases considered hopeless by conventional medicine, e.g., type I and type II diabetes, heart failure, renal failure, and others. She presented her numerous clinical cases to the medical establishment and to Soviet Union Communist Party leadership, but they either did not believe her or were not interested in changing the system convenient to the establishment. Thousands and perhaps tens of thousands of patients have regained health via Shatalova's books. The System of Natural Healing can be used individually without her assistance and is very inexpensive. Shatalova was a celebrity in the Soviet Union in the 1980s and appeared on various TV shows.

Shatalova's method consists of 1) spiritual changes (e.g., getting rid of anger, greed, and envy); 2) a mostly raw, plant-based diet including vegetable juices, honey, and herbs, with a substantial reduction in the amount of food (down to ~500 calories per day); 3) breathing exercises; 4) physical exercise including jogging; 5) whole-body cold-water procedures, e.g., gradual dousing (starting with legs and going up), which resembles the adapted cold shower; 6) something like forest therapy, i.e., living close to nature, away from cities, and getting in touch with nature. Shatalova was not a raw-fooder because she recommended eating slightly boiled whole cereal grains such as buckwheat, and she was not a strict vegan either because she allowed her patients to eat a tablespoon of cream occasionally (roughly once a fortnight). She noticed that people who adhere to her dietary regimen undergo some notable physiological changes, for example, their breathing rate decreases to approximately 5 cycles per minute at rest, and they gain unusual physical stamina as proven in supermarathons and lengthy hikes through a desert. The participants eating the officially recommended balanced diet dropped out of these experiments because of exhaustion. Shatalova criticized the official caloric theory of nutrition and believed that it is the root of all diseases. She was not a fan of pharmaceutical drugs in particular and of conventional medicine in general, which she called "symptomatic medicine." Typically, she made her patients discontinue all chemical drugs.

Galina Shatalova was a remarkable human being, healer, and charismatic speaker, and she had lived a long and healthy life. She still has many followers in Russia. In her book "Human Health," she describes a protocol that she recommends for self-treatment of cancer. This protocol includes the five points above plus the techniques developed by Katsuzo Nishi (six golden rules for health) and George Ohsawa (e.g., macrobiotics). Shatalova believed that to stop tumor growth, it is necessary to switch to the above-mentioned diet (see point #2) limited in calories and containing raw vegetable juices, especially beet juice. She also recommended some herbs as part of this cancer treatment. She was not enthusiastic about fasting and usually recommended this calorie-restricted regimen as a milder version of fasting. Her cancer treatment protocol makes a lot of sense because it involves comprehensive lifestyle changes. For more details, see this webpage. Despite her celebrity status, there is no Russian Wikipedia page of Galina Shatalova. This means that the Matrix cannot refute Shatalova's teachings and has no other choice but to keep silent about her.

I would like to say in conclusion that the System of Natural Healing is an excellent way to get rid of severe diseases such as cancer, but it may not be suitable as prophylaxis for all healthy people. In my experience, a vegan diet is incompatible with hard mental labor, for example, studying at a university, reading and writing of scientific articles, preparing for lectures, and writing of research grants. On the other hand, inclusion of raw animal foods into your diet, e.g., mutton fat (tail fat), eggs, fish oil, and small amounts of mild-cured fish, as well as greater amounts of pulverized nuts enable the hardest mental labor. Calorie restriction is incompatible with hard mental labor too. Even though Dr. Galina Shatalova had been a staunch vegetarian, i.e. did not eat meat in the second half of her life, she admitted in her book "Human Health" that Yakuts (eastern Siberian people) often live to be 100 years old because they eat sliced frozen raw meat and fish (Siberian sashimi).

The Gonzalez protocol

Brilliant physician and scientist Nicholas Gonzalez (born and died in the state of New York, 1947-2015), while enrolled at Cornell as a medical student, accidentally found a cancer treatment protocol developed by a dentist, William Donald Kelley. The method was based on personalized diets for general health improvement, consumption of pig pancreatic enzymes to destroy a tumor, and coffee enemas to help the liver to remove the resultant dead tumor cells from the body. Nicholas Gonzalez carefully documented and studied approximately a thousand cases of Kelley's patients, interviewed ~450 of these patients, found a scientific rationale, and then implemented this approach in his private medical practice (without losing his medical license) as well as published a number of scientific articles about this method. This is a colossal achievement, judging by the enormous resistance and lack of understanding that he faced from conventional medicine. He was unable to publish the clinical cases of Dr. Kelley and then his own in any scientific journals for approximately 15 years. Many of these easily verifiable clinical cases were simply amazing: for instance, patients with 4th-stage pancreatic cancer, hopeless according to conventional medicine, were alive and well 10-15 years after the above-mentioned course of treatment. The diagnosis was confirmed at well-known respectable healthcare institutions, such as Mayo Clinic. Dr. Gonzalez himself cured hundreds of patients of cancer via a similar protocol, among them Hollywood celebrities and powerful people, e.g., a NATO general. According to Dr. Gonzalez, the protocol did not always work, but the majority of cancer patients who adhered to the prescribed regimen either got rid of cancer completely or lived much longer than predicted by conventional medicine. Despite the unusual effectiveness of the Gonzalez protocol, he avoided hype, never held press conferences, and lived modestly. His partner in private practice, Dr. Linda Isaacs, has said that in spite of the elite clients, Nicholas Gonzalez had little money and charged moderate prices, suitable for average people.

Readers can learn more about the history and details of this cancer treatment from Dr. Gonzalez's lecture: https://www.youtube.com/watch?v=fVc8xwr_wfc.

In brief, in the early 1900s, a Scottish biologist (embryologist) of British origin by the name of John Beard discovered that cancer cells bear a striking resemblance to the trophoblast, i.e., the external cellular layer of an embryo. The trophoblast later turns into the placenta. The trophoblast behaves much like an invasive tumor, but after the trophoblast successfully gets implanted into the uterine wall (by acting like metastases), the trophoblast suddenly stops, and its cells stop dividing rapidly and behaving aggressively. John Beard had spent a lot of time searching for the signal that stops the "cancerous" behavior of the trophoblast and eventually concluded that this signal is activation of the primitive pancreas in the embryo/fetus. John Beard advanced the hypothesis that pancreatic enzymes can kill or stop cancer cells. He did not know back then that these enzymes are not degraded in the human alimentary tract and can get into the blood stream in one piece if they are taken orally. John Beard proposed intravenous injections of these enzymes, which was followed by more than a dozen scientific studies showing successful treatment of cancer by this method published by various physicians who got interested in John Beard's approach. Approximately at the same time, the famous scientist Marie Curie started advocating the use of radiation to treat cancer, and as a result, John Beard's enzymatic treatment of cancer was soon forgotten.

Approximately a century later, in 1999, Dr. Gonzalez published the first results of his practical application of the enzymatic treatment of cancer in a scientific journal. This was a small clinical trial involving 11 patients with pancreatic cancer. In 2007, he published (in a scientific journal) 31 clinical cases from his private practice: these patients had different types of cancer. Besides, in 2015, he published 112 of his clinical cases (patients with various types of cancer) in two books as well as 50 clinical cases of Dr. William Kelley in a separate book. Furthermore, in the 2000s, Dr. Gonzalez found the book about the enzymatic cancer treatment written by John Beard, digitized it, and published it anew. There were no obstacles because copyright had expired for books published before the 1920s, and the publisher had no objections anyway.

Nicholas Gonzalez has experienced first-hand how the Matrix and its fake science operate when he was one of investigators in another clinical trial of the enzymatic treatment of cancer, in the early 2000s. See the Literature section for more details.

Despite being in good health, Dr. Gonzalez died suddenly of a heart problem under suspicious circumstances in July 2015. Both before and after his death, so-called skeptics and "opponents of quackery" have insulted and blackwashed Nicholas Gonzalez on the Internet in every imaginable way. If you are curious, see what Wikipedia—the house organ of the Matrix—has to say about the Gonzalez protocol.

The Gonzalez protocol is still practiced by Dr. Gonzalez's long-time partner in private practice, Dr. Linda Isaacs. She moved her private oncological practice from New York City to Texas in 2019. You can get a consultation or become her patient: https://www.drlindai.com/. You can also learn more about the Gonzalez protocol on this website.

In the Literature section at the end of this booklet, readers can find some of the books and scientific articles written by Nicholas Gonzalez.

The book "One Answer to Cancer" by William Donald Kelley is available for free online, and by some estimates, helped tens of thousands of cancer patients. Thus, you can apply the Kelley/Gonzalez method yourself, as a home remedy. The only problem is that the testing for metabolic types is not available in that book. If you can't afford to get a consultation from Dr. Linda Isaacs, then see the text below, which describes a free do-it-yourself version of this testing. To the best of my knowledge, this method will yield the results fairly close to those of the proprietary tests from Kelley/Gonzalez.

First of all, you need to allow yourself to eat some healthy foods that you crave but may be avoiding for purely ideological reasons. If you want boiled fatty meat, then eat it as much as you want. In fact, I would advise eating boiled meat that is at least 50% fat (add beef or mutton fat) and avoid lean meat as plague. Second, at least one of Kelley's metabolic types does not tolerate raw foods well. Therefore, don't force yourself to eat raw foods if you strongly dislike them or if they make you feel worse. Boiled or steamed foods are fine. If you dislike meat or fruits, then don't force yourself to eat any of these. As Dr. Gonzalez used to say, finding the right diet is not difficult, just eat healthy foods that you want and enjoy (the wording is not exact).

One of Dr. Kelley's assistants, William Wolcott, has developed a paid long questionnaire on metabolic types, which has gained much popularity after the death of Dr. Kelley. Dr. Joseph Mercola later licensed and modified this test (with permission), making it simpler and free of charge. This adapted test is called Nutritional Typing and is available for free on Mercola.com. I recommend and endorse this test. Mercola's test yields one of three results: the Protein Type, Carb Type, or Mixed Type, which roughly correspond to the Parasympathetic Dominant (Carnivore) Group, Sympathetic Dominant (Vegetarian) Group, and Balanced Group, respectively, as defined by Kelley/Gonzalez, who subdivide these groups into 10 types (3 parasympathetic dominant types, 3 sympathetic dominant types, and 4 balanced types) and provide individualized dietary recommendations and advice about dietary supplements for each type. These recommendations are aimed at balancing the autonomic nervous system, i.e., the goal is to turn the para- or sympathetic nervous system dominance into a balanced functioning of the autonomic nervous system. The correction of this imbalance plays a major role in cancer treatment according to Kelley/Gonzalez. After you determine your basic group of metabolism by Mercola's test, you can read the descriptions of metabolic types in "One Answer to Cancer" to see which one describes you, more or less. After you determine your type, read the personalized dietary recommendations in the same book. Again, you need to listen to your body and choose the healthy foods that you want and crave. If this healthy diet then makes you feel better, we can conclude that you are on the right track, i.e., you've found the right diet for your metabolic type.

Joseph Mercola advises against dietary supplements in his Nutritional Typing brochures, unless there is a confirmed deficiency, and I agree. To simplify the anticancer lifestyle, you can replace any dietary supplement recommended by Kelley (e.g., some vitamin) with the corresponding food. It should be noted that there are lifestyle interventions other than foods that can strongly affect the parasympathetic nervous system and the sympathetic one. These are breath-holding exercises (parasympathetic effect), hyperventilation (sympathetic), brief cardio exercise (sympathetic), sedative herbs (parasympathetic), stimulant herbs (sympathetic), warm baths (mostly parasympathetic), and cold showers (mostly sympathetic), to name a few. If you are sympathetic dominant, then you need to choose treatments that have a parasympathetic effect to correct your imbalance, and vice versa. In case you are a balanced type, then you need to employ the treatments of both types, especially the ones that make you feel better.

As you will see in the next chapter, there are some surprising similarities between the sympathetic/parasympathetic imbalance of Kelley/Gonzalez and metabolic imbalances described by another great cancer doctor, Emanuel Revici. You can actually perform the physical and biochemical tests proposed by Revici to confirm your autonomic nervous system imbalance. Of course, you can also determine your metabolic type for a fee by means of Linda Isaacs' tests.

The Revici method and similarities with the Gonzalez protocol

A brilliant physician of Romanian descent who had done most of his work in the United States, Emanuel Revici (1896–1997), had developed his own unique successful approach to cancer treatment and proposed a theory suggesting that cancer can be caused by an imbalance between so-called anabolic and catabolic processes within the human body. Anabolic roughly means "building tissue" and catabolic roughly means "destruction or consumption of tissue." According to his theory, the anabolic imbalance corresponds to an excess of cholesterol or sterols, whereas the catabolic imbalance means an excess of fatty acids. Accordingly, he developed treatments based on administration (oral or by injection) of lipids or substances chemically derived from lipids. Initially, he experimented with cod liver oil and a placenta extract, but later started using pure chemical reagents. The uniqueness of Revici's approach is that his type of chemotherapy is nontoxic and is not designed to kill cancer cells. Rather, his "biologically guided chemotherapy" is designed to correct the imbalance between catabolic and anabolic processes within the human body. After that, the tumor and metastases are expected to gradually disappear by themselves.

The origin of his theory can be traced to a case of a 33-year-old woman at a terminal stage of gastric cancer who came under his care in 1927. Exploratory surgery revealed multiple inoperable metastases, and she was sent home because nothing could be done. She was pregnant at the time. Much to Revici's surprise, he encountered the same woman 2 years later in good health, completely free of cancer. This case got him thinking about what could cause such an unusual recovery. He hypothesized that the combination of pregnancy and sham surgery may have contributed to her recovery from cancer. He started experimenting with pregnant mice and sham surgery and found that some percentage of mice indeed recovered from cancer as a result of this combination. He then experimented with various extracts of the placenta (does this word ring a bell?), which were injected into mice. A lipid extract of the placenta (prepared by means of ethanol) yielded positive results in mice with cancer. Next, he started treating his cancer patients by this method. After some positive results, he tried administering fish oil, then fish oil fatty acids, and later various other lipids and lipid-derived substances, including cholesterol and an insaponifiable fraction of the placenta extract. Revici noticed that this treatment cured some patients (~5% of the cases) and produced a clinical improvement in others (10-20% of the cases); however, some patients got worse after this treatment, usually rapidly within a few days. Some patients who benefited from this method, at some point would stop responding to the treatment and then actually got worse rapidly. Some patients who got cured of cancer would experience recurrence of the cancer several years later, and the same treatment would no longer help them and actually made them worse. He hypothesized that cancer is a result of an imbalance of two opposing processes within the human body, and that correction of the imbalance may switch the body to the opposite extreme, which requires a different treatment. This theory was also supported by his observation that some cancer patients experience worse pain in the morning and feel better after a meal (anabolic imbalance), while other cancer patients experience worsening of pain in the evening and at night and feel worse after a meal (catabolic imbalance). He noticed that urine pH levels correlated with these pain patterns. In healthy people, urine pH is below 6.2 from 4 am to 4 pm and above 6.2 from 4 pm to 4 am. He noted that in cancer patients, this cycle is often disrupted, namely, that the anabolic imbalance corresponds to urine pH being stuck above 6.2, whereas the catabolic imbalance corresponds to pH below 6.2 all the time. His terminology is a little confusing: he calls the anabolic imbalance the "acid pattern of pain" (type A offbalance) because the acid part of the cycle is disrupted and urine pH is always alkaline or neutral (above 6.2); this imbalance means an excess of sterols or cholesterol in the human body. Conversely, he calls the catabolic imbalance the "alkaline pain pattern" (type D offbalance) because the alkaline part of the cycle is disrupted, and urine pH is always acidic or below 6.2; this imbalance means an excess of fatty acids.

Cancer patients with the anabolic imbalance benefited from substances that have a catabolic effect: fish oil (oral), fish oil fatty acids (injected), or injections of an acid fraction of lipids from the placenta extract (human or cow). On the other hand, cancer patients with the catabolic imbalance benefited from substances that have an anabolic effect: sterols (pure cholesterol was not very effective), butanol, glycerol, or an insaponifiable fraction of the placenta extract. Revici found that after several months, this approach may stop working because the patients would switch to the opposite imbalance, and then the opposite treatment would help them. Measurements of urine pH levels four times a day would help him determine the state of a patient's metabolism. After decades of clinical studies, Revici developed and tested his own cancer drugs with either catabolic or anabolic effects, and his rate of success gradually increased. By some estimates, his success rate in the 1980s and 1990s was 20% or higher among cancer patients who were mostly terminal or at stage 3 or 4. He dealt mostly with terminal cancer patients because his methods were not recognized officially, and accordingly, cancer patients were able and willing to find him only after conventional medicine gave up on them. It should be noted that his results cannot be explained by spontaneous remission because spontaneous remission of cancer without any treatment is extremely rare, perhaps one case in 50000 according to some estimates. The placebo effect cannot explain his results either because a) the placebo effect does not really exist; b) the placebo cannot cure cancer. Many cases of so-called spontaneous remission of cancer can be explained by alternative treatments. As mentioned above, truly spontaneous remission of cancer, i.e., in the absence of any treatment, is extremely rare or perhaps nonexistent.

In the 1950s, Revici's theory progressed to imbalances at different levels in the human body: systemic (whole body), tissue, and cellular. He developed different tests (Appendix II) that he believed identified catabolic/anabolic imbalances at different levels in the human body: the whole-body level, tissue level, and cellular level. Accordingly, he used different therapeutic agents to correct the imbalance at these different levels. These drugs are listed Appendix II. This targeted correction of imbalances often cured cancer or caused a clinical improvement, even at an advanced stage. The most remarkable effect is that cancer pain would often disappear or decrease substantially within several days, without pain-killers.

As you will see in Appendix II, the Revici method is rather complicated, but you can apply it yourself if you order some relevant medical tests. Revici's biographers have described some rather simple procedures that can help you to apply the Revici method at home, without any lab tests, as described below.

Anabolic imbalance (type A offbalance, urine is always neutral/alkaline, pH above 6.2, acid pattern of pain [acidic part of the cycle is disrupted: worse pain in the morning and improves after a meal], excess of sterols and cholesterol): low activity or sleepiness, somewhat higher body temperature.

The anabolic imbalance can be treated with catabolic agents/methods: hyperventilation exercise, cod liver oil (up to 2 teaspoons a day), and lemon juice. Avoid olive oil and other vegetable oils (they are anabolic according to Revici).

Catabolic imbalance (type D offbalance, urine is always acidic, pH below 6.2, alkaline pattern of pain [alkaline part of the cycle is disrupted: worse pain in the evening and gets worse after a meal], excess of fatty acids): high activity or insomnia, lowered body temperature.

The catabolic imbalance can be treated with anabolic agents/methods: breathing into a paper bag (alternatively, breath-holding exercise), honey, sweet fruits, boiled eggs (2 with each meal), and a warm bath (brief; a long one is not recommended, neither is a sauna). Olive oil is allowed. Any fried foods are to be avoided because they are catabolic. Note that lard and boiled beef/mutton fat (in comparison with eggs) contain 4-fold less cholesterol relative to fatty acids; therefore, they may be neutral or only weakly anabolic. In my experience, beef (or mutton) fat boiled in water slightly raises body weight and has a sedative effect; therefore, it is probably anabolic, at least weakly. Another noteworthy fact: coffee is an anabolic product according to Revici and should be useful against the catabolic imbalance, even though coffee increases activity (but pure caffeine is a catabolic product according to Revici).

William Kelley Eidem (no relation to William Donald Kelley) who wrote the most popular book about Dr. Revici and his method, "The Doctor Who Cures Cancer," listed many more foods in his book (Appendix II in my ebook). I mentioned above only selected foods: those that are healthy and have a relevant effect on the activity level. See Appendix II for more details. Revici did not tell his patients to follow a strict diet, but he recommended avoiding some strongly anabolic or catabolic foods depending on the kind of treatment the patients were receiving (Appendix II).

According to William Kelley Eidem, Revici proposed a rapid test for the imbalances: over the phone, he could ask a cancer patient to eat a couple of boiled eggs and drink a cup of regular coffee on an empty stomach. Because these are anabolic products, if the patient has the anabolic imbalance, then his/her cancer pain should increase within 10-15 minutes. Conversely, if the imbalance is catabolic, then the cancer pain should decrease within 10-15 minutes. According to William Kelley Eidem, Revici's associate, Dr. Robert Fishbein proposed two other rapid tests: breathing into a bag, which has an anabolic action (in my opinion breath-holding has the same effect) or hyperventilation, which has a catabolic effect. Of course, you can monitor your urine pH using pH strips. Revici asked his patients to do these measurements four times a day: 8 am, noon, 5 pm, and 9 pm. To obtain a reliable result, Revici would do various tests for three consecutive days.

Revici also recommended a sodium bicarbonate solution (an alkaline substance with a catabolic effect) for a temporary relief of anabolic pain. You can do some testing by taking this solution 2 or 3 times a day 30 min before a meal for 3 days and see how it affects your cancer pain. If you get worse, then you have the catabolic imbalance, but if you feel better, then you are on the right track because you are treating the anabolic imbalance with the catabolic substance. Paradoxically, a highly acidic substance, lemon juice, also has a catabolic effect and should be beneficial too against the anabolic imbalance. Revici believed that alkaline or acidic substances do not cause lasting changes in the catabolic/anabolic imbalance (including the urine pH pattern). Therefore, your main tools should be either fatty acids or sterols (or other Revici-recommended foods/substances) for the correction of your imbalance. My advice is to drink lemon juice through a straw because it can damage your teeth and lips. Diluting it 1:5 with water and taking it separately from baking soda are good ideas too. To prepare it, use a special citrus juicer and prevent any contact of this juice with metal because it can corrode even stainless steel and become contaminated with heavy metals. Use a ceramic knife to cut lemons. Apply coconut oil or some other oil to lips before drinking lemon juice. When you start drinking lemon juice regularly, you may temporarily experience cold sores; they may result from both acid damage and rearrangements in your immune system that cause dormant viruses to wake up. To make a sodium bicarbonate solution, place 1/4 to 1/2 teaspoon of baking soda into a glass, then pour half a glass of boiling water and let the solution cool to room temperature for 30 min.

According to William Kelley Eidem, Revici believed that a surgical intervention causes a strong catabolic reaction locally, followed by a whole-body anabolic shift; radiotherapy is always strongly catabolic; and different chemotherapeutic drugs can have different effects. Pain-killers and other drugs prescribed to cancer patients also have different effects. Please see Table XXIII in Chapter 16 of Revici's textbook. It is noteworthy that the cancer treatments whose metabolic effect aggravates your imbalance are likely to worsen your condition, including an increase in pain.

Just as Dr. Gonzalez, Dr. Revici has witnessed firsthand how the Matrix and its fake science operate. Namely, fake science was used to discredit his method not once but thrice (details can be found in "The Doctor Who Cures Cancer"). All three healers, Emanuel Revici, William Donald Kelley, and Nicholas Gonzalez, have been punished by the Matrix in other ways too, in that order.

Now, after studying both the Revici method and Kelley/Gonzalez method, I noticed that there are many similarities between the autonomic nervous system imbalance emphasized by Kelley/Gonzalez (sympathetic dominance and parasympathetic dominance) and the catabolic/anabolic imbalance addressed by Revici. There is no exact match if we look at the description of symptoms: Appendix B in "The Doctor Who Cures Cancer" and Chapter VIII in "One Answer to Cancer" by W.D. Kelley, sections "Group A – Sympathetic – Vegetarian Types" and "Group B – Parasympathetic – Carnivore Types." (The latter book is available for free on the Internet, and Appendix B of "The Doctor Who Cures Cancer" can be viewed using the "Look Inside!" feature of the print edition on Amazon.com.) Nevertheless, the most important features and treatment recommendations match between the sympathetic dominance and catabolic imbalance as well as between the parasympathetic dominance and anabolic imbalance (only matching features are listed below):

Catabolic (partially sympathetic) imbalance: high activity, insomnia, lower body temperature. Should avoid meat. Will not benefit from fish oil (Gonzalez recommended flaxseed oil instead for these "vegetarian types"). Fruits are recommended. A hot climate and warm baths should be beneficial. Eggs are recommended.

Anabolic (partially parasympathetic) imbalance: low activity, sleepiness, higher body temperature. Meat is recommended. Fish oil is recommended. Fruits are not recommended.

Balanced types in the Kelley/Gonzalez system probably have Revici-type imbalances only at one of the levels: cellular, tissue, or systemic (whole-body). A combination of the above-mentioned catabolic and anabolic interventions (plus pancreatic enzymes) is likely to be beneficial.

These observations lead me to believe that there is indeed some kind of metabolic imbalance involved in cancer, and you can simultaneously apply both Kelley/Gonzalez and Revici tests to identify this imbalance. Then, you can apply both methods to correct the imbalance, placing an emphasis on noncontradictory features of the two approaches.

Let's put it all together regarding the Revici method, the do-it-yourself version:

To test whether you have an anabolic or catabolic imbalance, try the following for 3 days (abort if you feel much worse before this period is over):

Catabolic agents/treatments: cod liver oil (up to 2 teaspoons a day); fresh lemon juice (as much as you can bear) before each meal; if you can't stand lemon juice, then you can drink a baking soda solution 30 min before each meal (for details, see the text above); hyperventilation exercise daily (don't overdo it because this exercise is not safe). Boiled meat, fish, grains, and vegetables are allowed, but not required, they have weak catabolic or almost neutral effects. During this period, AVOID or minimize anabolic agents/treatments listed below and white sugar, table salt, dairy, dairy fats, chocolate, alcohol, dietary supplements, herbs, and soy sauce.

If after 3 days of this catabolic regimen, your cancer pain is relieved and you feel significantly better, then you have the anabolic imbalance, and you need to continue this catabolic regimen (some requirements can be relaxed). If you get worse, then you have the catabolic imbalance, and you need to try the regimen that follows.

Anabolic agents/treatments: 2 eggs with each meal; one cup of regular coffee in the morning; a tablespoon of honey with each meal (if you can't tolerate it, then eat sweet fruits [or juices from sweet fruits] instead); a brief warm bath daily in the evening; breathing into a bag or breath-holding exercise (3 repeats per 10-minute session, one session a day). Dairy and boiled grains and vegetables are allowed, but not required. During this period, AVOID or minimize catabolic agents/treatments listed above and cold showers, high-intensity exercise, meat, fish, mayonnaise, fermented cheese, dietary supplements, herbs, and any fried foods.

If neither regimen had a significant effect on you, then you probably have an imbalance only at one of the levels: whole-body, tissue, or cellular, or perhaps the Revici method is not for you. Try other methods described in this book.

If one of these two approaches (either the catabolic regimen or anabolic regimen) helps you, then continue with this approach until it stops working. In particular, if you feel progressively worse for 3 days in a row, then you should switch to the opposite approach or do nothing for a week or two. Now is a good time to self-test your urine pH as described above or do some other Revici-type tests (see Appendix II). Don't switch more often than every 2 or 3 months. According to the clinical cases described in Revici's textbook, patients typically receive one kind of treatment for 6 to 24 months before they need to switch to the opposite treatment if ever.

Fasting to lose weight and tumors

Fasting is a strong catabolic treatment according to Revici's criteria; therefore, for cancer patients with a catabolic imbalance, fasting is not recommended. For cancer patients with an anabolic imbalance, fasting should be beneficial, but the problem is that prolonged fasting (more than 2 days) may impair the immune system, thereby accelerating tumor growth. Therefore, for some cancer patients, prolonged fasting will be harmful. It is known that a long fast benefits some cancer patients but not others. Experiments on laboratory rodents with implanted tumors indicate that caloric restriction or repeated brief fasting slows tumor growth, whereas prolonged fasting accelerates tumor growth (laboratory tumor models and results obtained in experiments on rodents are not always applicable to humans). If you have an anabolic imbalance (see the chapter about Revici), then brief fasting, i.e., 2 days every 1-2 weeks, will be beneficial. If you want to try prolonged fasting, then my advice is to use an immunostimulatory procedure, adapted cold shower, two or three times a day. I know and many followers of Porfiriy Ivanov's method know that cold hydrotherapy makes fasting much easier: it raises the low blood pressure, gives you energy, makes you feel better, etc.

You can try water-only fasting or dry fasting. During water-only fasting, you drink distilled water no more and no less than you want to. I recommend dry fasting, i.e., you don't drink and don't eat, but you can rinse your mouth with sea water (a 3.5% solution of sea salt) daily, daily adapted cold showers are allowed, as are occasional enemas. Dry fasting causes a faster weight loss and possibly faster tumor shrinkage, takes less time, gives your kidneys some rest, and is especially recommended when swelling is present and/or fluid accumulates in some body cavity or is excreted from some body part.

Remember that a long fast is a dangerous procedure and requires special tightly controlled conditions (a weight loss clinic or renting a separate apartment). Breaking a long fast incorrectly (e.g., with a steak or noodles) can cause serious damage to your health, even death. If a child or adolescent needs to fast more than 2 days, then the parent(s) living with him or her should fast too, to facilitate the procedure. Note that a raw diet reduces excess body weight and shrinks tumors and is easier and safer than fasting. Therefore, you may not need a long fast (I recommend short fasting once a fortnight, regardless of the state of health). A raw diet of course works more slowly than fasting does. If you have a rapidly progressing type of cancer, e.g., acute myelocytic leukemia, then you might consider dry fasting for a week with 3 days of a raw diet as a preparation phase. Then, do 2 weeks of a raw diet (which includes the exit phase) and another week of dry fasting. Likewise, if you have a large tumor, then you will shrink it faster if you apply several long fasts. Don't listen to surgeons who will be persuading you to remove a large tumor as soon as possible; there are self-serving greedy and dishonest surgeons unfortunately. A free operation (government-funded healthcare) does not mean a selfless act. The salary and career of a surgeon directly correlate with the number of operations he or she has performed. Additionally, the surgeon may be profiting from the use of equipment and drugs. People who sell medical treatments and equipment to a free healthcare system do not care about your health. The main fraudster that you should watch out for is the government. Any major surgical procedure is highly dangerous (much more dangerous than a long fast) with a high risk of serious complications, and many people die from anesthesia alone. In reality, you can live with a tumor and feel fine, and you can wait for several years until it gradually disappears when you lead an anticancer lifestyle. Haste makes waste.

There are three important phases of a long fast: preparation, fasting, and exit. During a long fast, you should go on vacation (covering the fasting and exit phases), and you should live under special conditions mentioned above. If you share an apartment or house with people who are not fasting, then you won't be able to fast for a long period, forget it. All temptations should be absent. Your fasting conditions should not require a struggle with yourself or will power. In particular, in the apartment where you will be fasting for a long period, there should be no food; the fridge should be empty.

Preparation phase. If you feel bad and have no energy, this means that you shouldn't start a long fast (more than 2 days). If you are emaciated (severely underweight), then fasting is not for you either. Try a raw diet for a week or two (10% of healthy boiled food is allowed) before a long fast. If time allows, you need to stay on a raw diet for at least the duration of the planned long water-only fast (twice the duration of a dry fast). If there is no time, 3 days of a raw diet is the minimum. Take adapted cold showers daily. Furthermore, if time allows, you can do cascade fasting, for example, 1 day of fasting, then two days of eating, then 2 days of fasting and 4 days of eating, followed by 4 days of fasting and 8 days of eating, etc. Immediately before a long fast, you need to take a laxative (or do breath-holding exercises) and do complete colon cleansing. If you feel well and full of energy, then you are ready for a long fast. Brief fasting does not require either the preparation phase or exit phase.

Fasting proper. During this phase, you can rest most of the time, but going outside or doing some work is allowed, only if you feel like it. You should stay away from places where food is present and people are eating or may be eating. A disadvantage of fasting is poor self-control and possible irritability; for this reason, you should either eliminate or severely restrict your access to the phone and internet. For example, put the key parts of the communications equipment in a safe, disassemble your computer and put the keys from the safe there; re-assemble the computer. It will take you 5-10 minutes to get your hands on the phone or internet; therefore, most impulses will be easy to control. It's a good idea to let your important contacts know in advance that you will be unavailable for the period covering the fast and exit and to set up an auto-response on the website of your e-mail provider. Change the message on your phone answering machine to tell callers that you are currently on vacation and will get back to them after a such-and-such date. Working on a computer disconnected from the internet, watching TV, reading books and magazines, and listening to the radio are OK. You should continue a long fast depending on how you feel. If you feel fine during a long fast, then continue fasting. If you start feeling bad during a long fast, then try one of the following: an adapted cold shower (which you should be taking 2 or 3 times a day during prolonged fasting); brief cardio exercise preceded by stretching; complete colon cleansing (without coffee and without a probiotic); hyperventilation exercise (careful); breath-holding exercise; scrape your tongue, brush your teeth with sea water (no toothpaste), and rinse your mouth with distilled water; douse yourself slowly with two buckets of sea water (tepid or warm); take a warm bath; take a sunbath or UV session; and try grounding. If none of the above helps, i.e., you still feel bad during a long fast, then it's a sign that fasting is counterproductive at this point and you should stop it. As mentioned above, fasting is harmful for some cancer patients, and the anabolic imbalance can switch to the catabolic imbalance, at which point you should change the cancer treatment regimen. Keep in mind the following rule of thumb: if you feel well during a fast, this means that the tumor is shrinking; if you feel bad for 12 hours or longer, then the tumor is growing. Start the exit procedure.

Exit phase. This gradual refeeding phase should last half as long as a water-only fast and just as long as a dry fast. During this exit phase, you gradually increase the amount of food and gradually add more difficult types of food. Your self-control is still impaired during this phase, and therefore the same restrictions apply as described above regarding the phone and internet use. The exit is the most stressful phase for your body, and doing it incorrectly will have serious consequences. Subdivide the exit phase into four stages of equal duration: 1) 50%-diluted freshly prepared fruit and/or vegetable juices, one glass three times a day; overeating during the first and/or second day of the exit phase is bad for your health; to prevent it, you can freeze any food and thaw only the allowed amount for each meal; on the second or third day, you can start consuming two glasses of diluted juices three times a day; diabetic patients can start with a diluted mixture of tomato and cucumber juices; patients who do not tolerate raw fruits and vegetables (some diseases of the pancreas) will probably tolerate them now because the pancreas had the time to rest and heal during the long fast; if not, try well-diluted raw honey (an even tablespoon per two glasses of water) or 50%-diluted boiled tomato and cucumber juices. This option is only for people who do not tolerate raw fruits and vegetables. Remember that it is unsafe to break a long fast with undiluted honey or protein or fatty foods. If the first food causes some problem, for example, you suddenly feel bad, get an acute stomachache, or become manic, then empty your stomach by vomiting immediately (put two fingers down your throat), then drink plenty of water and induce vomiting again, until your stomach is clean; try some other well-diluted food among those listed above; 2) whole fruit and vegetable juices or continue the same diluted food; 3) add whole fruits and vegetables, diluted honey, a diluted raw egg (one egg per four glasses of water, one glass per meal), boiled vegetables, boiled whole cereal grains (no seasonings of any kind), especially the upper jelly part of boiled oats; 4) add more raw eggs (can be undiluted), start consuming sedative herbs, raw scallops (one per meal), and about 10 g/day of mild-cured fish (not smoked). The exit phase is over, you can start eating health foods that are disallowed during the exit phase, e.g., raw tail fat, boiled fatty meat, boiled fish, boiled eggs, goat dairy, raw cow dairy, bone broth, fish oil, cold-pressed oils (coconut, olive, and flaxseed), raw pulverized nuts, etc.

We covered all the important points of a long fast. I should say that fasting is also a spiritual experience, where you are free from the rat race, noise, and distractions and get an opportunity to think about important topics. For more information about fasting, see these links (these authors recommend a somewhat different procedure, but I still endorse them):

https://www.healthpromoting.com/

 https://www.youtube.com/watch?v=Nl8Y5jV0hN0

 https://lubodar.info/kak-pravilno-provodit-golodanie/

 https://lubodar.info/suhoe-golodanie-panatseya-21-veka/

 https://syhoegolodanie.com/

You can do prolonged fasting yourself, but if you prefer advice or help of a professional, then find a physician or clinic specializing in fasting in your country.

Pungent chemotherapy

Revici's biographer, William Kelley Eidem (no relation to William Donald Kelley) claims that he has cured himself of testicular cancer by consuming hot peppers every day for some time, along with cod liver oil. Apparently, this shock therapy is another type of hormesis. Hot peppers contain a substance called capsaicin, which has analgesic and anticancer properties. Kelley Eidem recommended ginger if you can't tolerate hot peppers. Ginger too contains a number of analgesic and anticancer substances. When you eat this hot puree alone, you will stimulate your cardiovascular system and various mechanisms that get rid of nasal mucus. To prepare this mixture, wash ginger and peppers, and cut off the remainder of a stalk from the peppers, but don't peel the ginger. Cut them up and place them in equal amounts into a blender with a small amount of water. Store the resultant puree in a refrigerator. To put out the fire in your mouth, eat some oils or fats. When you have cancer or are in pain, you can eat 1-2 tablespoons of the hot mixture every day. If you are healthy, I do not recommend eating this pepper-ginger mixture more often than once a fortnight because in my experience, pungent foods tend to promote the feelings of anger. Kelley Eidem's recipe is described on his Hubpage, and you can find some feedback from cancer patients there too.

Nonrecommended alternative treatments of cancer

Life would be easy if all conventional treatments of cancer were useless, whereas all alternative treatments of cancer were effective. In reality, conventional medicine is effective in a small percentage of cases, while many if not most of alternative treatments have severe adverse effects, do not make sense, or are not different from placebos (which have been proven to be ineffective). The alternative treatments that should make you suspicious are not much different from conventional therapies. Here, I list some questionable alternative treatments and explain briefly what is wrong with them. Don't be fooled by published clinical trials. As explained in Appendix I, modern clinical trials are too easy to manipulate and therefore do not prove anything. Moreover, they are not designed to answer the crucial question "Can this treatment cure cancer?" Instead, modern clinical trials detect tiny improvements in some parameters of a disease, for example, tumor size or progression-free survival. It is safe to say that a magic bullet (a "miraculous chemical compound") and treatments designed to kill the tumor cannot cure cancer, with very rare exceptions mentioned in the next chapter. A tumor is not the cause of cancer, and not surprisingly, surgical removal of the tumor almost never cures the patient of cancer. Documented cases of cancer cure, when a person stays healthy and free of cancer for decades, are the result of changes in one's lifestyle, suggesting that cancer is caused by an incorrect lifestyle and the ensuing disoder of metabolism. Correcting the problems in metabolism helps the human body to eliminate the tumor(s) on its own.

·       GcMAF. This is an example of a magic bullet. Cancer is not caused by a lack of GcMAF. Natural immunostimulatory proteins like IL-2 and interferons have a ton of adverse effects when injected into humans, and the same should be true for GcMAF. Even though its creators have been persecuted by the Matrix, this does not necessarily mean that this treatment is effective. The Matrix tends to punish a person that goes against it, whether this person is right or wrong. The Matrix may be mistaken and perceive a useless cancer treatment as a threat to status quo. For comparison, pancreatin is not a magic bullet because it is a mixture of proteins (enzymes) isolated from the pig pancreas. There is evidence that cancer is either caused or aggravated by a lack of pancreatic enzymes. Pancreatin is not injected, it is taken orally; most of it is not destroyed by digestive processes in the stomach and duodenum. If you eat GcMAF, it will be destroyed in your stomach and will have little or no effect. GcMAF is expensive and difficult to find, whereas pancreatin is dirt-cheap and available in any pharmacy. To give another example, Essiac tea is not a magic bullet because it is a large mixture of natural compounds, almost food; it is cheap and easy to make. It should be as safe as food. Nonetheless, don't make Essiac tea your only anticancer treatment. For example, a combination of physical exercise, sunbathing, and Essiac tea should be more effective against cancer than each approach alone.

·       Laetrile, also known as vitamin B17. Another magic bullet. Its clinical trials have been disrupted by the Matrix, and we do not have good data about this drug. Again, just because the Matrix bans and criticizes something, this does not necessarily mean that the forbidden fruit is effective against cancer. A pure chemical, even of natural origin, cannot be good for your health. If you decide to pursue this approach, then you are better off eating apricot kernels, which are safe in moderate amounts. Don't make this your only anticancer treatment.

·       Insulin-potentiated chemotherapy. This approach is designed to kill the tumor rather than to correct the metabolic disorder. Therefore, it is unlikely to cure cancer. This method is less toxic than regular chemotherapy but is still toxic and kills healthy cells in addition to cancer cells. Conventional chemotherapy is known to be effective against a small number cancers. You need to find out if insulin-ptentiated chemotherapy has been tested against these cancers.

·       Megadoses of vitamin C. A pure chemical, even of natural origin, cannot be good for your health, especially in megadoses. Purified vitamins have known adverse effects. You are better off drinking lemon juice and consuming other vitamin C-rich juices and foods. Don't make this your only anticancer treatment.

·       Ketogenic diet. Lately, there is growing interest in ketogenic diets, and some authors are claiming that his diet may be effective against cancer. Dr. Nicholas Gonzalez has provided convincing arguments why a ketodiet is not helpful in cancer, and therefore you should not waste your time. His good friend, the famous diet doctor Robert Atkins, has spent many millions of dollars and several years on the testing of his ketogenic diet on cancer patients. Nothing good came out of it. Dr. Gonzalez also cited some examples indicating that ozone therapy is not effective against cancer (there is a temporary improvement followed by aggravation).

·       Homeopathy. This approach seems to be incompatible with the current scientific understanding of the world. Diluting a substance to the level where even a single molucule is not present in the solution does not make sense. Homeopathy is not different from a placebo.

·       Electromagnetic devices, such as Royal Rife's. This approach seems to be incompatible with the current scientific understanding of the world, in particular, Royal Rife believed that cancer is caused by microbes and if these microbes are killed, then cancer can be cured. This is another approach designed to kill the tumor.

·       Stanislaw Burzynski's treatment. There are some good scientific data that antineoplastons can neutralize tumor cells, and this approach is nontoxic. I find it plausible that individually chosen antineoplastons can cure cancer in some patients. Nevertheless, I cannot recommend this method because it is expensive, and the success rate cannot be high because lifestyle causes of cancer are not addressed.

·       Urinotherapy. There is no scientific rationale for this approach. I cannot say that it is natural or that it deals with some lifestyle causes of cancer. Stanislaw Burzynski often isolates antineoplastons from urine; therefore, this approach may work for some patients or perhaps it does not work at all. It is impossible to either prove or disprove this method for two reasons: 1) people who claim that urinotherapy has helped them to get rid of cancer have not used urinotherapy alone; 2) it is extremely unlikely that somebody will test this approach in a clinical trial as a single treatment of cancer (modern clinical trials do not prove anything anyway, see Appendix I). Save yourself the embarrassment and avoid this treatment.

·       Integrative cancer treatments. This means that conventional treatments of cancer (usually harmful and not effective against cancer) are combined with alternative treatments, which may or may not be beneficial, as explained above. Better do nothing.

·       Cannabis and related products (e.g., CBD hemp oil). This herb may be beneficial, but it is illegal in many geographic locations, and you cannot be certain that you are buying authentic cannabis or related products.

·       Severe hyperthermia (up to 42°C core body temperature). This approach is aimed at killing the tumor and is highly dangerous for the patient's health. Mild hyperthermia (38–38.5°C) makes sense as hormesis and will help to cure cancer when applied in combination with other lifestyle interventions. Experiments on laboratory animals show that heat shock does not extend the lifespan unless it is used rarely and in small doses. Therefore, I would not recommend using hyperthermia more frequently than once or twice a month.

·       Distance healing. This approach seems to be incompatible with the current scientific understanding of the world. Most likely, it is not different from a placebo, and placebos don't work. It's OK to try distance healing, but only if it is free of charge. I will admit that therapeutic touch may have some beneficial effects even though modern science cannot explain them, but in relation to cancer, therapeutic touch does not address the cause of the disease.

·       Psychological interventions. Many of these methods are based on magical thinking. You need to keep in mind that psychological interventions will help to cure cancer only as far as they can improve your lifestyle. For example, if you are obsessed with work and don't have time to take care of healthy nutrition, then getting rid of this obsession will be beneficial for your health. If you forgive your uncle who molested you when you were a child, this is unlikely to cure your cancer. Don't forgive him, and don't listen to dishonest people who want your money (or want to make money by accumulating clicks and likes). The fact that placebos do not work suggests that matter (the brain) controls the mind (consciousness), not the other way around. For instance, if you are living in a stressful soul-crushing environment, then moving to another environment will be beneficial for your health. The stress directly negatively affects your brain and therefore your physical health. If you cannot move to another environment, then no amount of psychological counseling will improve your health. Matter rules over the mind. Incidentally, you can get rid of anger by changing your diet; please see my book "How to Become Smarter."

·       Black salve. Another unsafe attempt to kill a tumor.

·       Other miraculous chemical compounds and treatments primarily designed to kill cancer cells rather than rectify the disorder of metabolism.

·       Applied kinesiology. This is a diagnostic method and a technique for testing the properties of foods and other substances. On the basis of this testing, a treatment is chosen. This approach seems to be incompatible with the current scientific understanding of the world.

Conclusions

Right now, the reader is probably overloaded with the information about various cancer treatments. I will present a brief list of recommended methods, starting from the most effective and well proven, on to the therapies that might work for cancer patients (insufficient evidence but good theory). You can get rid of cancer yourself through lifestyle changes, many people did. For example, see these pages:
 Youtube playlist 1
 Youtube playlist 2
 https://lubodar.info/rak-izlechim-bez-lekarstv/
 https://radicalremission.com/search/
 https://www.chrisbeatcancer.com/category/natural-survivor-stories/
 and do your own search via several search engines (duckduckgo.com, bing.com, google.com, yandex.ru, and rambler.ru).

If you prefer to get a consultation or be guided by a reputable physician using lifestyle-based treatments, then read on. Otherwise, skip the rest of this paragraph. It should be noted that I have never met any of the people below and I have no financial ties with them. If you can get in touch with Dr. Linda Isaacs in Texas, USA, to get a consultation or become her patient, then do it first (https://www.drlindai.com/). She continues to practice the safe and effective Gonzalez protocol. The method of Emanuel Revici is practiced by Dr. Lynn August, by the AIM Center in New Jersey, and by Revici Life Science Center in New York City, USA. Clinics practicing the Gerson method are also a good place for cancer patients. Some decent clinics offer a modified Gerson protocol (see https://www.baileyobrien.com/what-i-did). In Russia, I recommend Alexei Sterligov, M.D. (his cancer treatment protocol is described here) and Vita, which is a club of followers of the System of Natural Healing founded by Galina S. Shatalova (http://vitaclub.su/ru/shkola-zdorovya/gorodskaya-shkola-zdorovya). Besides, Mikhail Sovetov, M.D., is a Russian urologist and naturopath who is well familiar with Shatalova's method. If you can't afford these treatments and consultations, then you can follow the do-it-yourself approach outlined below.

Cytotoxic chemotherapy makes sense in the following situations: testicular cancer, gestational choriocarcinoma, Hodgkin disease, acute myelocytic leukemia, and some high-grade lymphomas. Note that the cancer can come back several years later; therefore, you still need to think about changing your lifestyle to address the cause of cancer. In other types of cancer, cytotoxic chemotherapy makes no sense and will kill you sooner than cancer and will worsen your quality of life.

Radiotherapy makes sense if the tumor blocks essential physiological functions and has to be shrunken before surgical resection. In other cases, radiotherapy is useless because it is a powerful carcinogen itself. The cancer will come back more aggressive. If it is known that radiotherapy is unusually effective against your type of cancer (in terms of patient survival), then you might consider this approach.

A surgical intervention is undoubtedly necessary when the tumor blocks essential physiological functions. At early stages of some tumors, e.g., colon cancer and breast cancer, surgical resection alone with high probability will cure the cancer. (Uterine cancer at stage I can also be treated effectively by conventional therapies.) Evidence is less impressive in most of other cancer types. The small or moderate benefit of surgical methods reported in scientific literature is most likely unreal and is a consequence of biases and distortions. A minor surgical intervention (usually without general anesthesia) is relatively safe and makes sense even if the known benefit is moderate. Keep in mind that both minor and major surgical interventions may promote metastases.

Cancer immunotherapy (costly protocols and therapeutics offered by conventional medicine): the small or moderate benefits of such methods demonstrated in scientific literature are most likely unreal and are a result of biases and distortions. You might consider this approach if it is known to be highly effective against your type of cancer (in terms of patient survival, not tumor size).

Targeted chemotherapy or targeted therapy: some drugs (they are in a small minority) are highly effective, for instance, Gleevec (imatinib). In general, use the principles outlined above.

Hormonal therapy of cancer: use the principles outlined above.

In the early 2000s, an American researcher named Ralph Moss carefully studied all the scientific papers on which the officially recommended treatments of non-small lung cancer were based. His research covered all four stages of this cancer. Despite the widespread notion that these treatments are based on solid scientific evidence, Ralph Moss concluded that surgical resection, radiotherapy, and cytotoxic chemotherapy of this cancer are not supported by reliable evidence. Randomized clinical trials were either absent or showed only a small benefit in terms of survival. During this project, Ralph Moss assumed that all these scientific papers contain 100% truthful information. As we shall see in Appendix I, this is a rather optimistic assumption that does not correspond to reality. You will do well to ask your oncologist to show you the official treatment guidelines for your cancer type and citations of the underlying scientific articles.

Now let's review home remedies for cancer (starting from the most effective and well proven). I also mention components of the autonomic nervous system in the text below because the Gonzalez protocol (and the Kelley method before it) is designed to balance the sympathetic and parasympathetic nervous systems by means of individualized diets and micronutrients. Both Nicholas Gonzalez and William Kelley believed that an imbalance of these systems should be corrected if you want to cure cancer. This imbalance roughly corresponds to catabolic/anabolic imbalance in Revici's theory of cancer.

1. Take pancreatin 3 times a day 30-60 min before a meal. For details, see the free book "One Answer to Cancer" by William Donald Kelley, which can be downloaded here. If you can afford a more expensive pancreatic product, then take Pancreas capsules (pig) from Nutricology (100-200 per day depending on body weight) or the raw pig pancreas processed as described in the section "The importance of raw organs..." above. Also 3 times a day 30-60 min before a meal. This approach helps your body to destroy the tumor and metastases. Doctors Nicholas Gonzalez and William Kelley have cured hundreds of cancer patients in this way (it is estimated that tens of thousands of cancer patients have cured themselves by following their approach). The scientific rationale can be found in the books and scientific articles by Dr. Gonzalez (more than 150 thoroughly described clinical cases).

2. Determine your metabolic type and Revici imbalance as described at the end of the chapters about Gonzalez and Revici. Follow the dietary recommendations of Revici (see that chapter) and/or William Donald Kelley (see his free book, "One Answer to Cancer"). You will feel better within days if you follow a diet consisting of simple unprocessed foods, i.e., boiled or raw food products from the following list: fruits, vegetables, mushrooms, seeds, nuts, raw honey (well diluted with water), eggs, fish, fatty meat, dairy, and boiled grains, in any combinations. Baked (e.g., bread), fried, and other types of foods that were heated above the boiling point of water are not allowed. Smoked foods are forbidden too (contain carcinogens). Seasonings and spices are not allowed either because they contain too many artificial chemicals (some exceptions are mentioned below). Obviously, junk food is to be avoided. See the natural nutrition pyramid in the book "How to Become Smarter," two levels: "sedative food" and "good food." Two effective anticancer protocols (Gerson and Gonzalez) are based on a strict diet excluding junk food among other things. The strict diet is recommended until recovery from cancer, after which the restrictions can be relaxed somewhat.

3. Instead of the Gonzalez/Kelley protocol, you can try Galina Shatalova's method. For details, see https://lubodar.info/sistema-estestvennogo-ozdorovleniya-shatalovoj/

4. If you find the Kelley/Gonzalez protocol too complicated and Shatalova's diet too restrictive, then try the raw diets described in one of the previous chapters.

5. Use a powder of raw turmeric as a spice or seasoning (two level teaspoons per day) in cool or warm food.

6. The adapted cold shower depending on your metabolic imbalance. Once a day if you feel well or several times a day otherwise. You can try ginseng once or twice a week. These treatments mostly activate the sympathetic nervous system (fight or flight) and therefore may not be beneficial if you have the sympathetic/catabolic imbalance. It is scientifically proven that cold hydrotherapy improves quality of life (reduces pain and fatigue). There is plenty of evidence of an immunostimulatory effect. Porfiriy Ivanov and many of his followers in Russia have claimed that the lifestyle including daily cold hydrotherapy (the 12-point system of Ivanov) helped them to get rid of cancer. Dr. Galina Shatalova has cured many patients of cancer, and her method includes cold hydrotherapy.

7. If there are problems with hyperactivity, you can take sedative herbs and raw honey every day and do breath-holding exercises daily too. The latter approach mostly activates the parasympathetic nervous system (rest and digest).

8. Depending on your temperament and how you feel, do brief cardio exercises (twofold pulse acceleration) 1–7 times a week. This approach mostly activates the sympathetic nervous system.

9. Raise your core body temperature to 38°C (100.4°F) once or twice a month in a hot bath (40°C or 104°F) or via intensive physical exercise. This approach mostly activates the parasympathetic nervous system and innate immunity against cancer cells. After (but not during) 30-40 min intensive exercise, your parasympathetic nervous system will dominate, and this method has a sedative effect. You can apply this treatment regardless of your metabolic imbalance because it's not everyday. Hyperthermia is gradually incorporated into oncological clinical practice. If you have the sympathetic/catabolic imbalance, then brief warm baths daily (core body temperature will not change) will be beneficial, especially against cancer pain.

10. Raw carrot puree (made with a juicer or powerful blender) or raw carrot juice one to four glasses per day, regardless of your metabolic imbalance. Two effective cancer treatment protocols (Gerson and Kelley/Gonzalez) include raw carrot juice daily.

11. If you don't feel well and if you suspect that the problem is dead tumor cells floating around your body (your tumor is shrinking), then try coffee enemas to stimulate liver function. Two effective cancer treatment protocols (Gerson and Kelley/Gonzalez) include daily coffee enemas.

12. Try eating raw hot peppers daily.

13. Use a tanning bed or vertical home solarium or take sun baths for 1-2 minutes on all sides up to twice a day.

14. Consume only raw food one or two days a week. The Gerson therapy is based on an almost 100% raw diet.

15. Eat a small amount (10 grams) of the raw beef liver or veal liver every day in the form of capsules or frozen-thawed 1-2 times. Two effective cancer treatment protocols (Gerson and Kelley/Gonzalez) include this product daily.

16. Take advantage of other methods for improving your health (see the chapter "55 ways to change your lifestyle...").

* * *

You have reached the end of this document. I hope this manual will help you to defeat cancer! I update this ebook from time to time, so feel free to download the latest version.

APPENDIX I: 37 ways to distort the results of a clinical trial and cancer statistics

As you can see below, there are too many ways to distort the results of a clinical trial. There are other tricks that we do not yet know about. Therefore, you should not believe any clinical trials of commercial products, especially trials sponsored by large corporations because they use all possible deceptive tricks all the time. These numerous tricks allow a drug company or device manufacturer to turn clinical findings upside down. Let’s say you see a research paper about a clinical trial showing a moderate or small positive effect of a drug with mild and few adverse effects. The correct interpretation of the results is as follows: multiply the size and number of adverse effects by three; then, attach the minus sign to the main finding (the seeming beneficial result) and multiply it by two. In other words, this drug in reality worsened the disease and caused adverse side effect on top of that. If a clinical trial shows that the drug “did not work” or “did not provide a benefit,” then the correct interpretation is that the drug worsened the disease so much that even the dozens of deceptive tricks did not help the authors to obtain positive results. On the other hand, a published positive result of a clinical trial may be believable in two situations: {1} the treatment showed extraordinary effectiveness in several studies (e.g., 90% of patients experienced complete remission, as seen with chemotherapy in some rare cancers) or {2} the treatment has no commercial value (e.g., physical exercise or another lifestyle change). In such cases, the adverse effects are still likely downplayed by the authors.

For starters, I will define some key terms. A clinical trial in the simplest format includes two groups of patients: one group takes the drug being tested, and the other group (called control group) does not take any drug or takes a placebo pill. After the clinical trial ends, the investigators compare the health state of the patients between the two groups and draw conclusions about the effectiveness of the drug. Randomization means that in the clinical trial, the patients were distributed between the two groups randomly, not however the investigators want to. For instance, randomization by weight means that the patients are distributed between the two groups (control and active drug) so that the average weight is approximately the same between the two groups (the process is still random and performed by some kind of software). Single blinding (or simply a "blinded trial") means that the clinical trial includes a placebo group and that none of the patients knows whether he/she takes the active drug or placebo. Double blinding (i.e. a "double-blind trial") indicates that the clinical trial involves single blinding as described above, and on top of that, the investigators processing and obtaining the clinical data do not know which patients belong to which group. An independent third party then deciphers the results of the trial. Statistical significance of the results is evidence that the results are not a fluke, i.e., they did not occur by chance (to be precise, the results with high probability are not caused by chance). Clinical significance (or a large effect size) means that the treatment substantially improves the health state of the patients; in other words, this result is not just a number on a piece of paper where the majority of patients do not feel any improvement. A clinical finding may be statistically significant but clinically insignificant. OK, it’s time to review the ways to distort the results of a clinical trial.

 1) A biased sponsor (a drug company) is looking for compliant investigators who will produce the desired results.  Roughly 90% of clinical trials are sponsored by the private industry (are biased from the start).

https://clinicaltrials.gov/

Amsterdam JD, McHenry LB, Jureidini JN: Industry-corrupted psychiatric trials. Psychiatr Pol  2017,51(6):993–1008.

Spielmans GI, Parry PI: From evidence-based medicine to marketing-based medicine: evidence from internal industry documents. Bioethical Inquiry 2010, 7:13–29.

The sponsor (drug company) is a client of a contract research organization (CRO), which often conducts a trial for the drug company. Thus, the CRO aims to please the client and cannot be trusted to obtain unbiased results. The sponsor typically gets the results that it paid for.

Heres S, Davis J, Maino K, Jetzinger E, Kissling W, Leucht S: Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: an exploratory analysis of head-to-head comparison studies of second-generation antipsychotics. Am J Psychiatry 2006, 163(2):185–194.

Lexchin J, Bero LA, Djulbegovic B, Clark O: Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ 2003,326(7400):1167–1170.

Turner E: Unraveling the Bundles of Research Bias: Is What you Read the Truth, the Whole Truth and Nothing but the Truth? Mad in America Continuing Education, Accessed October 7, 2018.

Wang AT, McCoy CP, Murad MH, Montori VM: Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. BMJ 2010, 340:c1344.

2) As a consequence of #1, people writing the research article are under pressure to put a positive spin on the results.  The abstract embellishes or distorts the results in the main text.  

Boutron I, Dutton S, Ravaud P, Altman DG. Reporting and Interpretation of Randomized Controlled Trials With Statistically Nonsignificant Results for Primary Outcomes. JAMA 2010, 303(20):2058–2064.

Alasbali, T. et al., 2009. Discrepancy between results and abstract conclusions in industry – vs nonindustry-funded studies comparing topical prostaglandins. Am J Ophthalmol, 147(1), 33–38.e2.

 3) The Results section embellishes or distorts the actual raw data.  

Boutron I, Dutton S, Ravaud P, Altman DG. Reporting and Interpretation of Randomized Controlled Trials With Statistically Nonsignificant Results for Primary Outcomes. JAMA 2010, 303(20):2058–2064.

 4) The original raw data in a clinical trial are often inaccessible  (kept secret permanently), thus enabling #2 and #3 above.

Eichler H-G, Abadie E, Breckenridge A, Leufkens H, Rasi G. Open Clinical Trial Data for All? A View from Regulators. PLoS Med 2012, 9(4):e1001202.

Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ 2015, 351:h4320.

5) Incorrect selection of patients for the trial; to be precise, participants in a typical clinical trial are not representative of the general population of patients: the trial participants will be taking only one drug and currently have only one disease. Only 5-15% of real-world patients are allowed to participate in a trial because eligibility criteria are too strict. A substantial percentage of real-world patients have several diseases and take three or more medications. Adverse effects of these drugs are later treated with additional drugs.  THEREFORE, THE RESULTS OF MOST TRIALS ARE NOT APPLICABLE TO REAL-WORLD PATIENTS.  

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

Rothwell PM. External validity of randomised controlled trials: ‘To whom do the results of this trial apply?’ Lancet 2005, 365(9453):82–93.

6) Selective publication of clinical trials (not publishing trials that yield negative results: so-called publication bias).

Stefaniak JD, Lam TCH, Sim NE, Al-Shahi Salman R, Breen DP: Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis. Eur J Neurol 2017, 24(8):1071–1076.

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R: Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008, 358(3):252–260.

Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B: Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications. BMJ 2003, 326(7400):1171–1173.

Howland RH: Publication bias and outcome reporting bias: agomelatine as a case example. J Psychosoc Nurs Ment Health Serv 2011, 49(9):11–14.

Eyding D, Lelgemann M, Grouven U, Härter M, Kromp M, Kaiser T, Kerekes MF, Gerken M, Wieseler B: Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. BMJ 2010, 341:c4737.

Turner EH, Knoepflmacher D, Shapley L: Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database. PLoS Med  2012, 9(3):e1001189.

Ghaemi SN: The failure to know what isn't known: negative publication bias with lamotrigine and a glimpse inside peer review. Evid Based Ment Health 2009,12(3):65–68.

 7) Measurement of parameters that do not matter to patients  (so-called surrogate measures), to make a useless drug appear beneficial. For example, a drug can be approved for cancer treatment if it shrinks the tumor, even if it worsens quality of life and does not extend life.

Shaughnessy AF, Slawson DC. What happened to the valid POEMs? A survey of review articles on the treatment of type 2 diabetes. BMJ 2003, 327(7409):266.

Nilsson S, Mölstad S, Karlberg C, Karlsson JE, Persson LG: No connection between the level of exposition to statins in the population and the incidence/mortality of acute myocardial infarction: an ecological study based on Sweden's municipalities. J Negat Results Biomed 2011, 10:6.

8) Presentation of relative metrics not absolute results. Relative metrics look much more impressive. For example, you may see in a scientific article that “addition of radiotherapy to surgery offers a relative reduction of recurrence risk by 20%.” Sounds great! But if you look at absolute metrics, this result is modest: The risk of recurrence of 5% is reduced to 4%. In other words, 100 people should suffer the adverse effects of radiotherapy in vain to prevent 1 case of cancer recurrence. The risks are not worth the tiny benefit. I used to get a flu shot every year in the fall until I looked at the evidence. I was appalled to find that virtually all studies about the effectiveness of influenza vaccines present the results in the deceptive relative way, by showing a relative risk reduction instead of absolute numbers. The absolute risk reduction is ridiculously small: an approximately 2% incidence of influenza is reduced to a 1% incidence. To be precise, 71 people should get a flu shot to prevent one case of influenza, assuming that the presented data are 100% truthful (unrealistic assumption). You should also keep in mind that dozens of other viruses cause influenza-like illnesses against which this vaccine cannot work. Furthermore, these effectiveness studies show that flu vaccines have failed to provide any benefit in some seasons and do not help some segments of the population. All the while, mass media are extolling flu shots and bashing anti-vaxxers.

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

Diamond DM, Ravnskov U: How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease. Expert Rev Clin Pharmacol  2015, 8(2):201–210.

Cochrane Review: Vaccines to prevent influenza in healthy adults. 2016. https://www.cochrane.org/CD001269/ARI_vaccines-prevent-influenza-healthy-adults

 9) Other unusual ways to analyze the data to hide adverse effects or exaggerate benefits.  

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

Montori VM, Jaeschke R, Schünemann HJ, Bhandari M, Brozek JL, Devereaux PJ, et al.: Users’ guide to detecting misleading claims in clinical research reports. BMJ 2004, 329(7474):1093–1096.

Safer DJ: Design and reporting modifications in industry-sponsored comparative psychopharmacology trials. J Nerv Ment Dis 2002, 190(9):583–592.

Gilbody S, Wahlbeck K, Adams C: Randomized controlled trials in schizophrenia: a critical perspective on the literature. Acta Psychiatr Scand 2002, 105:243–251.

 10) Trying to explain the lack of effectiveness of a drug by an “unusually strong placebo effect.”  Accordingly, the drug companies then design clinical trials that try to exclude “placebo-responders” or minimize their effect on the final results: the so-called sequential parallel comparison design. This is such an obvious bias: the whole purpose of such trials is to prove that the drug works even when it doesn’t. This approach is pure pseudoscience. Incidentally, the placebo effect does not exist, it is fully explained by random changes in the state of health and by the natural course of a disease. Therefore, there is no such thing as “placebo responders.”

Hróbjartsson A, Gøtzsche PC: Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010, (1):CD003974.

Hróbjartsson A, Gøtzsche PC: Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001, 344(21):1594–1602.

 11) Failing to mention that the use of a placebo is an imperfect and inexact method.  Patients often guess correctly that they are in the active-drug group because of the adverse effects of the drug. Blinding of investigators is not perfect either and usually fails because experienced physicians know the typical adverse effects and easily identify the patients taking the active drug. Therefore, double-blind randomized clinical trials should not be presented as rigorous and mathematically exact scientific proof. Additionally, because there is no such thing as a placebo effect, patients do not need to be blinded regarding which treatment they get. A no-treatment control group known to patients can be used when possible.

Hróbjartsson A, Gøtzsche PC: Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010, (1):CD003974.

Hróbjartsson A, Gøtzsche PC: Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001, 344(21):1594–1602.

Kirsch I: The emperor's new drugs: medication and placebo in the treatment of depression. Handb Exp Pharmacol 2014, 225:291–303.

12) Ghostwriting of scientific articles.  Let’s say a pharmaceutical company conducts a clinical trial through a contract research organization (CRO) and wants to publish the results. If it shows the real authors of the clinical trial, then the readers will not take the findings seriously because all the authors have massive conflicts of interest: they are employees of the drug company and CRO. To give more scientific weight to the research article, the drug company hires fake authors, i.e., academic physicians who work at a university and are not affiliated with the drug company. Now 10 to 20 independent respectable scientists appear as coauthors of the article, along with one or two real authors (employees of the private industry).

Amsterdam JD, McHenry LB, Jureidini JN: Industry-corrupted psychiatric trials. Psychiatr Pol  2017, 51(6):993–1008.

Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E: Study 329 continuation phase: Safety and efficacy of paroxetine and imipramine in extended treatment of adolescent major depression. Int J Risk Saf Med 2016, 28(3):143–161.

13) Comparison with a wrong dose of another drug.  The dose of the comparison drug is set too high if the drug company is trying to show that its product is safer, or the dose of the comparison drug is set too low when the drug company is trying to prove that its product is more effective.

Safer DJ. Design and reporting modifications in industry-sponsored comparative psychopharmacology trials. J Nerv Ment Dis 2002, 190(9):583–592.

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

14) Miscoding of data.  In a clinical trial of an antidepressant, patients may drop out for various reasons. Let’s say a patient commits suicide and she simultaneously had complaints of nausea. The drug company can register only nausea as an adverse effect and the reason for the dropout. This is a good way to hide serious adverse effects.

Maund E, Tendal B, Hróbjartsson A, Lundh A, Gøtzsche PC: Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study. BMJ  2014, 348:g3555.

Healy D: Time to abandon evidence-based medicine? YouTube.com, at 12 min in the video. Accessed December 26, 2017.

15) Mislocation of data. Adverse events that did not occur in the placebo group during the trial are falsely assigned to the placebo group. For example, before the trial, there is often a “washout” period, when the patients stop taking previously taken drugs and stay without any drugs for some time, so that the effects of the drug being tested are not mixed with the effects of the previously taken drug. Adverse events such as suicide that occur during this washout period will be incorrectly assigned to the placebo group by the drug company, even though the placebo treatment has not started yet. Similarly, after the trial, a patient from the placebo group may be put on some drug and will commit suicide. The drug company will falsely assign this suicide to the placebo group, so that the placebo group looks worse than the treatment group. Through mislocation and miscoding of data, adverse events are made to appear statistically insignificant. A drug company adds just enough false adverse events into the placebo group to make the difference between the placebo group and treatment group statistically insignificant (in terms of the adverse events). Readers of the study see that there is an increase in the number of adverse effects with the drug, but the drug company convinces the readers that this finding is an illusion because it is not statistically significant.

Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ  2015, 351:h4320.

Healy D: Time to abandon evidence-based medicine? YouTube.com, At 12 min 30 sec in the video. Accessed December 26, 2017.

 16) Misrepresenting adverse effects of drugs as symptoms of the disease.  Drug companies claim that suicide is a symptom of depression not the effect of their drugs. As pointed out by David Healy, clinical trials yield misleading results when both the drug and disease cause the same symptom. Through key opinion leaders, drug companies also have propagated the notion that cognitive deficits and flat affect are negative symptoms of schizophrenia rather than adverse effects of neuroleptic drugs. This notion is now in textbooks.

Not so bad pharma. David Healy’s review of the book Bad Pharma by Ben Goldacre.

Lacasse JR, Leo J: Serotonin and depression: a disconnect between the advertisements and the scientific literature. PLoS Med 2005, 2(12):e392.

17) Misrepresenting withdrawal effects of a drug as a relapse of the disease; alternatively, the use of abrupt discontinuation of a drug (with the ensuing withdrawal effects)  to make the placebo group look worse than the treatment group. This method also helps to hide adverse effects of a drug.

Tsai AC, Rosenlicht NZ, Jureidini JN, Parry PI, Spielmans GI, Healy D: Aripiprazole in the maintenance treatment of bipolar disorder: a critical review of the evidence and its dissemination into the scientific literature. PLoS Med 2011, 8(5):e1000434.

Récalt AM, Cohen D: Withdrawal Confounding in Randomized Controlled Trials of Antipsychotic, Antidepressant, and Stimulant Drugs, 2000-2017. Psychother Psychosom 2019, 88(2):105–113.

 18) Changing the declared hypothesis of the study after completion of the trial and the result is negative.  One hypothesis (so-called primary endpoint) is declared during registration of a trial with the government. Let’s say a clinical trial measures 15 clinical parameters in patients, and there are four methods to analyze statistical significance of the results. To obtain regulatory approval of the drug, one of these 15 clinical parameters must be declared as the main hypothesis (primary endpoint) before the trial. Suppose the main hypothesis turned out to be wrong after the trial is completed (according to all four methods of statistical analysis). In other words, the clinical trial yielded a negative result and the government agency will not approve this drug for this disease. Not to worry, the sponsors of the trial still have 56 more ways to win (15 x 4 = 60 combinations and minus 4). Because many different parameters are measured during the clinical trial, some of them will improve by chance. When the trial is published in a scientific journal, the authors falsely claim that they had a different hypothesis; they do not report the negative result, and instead they report this accidental positive result. (This approach is forbidden for obtaining approval of the FDA but is allowed for publication in a scientific journal.) Because of the way statistical significance is measured traditionally, one of 20 trials will produce a random meaningless but statistically significant result. Thus, in a clinical trial, the sponsors can obtain three statistically significant results automatically by design (15 x 4 = 60 combinations divided by 20). These results are most likely random and meaningless, but they will be reported as a real clinical finding. As you will see in the next trick, the sponsors/investigators actually have far more ways to win and can publish 20 to 50 original research papers from a single trial. The vast majority of these “scientific” findings of course are accidental and do not mean anything, but they serve as deceptive advertising for the drug in question. They can also be used to justify off-label prescription of the drug in question.

Roest AM, de Jonge P, Williams CD, de Vries YA, Schoevers RA, Turner EH: Reporting bias in clinical trials investigating the efficacy of second-generation antidepressants in the treatment of anxiety disorders: a report of 2 meta-analyses. JAMA Psychiatry 2015, 72(5):500–510.

McGauran N, Wieseler B, Kreis J, Schüler YB, Kölsch H, Kaiser T: Reporting bias in medical research - a narrative review. Trials 2010, 11:37.

Bourgeois FT, Murthy S, Mandl KD: Outcome reporting among drug trials registered in ClinicalTrials.gov. Ann Intern Med 2010, 153(3):158–166.

Lancee M, Lemmens CMC, Kahn RS, Vinkers CH, Luykx JJ: Outcome reporting bias in randomized-controlled trials investigating antipsychotic drugs. Transl Psychiatry  2017, 7(9):e1232.

 19) Analysis of subsets of patients with certain characteristics  (so-called subgroup analysis). In this way, you can always find something positive in a trial that produced a negative result. Let’s say you can find 10 subgroups in your study population of 1000 people (women who have had only one child, white males between ages of 40 and 50 who never smoked, etc.). Continuing our example from the previous trick, now we have 600 combinations (15 x 4 x 10) and approximately 30 of them will yield a statistically significant result automatically by design (600 divided by 20). Thus, 30 positive research articles can be published from a single clinical trial (this is so-called salami slicing). Virtually all these findings are due to chance, but the readers of these scientific studies will be led to believe that these are real benefits of the drug in question. Note that the government regulatory agency did not approve the drug but does nothing about these misleading scientific studies (yes, they know what’s going on).

Spielmans GI, Biehn TL, Sawrey DL: A case study of salami slicing: pooled analyses of duloxetine for depression. Psychother Psychosom 2010, 79(2):97–106.

 20) Clinical trials can be combined by enrolling the same patients in two or more trials. Adverse events in the treatment group of the first trial will be assigned to the placebo group in the second trial because those patients will be assigned to the placebo group in the second trial. Thus, the adverse events in this spurious placebo group will seem to be as bad as those in the treatment group. This is a good way to hide adverse effects of a drug. Using this technique, drug companies successfully obfuscated the fact that antidepressant drugs increase the risk of suicide. (That the name "antidepressants" is incorrect—because these drugs worsen depression and make it chronic—is a separate topic.)

Healy D: Time to abandon evidence-based medicine? YouTube.com, At 42 min in the video. Accessed December 26, 2017.

Whitaker R: Do Antidepressants Work? A People’s Review of the Evidence. Madinamerica.com, March 11, 2018.

21) Incorrect duration of a clinical trial.  For example, clinical trials of antidepressants usually do not last more than 6 weeks, but they are prescribed to real-world patients for several years, even for life. The drug company can also choose the duration of a trial so that the benefits exceed the adverse effects if it is known in advance that adverse effects appear much later than the beneficial effects or vice versa.

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

 22) Stopping a trial too early or too late (compared to the approved protocol).  This approach can help to find a random combination of results that is better than the results that will be obtained when the protocol is followed exactly. This approach can also help to hide adverse effects.

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

Califf RM, DeMets DL: Principles From Clinical Trials Relevant to Clinical Practice: Part I. Circulation 2002, 106(8):1015–1021.

Mueller PS, Montori VM, Bassler D, Koenig BA, Guyatt GH. Ethical Issues in Stopping Randomized Trials Early Because of Apparent Benefit. Annals Internal Med 2007, 146(12):878–881.

Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, et al. Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects: Systematic Review and Meta-regression Analysis. JAMA 2010, 303(12):1180–1187.

Montori VM, Devereaux PJ, Adhikari NKJ, Burns KEA, Eggert CH, Briel M, et al. Randomized Trials Stopped Early for Benefit: A Systematic Review. JAMA 2005, 294(17):2203–2209.

Lurie P, Wolfe SM. Misleading data analyses in salmeterol (SMART) study. Lancet 2005, 366(9493):1261–1262.

 23) Misrepresenting statistical significance as clinical significance when the effect size is too small.  In such cases, the study may say that the effect is “significant” but there is no discussion of effect size and clinical significance.

Kirsch I: The emperor's new drugs: medication and placebo in the treatment of depression. Handb Exp Pharmacol  2014, 225:291–303.

Gøtzsche PC, Young AH, Crace J: Does long term use of psychiatric drugs cause more harm than good? BMJ  2015, 350:h2435.

 24) Analyzing only the patients that completed the trial.  If all the patients are included in the final analysis, both those that dropped out and those that finished the clinical trial, then the results will be less impressive.

Turner E: Unraveling the Bundles of Research Bias: Is What you Read the Truth, the Whole Truth and Nothing but the Truth? Mad in America Continuing Education, Accessed October 7, 2018.

Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B: Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications. BMJ 2003, 326(7400):1171–1173.

25) During publication of a multicenter trial:  inclusion of data from a site that was disallowed by the FDA.  

Turner E: Unraveling the Bundles of Research Bias: Is What you Read the Truth, the Whole Truth and Nothing but the Truth? Mad in America Continuing Education, Accessed October 7, 2018.

26) Seeding trials.  The real purpose of such clinical trials is not rigorous testing of a drug, but to let as many physicians know about this drug as possible. It’s a purely marketing device. In this scenario, the trial includes too many principal investigators and too many small sites (each physician tests the drug only on a few patients).

Krumholz SD, Egilman DS, Ross JS. Study of neurontin: titrate to effect, profile of safety (STEPS) trial: a narrative account of a gabapentin seeding trial. Arch Intern Med 2011, 171(12):1100–1107.

 27) Healthy volunteer trials are not registered and are not published.  A lot of adverse effects are hidden there. This information helps drug companies to plan ahead how to design a clinical trial to best hide the adverse effects.

Goldacre B: Bad Pharma. 2013. Farrar, Straus and Giroux, 448 pp.

 28) Testing a drug against many related diseases without a valid rationale  (results on some diseases will be positive by chance).

Ioannidis JPA, Karassa FB. The need to consider the wider agenda in systematic reviews and meta-analyses: breadth, timing, and depth of the evidence. BMJ 2010, 341(1):c4875–c4875.

 29) Bribing as many physicians, scientific journals, and editorial board members as possible.  Various ploys are used that do not look like bribery, such as exorbitant speaker fees, multimillion royalties for useless patents, mass purchases of paper reprints from journals (nobody needs paper articles these days), and advertising in journals. In this way, even blatantly fraudulent studies will not be retracted because both the authors and the journal receive money from the drug company in question. These studies will continue to be cited and taken at face value. Chemotherapy drugs are a good example of this deeply rooted corruption: this treatment is so horrible and so defies logic that the healthcare industry had to go one step further and share profits from these drugs directly with physicians, to ensure that this awful therapeutic method stays in clinical practice. In the United States, profits from chemotherapy drugs represent the lion’s share of income for oncologists in private practice. Naturally, you should be skeptical when an oncologist recommends chemotherapy. (You are double-screwed actually, because these physicians do not have to declare this questionable income to patients.)

Lundh A, Barbateskovic M, Hróbjartsson A, Gøtzsche PC: Conflicts of interest at medical journals: the influence of industry-supported randomised trials on journal impact factors and revenue - cohort study. PLoS Med 2010, 7(10):e1000354.

Smith R. Medical Journals Are an Extension of the Marketing Arm of Pharmaceutical Companies. PLoS Med 2005, 2(5):e138.

Becker A, Dörter F, Eckhardt K, Viniol A, Baum E, Kochen MM, Lexchin J, Wegscheider K, Donner-Banzhoff N: The association between a journal's source of revenue and the drug recommendations made in the articles it publishes. CMAJ 2011, 183(5):544-548.

Handel AE, Patel SV, Pakpoor J, Ebers GC, Goldacre B, Ramagopalan SV: High reprint orders in medical journals and pharmaceutical industry funding: case-control study. BMJ 2012, 344(1):e4212–e4212.

Liu JJ, Bell CM, Matelski JJ, Detsky AS, Cram P: Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study. BMJ 2017, 359:j4619.

Amsterdam JD, McHenry L: The Paroxetine 352 Bipolar Study Revisited: Deconstruction of Corporate and Academic Misconduct. Journal of Scientific Practice and Integrity 2019, 1(1) DOI: 10.35122/jospi.2019.958452

Campbell EG, Gruen RL, Mountford J, Miller LG, Cleary PD, Blumenthal D: A national survey of physician-industry relationships. N Engl J Med 2007, 356(17):1742–1750.

MassDevice Staff: U-Wisc. ortho chair Zdeblick under fire for $25M relationship with Medtronic. MassDevice.com, Published January 2, 2012.

Gøtzsche PC: Our prescription drugs kill us in large numbers. Pol Arch Med Wewn  2014, 124(11):628–634.

 30) Changing the definition of the disease after the clinical trial. In this way, some patients can be shifted from the control group to the active-treatment group or vice versa. This approach can make the results look better than they actually are.

https://tinyurl.com/y5w53p5t

Thus, a large randomized controlled trial does not prove anything, it is a weapon of mass deception. Statistical methods are not needed to prove that a cancer treatment works. For instance, such a method can be considered effective if in at least one in 10 patients it causes a full recovery (the absence of cancer and a good general state of health) in 5 years or sooner, so that the person is still healthy and cancer free at the 5-year mark. As mentioned above, spontaneous remission of cancer can be regarded as nonexistent (approximately one case in 50000), whereas the placebo effect does not exist because it cannot cure cancer and is fully explained by random changes in the state of health and by the natural course of a disease. From the research papers in the last paragraph, we can conclude that the most prestigious scientific journals are in collusion with the healthcare industry and play a major role in the mass deception described above. Physicians reading these lines probably started guessing that most of what they know about medicine is false. We are living in an upside-down world, a technological dystopia, where officially recommended medical treatments make diseases worse, while the most authoritative scientific journals are the biggest source of disinformation. In reality, some diseases do not even exist, they have simply been made up (for instance, the high cholesterol level in blood) or have been redefined to include numerous healthy people (as was done with diabetes [blood sugar levels]). This phenomenon is known as disease mongering. Various costly high-tech treatments are prescribed to healthy people and make them sick. These adverse effects are then treated with other chemical drugs and devices. The usefulness of some achievements of modern medicine is clearly exaggerated: raw honey and garlic are antibiotics and had been known long before the discovery of penicillin.

Now let’s review the ways to distort statistics on cancer outcomes. One of the main selling points for the conventional treatments of cancer is that "huge progress has been made in the treatment of cancer in the last decades." Are we winning or losing the war on cancer? It’s not clear. It terms of curing cancer, quality of life, and patient survival, conventional medicine has probably treaded water in the last decades or made only miniscule headway in some directions. So, I give you the ways to distort cancer statistics:

 31) The use of relative statistics rather than absolute statistics on cancer survival.  This method allows you to dress up a 90% death rate of some cancer as a 90% relative survival rate.

Glidden P. Cancer confusion. Youtube.com, Accessed September 15, 2019.

32) Selective presentation of statistics. For example, keeping silent about the data showing that the prevalence of some types of cancer has increased, as has the mortality rate of the patients in question.

Glidden P. Cancer confusion. Youtube.com, Accessed September 15, 2019.

Epstein SS: Evaluation of the national cancer program and proposed reforms. Int J Health Serv 1993, 23(1):15–44.

In the same category is the silence about substantial risks for life and health due to conventional cancer treatments and dangers of conventional medicine in general. A certain percentage of cancer patients die of adverse effects of chemotherapy and complications of surgical operations. Radiotherapy causes new tumors. If you decided to undergo high-tech treatments, then you are entering a mine field.

James JT: A new, evidence-based estimate of patient harms associated with hospital care. J Patient Saf 2013, 9(3):122–128.

Starfield B: Is US health really the best in the world? JAMA 2000, 284(4):483–485.

Makary MA, Daniel M: Medical error-the third leading cause of death in the US. BMJ 2016, 353:i2139.

Panagioti M, Khan K, Keers RN, Abuzour A, Phipps D, Kontopantelis E, Bower P, Campbell S, Haneef R, Avery AJ, Ashcroft DM: Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ 2019, 366:l4185.

WHO: Patient safety, key facts. https://www.who.int/news-room/fact-sheets/detail/patient-safety, Accessed December 1, 2019.

Strauss I: Does Medicine Actually Make People Live Longer? Huffpost.com, January 10, 2019.

Batrinos ML: The length of life and eugeria in classical Greece. Hormones (Athens) 2008, 7(1):82–83.

Ruggeri A: Do we really live longer than our ancestors? BBC.com, October 3, 2018.

Gøtzsche PC: Our prescription drugs kill us in large numbers. Pol Arch Med Wewn 2014, 124(11):628–634.

Null G: Death by Medicine. (Documentary film.) Youtube.com, Accessed September 15, 2019.

Kirby Dick (director, writer), Amy Ziering (writer): The Bleeding Edge. (Documentary film.) 2018. Netflix.

33) The use of 5-year survival data  as an indicator of progress in the war on cancer. These data are uninformative and do not tell us whether a patient  still has cancer and whether he or she has good quality of life. People who die 5 years and 1 day after the diagnosis are counted as success, as are bed-ridden people who still have tumors at the 5-year mark.

 34) Some cancers are now diagnosed earlier, but effectiveness of treatments has not improved  (so-called lead time bias). If this factor is not taken into account when you calculate the 5-year survival rate, then it will seem that more people are alive 5 years after the diagnosis.

Seisen T, Trinh QD, Abdollah F: Could lead-time bias explain the apparent benefits of early salvage radiotherapy? Nat Rev Urol, 2017, 14(4):193–194.

 

 35) Some tumors pose a very low risk, and the mortality rate of these patients is not affected by conventional cancer treatments.  For instance, the 20-year mortality rate of patients with ductal carcinoma in situ is 3%, and surgical treatments and radiotherapy do not reduce this rate. Nonetheless, these nodules are treated by conventional methods, and the data then are added into cancer statistics as successful treatment. If these incorrect statistics are used to calculate the 5-year survival rate, then it will seem as if conventional medicine has made huge progress.

Narod SA et al: Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma in Situ. JAMA Oncol 1(7):888–896.

 36) Environmental and lifestyle factors unrelated to conventional anticancer treatments are ignored.  The population now smokes much less than it did decades ago. Asbestos is now used much less in building materials. Thus, fewer people die of lung cancer and mesothelioma. This does not necessarily mean that surgical resection, chemotherapy, immunotherapy, and radiotherapy are now more effective.

37)  Complementary and alternative medicine is not taken into account  when the success in the war on cancer is evaluated. Up to 83% of cancer patients nowadays use various nonconventional treatments in addition to or instead of conventional ones. This rate probably changed over time and the effectiveness of such methods probably increased on average. Before you say that all this alternative stuff should be ignored because it doesn’t work, please review the literature section at the end of this book. I admit that many alternative cancer treatments do not make sense and probably do not work, but some alternative therapies have a good scientific rationale and well-documented effectiveness and have been designed by well-educated people (Gerson therapy, Gonzalez protocol, and the William Kelley method).

Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M: How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther 2012, 11(3):187–203.

* * *

You have probably heard that “Alternative therapies do not work because a treatment that is proven to work becomes conventional medicine.” This is pure nonsense of course if you have read the 36 points above.

The benefit of a treatment can be hypothesized but can never be proven rigorously. The people who want to find out the truth cannot conduct a large clinical trial. On the other hand, the people who can conduct large clinical trials worry about their income, social status, and/or renewal of research grants and therefore want to obtain one or the other result rather than find out the truth. The vast majority of clinical trials are conducted by people who want to, are able to, and do deliberately distort clinical data to obtain a desired result. A typical clinical trial is biased from top to bottom: for example, the initiator is a private sponsor who strives to sell something and wants to advertise this product by means of a clinical trial. There is always far more evidence that was distorted by the biases of big money and power in comparison with unbiased evidence. What matters is the quality not quantity of scientific arguments. Among the physician-scientists who are seemingly unbiased and uncorrupted, there may be people who work in collusion with the healthcare industry. If you do not conduct your own investigation, then you can never be sure what is really going on. Big money and power can always fabricate and present "an overwhelming amount of evidence" against the truth to further enhance own status, while persuading the population in every imaginable way that there are no conspiracies in the government and between the government agencies and big business. Intelligent people are skeptical about everything that the government and mass media are saying, but many smartest people have been successfully brainwashed to never think about any conspiracies. These people allow only the government and mass media to think and talk about conspiracies and blindly believe these conspiracy theories. Incidentally, the absence of a conspiracy is also a theory, and often a weaker one: ask people working in counterintelligence or prosecutors dealing with group crimes.

Thus, a clinical trial is useless as scientific evidence. I am tempted to say that a small clinical trial of noncommercial treatments (e.g., herbs or lifestyle changes) may yield plausible results. This is still a dead end, because if these findings encroach on the interests of powers that be, then the latter can openly or secretly sponsor clinical trials "disproving" inconvenient facts.

It is worthwhile to take into account ethical qualities of the physician conducting a clinical trial or describing clinical cases. Another important criterion is whether the proposed treatment makes scientific sense and addresses the cause of an illness. For instance, it is common knowledge in conventional medicine that patients with 4th-stage pancreatic cancer do not live longer than several months. Kelley's and Gonzalez's clinical cases include such patients who have lived decades afterwards. Gonzalez and Gerson did not strive to get rich and lived modestly; both were principled men of ideas who suffered for their ideas. Their methods are based on a logical theory that addresses a cause of cancer. For comparison, scientific papers about chemotherapy are chockful of deceptive tricks, and their authors and sponsors are obviously motivated only by material gain. Chemotherapy makes no sense and does not address the cause of cancer. A surgical intervention makes sense but is a dangerous procedure and does not address the cause of the tumor either.

What's a patient to do in this situation? Choose unpatented, cheap, nonpharmacological, and safe treatments such as well-known herbs, therapeutic foods, and lifestyle changes and test them on yourself, don't wait until the government or scientists will prove the benefits of these therapies for you (see the chapter "55 ways to change your lifestyle..."). Search for the cause of your illness in your lifestyle and environment. Diseases that have an authentic molecular cause (such as monogenic diseases) are rare in comparison with diseases that are caused by environmental and lifestyle factors. If you cannot find the answers yourself, then find an honest physician who has no illusions about the modern healthcare system and who does not receive various "incentives" from pharmaceutical companies or medical device manufacturers for treating patients in a certain way. If a treatment is free and safe and makes sense, then you don't need any clinical trials: simply try it yourself. You should believe only the results that you obtained yourself, because people tend to lie for selfish reasons, and you should not entrust your health to anyone, especially the government and big business. There are certain individual differences among patients with the same disease: what helps you may not work for other people. Some people have several illnesses, others cannot implement some lifestyle changes because of work or family circumstances, and still others may simply not like the proposed regimen and may prefer something else, not to mention genetic differences among humans. There is an infinite number of combinations of herbs, lifestyle changes, and therapeutic foods and their doses. Therefore, a person can prove the effectiveness of a treatment to oneself but not to other people.

Purified chemicals (both prescription drugs and natural substances) will worsen your health even if they improve some physiological function. The reason is that pure chemicals are foreign to your body, which has evolutionarily adapted to take in natural foods, natural drinks, and water. Hormesis (the paradoxical effect of small doses) is probably the only exception here. Chemical drugs (such as an epinephrine injection) are useful in emergency medicine, but the treatment of chronic diseases by means of chemical drugs is gradual destruction of health.

As explained below, the world is ruled by evil through mass deception. If you feel well, but the whole Matrix scares you into taking some chemical drug or into undergoing some medical procedure, or else "you will die," then you need to find the critics (physicians or scientists) of this treatment and of the underlying theory. You need to carefully examine the scientific evidence that they offer. If this contrary evidence is unbiased and logical, then you should ignore the "overwhelming amount of proof" behind this questionable treatment because this proof has been fabricated. Again, what matters is the quality not quantity of scientific evidence. One unbiased logical opinion of a highly qualified specialist carries greater weight than thousands of biased scientific articles. Most people believe a lie handed down by powers that be, simply because they heard it every day, all their lives, from all mass media. You shouldn't trust organizations that keep secrets from you because they don't do this for your benefit. Logical reasoning suggests that if a government is simultaneously allowed to keep secrets and use force, then the ruling elite can ignore the law and deceive and use the population in any way the elite wants with impunity. The existence of secret laws means that the constitution does not work and that secrecy is maintained via draconian rules. This type of government is a conspiracy against the population. Under this system, unethical behavior enhances the ruling elite's power, whereas ethical behavior leads to a loss of power. For example, knowledge is power, whereas honest sharing of knowledge means sharing and losing power. If we assume that self-interest is the norm for humans, then the top priority for the government is retention and accumulation of power, which requires deception and infiltration. Thus, almost all officially endorsed knowledge about politically and economically important topics is false (medicine, some areas of physics, structure of the government, mass media, history, etc.). Because mass media determine the outcome of elections, voters who believe mass media (almost every voter) cannot make their own choice, and candidates that serve the population almost never win. Elected officials do not have real power anyway; all power eventually accumulates in the part of the government that can use force secretly.

APPENDIX II: Revici's medical tests and therapeutic agents

To determine an anabolic/catabolic imbalance at the systemic (whole-body) level and organ level: measurement of urine specific gravity, core body temperature;
 At the metazoic level (extracellular compartment, serum, and lymph): measurement of urine surface tension;
 At the tissue level: measurement of urine pH, determination of the pain pattern;
 Cellular level (membranes): measurement of the calcium excretion index;
 Cellular level (cytoplasm): measurement of serum potassium and total-blood potassium levels.
 
 For details, see Table XXII in Chapter 16 of Revici’s book "Research in Physiopathology as a Basis of Guided Chemotherapy With Special Applications to Cancer."

 The anabolic imbalance at the cellular level is treated with selenium preparations and epichlorohydrin;
 at the tissue level with fatty acids, tetralin persulfides, magnesium thiosulfate, and hydropersulfides;
 at the systemic, metazoic, and organ levels with magnesium or sodium thiosulfate and propionic aldehyde.

 The catabolic imbalance at the cellular level is treated with heptanol;
 at the tissue level with polyunsaturated alcohols, unsaponifiable fraction of pig liver, glycerol, and butanol;
 at the systemic, metazoic, and organ levels with glycerophosphoric or lactic acid.

 For doses and routes of administration, please see Chapter 16 in Revici’s textbook. The data in his textbook are dated 1961. I am certain that his treatments have advanced between 1961 and 1993. For this reason, it would be best to get the Revici treatment from a specialist (Dr. Lynn August or the AIM Center in New Jersey or Revici Life Science Center in New York City, USA) or get a consultation there if you can.

According to William Kelley Eidem's book "The Doctor Who Cures Cancer," Revici recommended that the following catabolic foods be minimized or avoided when you have the catabolic imbalance: meat, bread, fish, fish oil, and fried foods; if you have an anabolic imbalance, you should avoid or minimize anabolic foods: dairy and dairy fat, honey, fruits, boiled eggs, coffee, and vegetable oils. The complete list can be found in Chapter 33 of "The Doctor Who Cures Cancer." The list of anabolic/catabolic effects of various drugs and substances can be found at the same location and in Chapter 16 (Table XXIII) of Emanuel Revici's book "Research in Physiopathology as a Basis of Guided Chemotherapy With Special Applications to Cancer" (1961).

 

Literature

Detailed scientific argumentation and literary references regarding cold showers and other methods are found in my other ebooks “Fresh ideas for clinicians regarding improvement of quality of life of cancer patients” (link) and “How to Become Smarter” (link). For the present book, studies related to each section are listed below (in the order of discussion):

Introduction

Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J:
A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017). PM R 2017, 9(9S2):S347–S384.

Unlu A, Nayir E, Dogukan Kalenderoglu M, Kirca O, Ozdogan M:
Curcumin (Turmeric) and cancer. J BUON 2016 21(5):1050-1060.

Hutchins-Wolfbrandt A, Mistry AM:
Dietary turmeric potentially reduces the risk of cancer. Asian Pac J Cancer Prev 2011 12(12):3169-3173.

van der Heijden AG, Dewhirst MW:
Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. Int J Hyperthermia 2016 32(4):434-445.

Challis GB, Stam HJ:
The spontaneous regression of cancer: a review of cases from 1900 to 1987. Acta Oncologica 1990 29:545-550.

Radoja S:
Possible stimulation of antitumor immunity using repeated cold stress: a hypothesis. Infect Agent Cancer 2007, 2:20.

Holloszy JO, Smith EK:
Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory.” J Appl Physiol 1986, 61(5):1656–1660.

Ushijima M, Ogata Y, Tsuda H, Akagi Y, Matono K, Shirouzu K:
Demethylation effect of the antineoplaston AS2-1 on genes in colon cancer cells. Oncol Rep 2014, 31(1):19–26.

Turner KA:
Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors. Ph.D. dissertation, University of California at Berkeley. 2010, 98 pp.

da Silva I, da Costa Vieira R, Stella C, Loturco E, Carvalho AL, Veo C, Neto C, Silva SM, D'Amora P, Salzgeber M, Matos D, Silva CR, Oliveira JR, Rabelo I, Yamakawa P, Maciel R, Biscolla R, Chiamolera M, Fraietta R, Reis F, Mori M, Marchioni D, Carioca A, Maciel G, Tomioka R, Baracat E, Silva C, Granato C, Diaz R, Scarpellini B, Egle D, Fiegl H, Himmel I, Troi C, Nagourney R:
Inborn-like errors of metabolism are determinants of breast cancer risk, clinical response and survival: a study of human biochemical individuality. Oncotarget 2018, 9(60):31664-31681.

Rasnick D:
Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy. Cancer Genet Cytogenet 2002, 136(1):66–72.

Savage P, Stebbing J, Bower M, Crook T:
Why does cytotoxic chemotherapy cure only some cancers? Nat Clin Pract Oncol 2009, 6(1):43–52.

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Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med 2017, 9(397):eaan0026.

Morgan G, Ward R, Barton M:
The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol) 2004, 16(8):549–560.

Smith TJ, Hillner BE, Desch CE:
Efficacy and cost-effectiveness of cancer treatment: rational allocation of resources based on decision analysis. J Natl Cancer Inst 1993, 85(18):1460–1474.

Gøtzsche PC:
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Lexchin J, Bero LA, Djulbegovic B, Clark O:
Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ 2003, 326(7400):1167–1170.

Probst P, Grummich K, Harnoss JC, Hüttner FJ, Jensen K, Braun S, Kieser M, Ulrich A, Büchler MW, Diener MK:
Placebo-controlled trials in surgery: A systematic review and meta-analysis. Medicine (Baltimore) 2016, 95(17):e3516.

Benjamin DJ:
The efficacy of surgical treatment of cancer - 20 years later. Med Hypotheses 2014, 82(4):412-420.

Ezzo J, Bausell B, Moerman DE, Berman B, Hadhazy V:
Reviewing the reviews. How strong is the evidence? How clear are the conclusions? Int J Technol Assess Health Care 2001, 17(4):457–466.

https://bestpractice.bmj.com/info/evidence-information/ BMJ Best Practice 2018.

Candelario DM, Vazquez V, Jackson W, Reilly T:
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Wikipedia: A disinformation operation? Swiss Policy Research, June 2020.

Healy D:
Time to abandon evidence-based medicine? YouTube.com, Accessed December 26, 2017.

Overall, Wikipedia is a bad source of information, but some articles on noncontroversial topics can be useful.
https://en.wikipedia.org/wiki/Superseded_scientific_theories

Ioannidis JP:
Why most published research findings are false. PLoS Med 2005, 2(8):e124.

Open Science Collaboration:
Estimating the reproducibility of psychological science. Science 2015, 349(6251):aac4716.

Begley CG, Ellis LM:
Drug development: Raise standards for preclinical cancer research. Nature 2012, 483(7391):531–533.

Ioannidis JP:
How to make more published research true. PLoS ONE 2014, 11(10):e1001747.

Belluz J and Hoffman S:
Let's stop pretending peer review works. Vox.com December 7, 2015.

Lundh A, Barbateskovic M, Hróbjartsson A, Gøtzsche PC:
Conflicts of interest at medical journals: the influence of industry-supported randomised trials on journal impact factors and revenue - cohort study. PLoS Med 2010, 7(10):e1000354.

Liu JJ, Bell CM, Matelski JJ, Detsky AS, Cram P:
Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study. BMJ 2017, 359:j4619.

Campbell EG, Gruen RL, Mountford J, Miller LG, Cleary PD, Blumenthal D:
A national survey of physician-industry relationships. N Engl J Med 2007, 356(17):1742–1750.

Starfield B:
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Makary MA, Daniel M:
Medical error-the third leading cause of death in the US. BMJ 2016, 353:i2139.

James JT:
A new, evidence-based estimate of patient harms associated with hospital care. J Patient Saf 2013, 9(3):122–128.

Panagioti M, Khan K, Keers RN, Abuzour A, Phipps D, Kontopantelis E, Bower P, Campbell S, Haneef R, Avery AJ, Ashcroft DM:
Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ 2019, 366:l4185.

WHO: Patient safety, key facts.
https://www.who.int/news-room/fact-sheets/detail/patient-safety, Accessed December 1, 2019.

Wikispooks: Deep State.
https://wikispooks.com/wiki/Deep_state, Accessed October 1, 2019.

https://tinyurl.com/y7tgwlk3

https://tinyurl.com/y989ucdf

https://tinyurl.com/rtberyh

https://tinyurl.com/y7hrsmj8

https://tinyurl.com/yxbjupfc

https://tinyurl.com/y8u7gf6b

https://tinyurl.com/s6zqhgf

Scientifically proven anticancer products (turmeric, vitamin D, black seed, broccoli, and others)

Wojcik M, Krawczyk M, Wojcik P, Cypryk K, Wozniak LA:
Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer. Oxid Med Cell Longev 2018 2018:9698258.

Unlu A, Nayir E, Dogukan Kalenderoglu M, Kirca O, Ozdogan M:
Curcumin (Turmeric) and cancer. J BUON 2016 21(5):1050-1060.

Hutchins-Wolfbrandt A, Mistry AM:
Dietary turmeric potentially reduces the risk of cancer. Asian Pac J Cancer Prev 2011 12(12):3169-3173.

Mollazadeh H, Afshari AR, Hosseinzadeh H:
Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis: - Black cumin and cancer. J Pharmacopuncture 2017 20(3):158-172.

Majdalawieh AF, Fayyad MW:
Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med 2016 7(3):173-180.

Ahuja A, Kim JH, Kim JH, Yi YS, Cho JY:
Functional role of ginseng-derived compounds in cancer. J Ginseng Res 2018 42(3):248-254.

Mattson MP:
Challenging oneself intermittently to improve health. Dose Response 2014 12(4):600-618.

Ganai SA, Rashid R, Abdullah E, Altaf M:
Plant derived inhibitor sulforaphane in combinatorial therapy against therapeutically challenging pancreatic cancer. Anticancer Agents Med Chem 2017 17(3):365-373.

Greenmedinfo.com

PubMed.gov

Gummin DD, Mowry JB, Spyker DA, Brooks DE, Osterthaler KM, Banner W:
2017 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 35th Annual Report. Clin Toxicol (Phila) 2018, 56(12):1213–1415.

Neuhouser ML, Wassertheil-Smoller S, Thomson C, Aragaki A, Anderson GL, Manson JE, Patterson RE, Rohan TE, van Horn L, Shikany JM,
et al.: Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Arch Intern Med 2009, 169(3):294–304.

Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE:
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2009, 301(1):52–62.

Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM:
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2008, 300(18):2123–2133.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA,
et al.: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009, 301(1):39–51.

Rabin R.C.: Regimens: cancer concerns in big doses of folic acid
http://www.nytimes.com/2009/12/01/health/research/01regi.html

Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C:
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007, 297(8):842–857.

Moderately cold showers are safe and cannot cause an illness

Amsterdam JD, McHenry LB, Jureidini JN:
The effect of cold showering on health and work: A randomized controlled trial. PLoS One 2016, 11(9):e0161749.

Fiore AE, Shay DK, Haber P, Iskander JK, Uyeki TM, Mootrey G, Bresee JS, Cox NJ:
Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007. MMWR Recomm Rep 2007, 56(RR-6):1–54.

Reichert TA, Simonsen L, Sharma A, Pardo SA, Fedson DS, Miller MA:
Influenza and the winter increase in mortality in the United States, 1959–1999. Am J Epidemiol 2004, 160(5):492–502.

Davis MS, Williams CC, Meinkoth JH, Malayer JR, Royer CM, Williamson KK, McKenzie EC:
Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Am J Vet Res 2007, 68(2):185–189.

Shaman J, Kohn M:
Absolute humidity modulates influenza survival, transmission, and seasonality. Proc Natl Acad Sci U S A 2009, 106(9):3243–3248.

The adapted cold shower: an unstressful and easy procedure

Shevchuk NA, Radoja S:
Possible stimulation of antitumor immunity using repeated cold stress: a hypothesis. Infect Agent Cancer 2007, 2:20.

van der Heijden AG, Dewhirst MW:
Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. Int J Hyperthermia 2016 32(4):434-445.

Ahmed K, Zaidi SF:
Treating cancer with heat: hyperthermia as promising strategy to enhance apoptosis. J Pak Med Assoc 2013 63(4):504-508.

Hoption Cann SA, van Netten JP, van Netten C:
Dr William Coley and tumour regression: a place in history or in the future. Postgrad Med J 2003 79:672-680.

Kucerova P, Cervinkova M:
Spontaneous regression of tumour and the role of microbial infection--possibilities for cancer treatment. Anticancer Drugs 2016 27(4):269-277.

Thomas JA, Badini M:
The role of innate immunity in spontaneous regression of cancer. Indian J Cancer 2011 48(2):246-251.

The many benefits of adapted cold showers for cancer patients

Reduction of fatigue

Roundy ES, Cooney LD:
Effectiveness of rest, abdominal cold packs, and cold showers in relievng fatigue.Res Q 1968, 39(3):690–695.

Flensner G, Lindencrona C:
The cooling-suit: case studies of its influence on fatigue among eight individuals with multiple sclerosis.J Adv Nurs 2002, 37(6):541–550.

Huttunen P, Kokko L, Ylijukuri V:
Winter swimming improves general well-being.Int J Circumpolar Health 2004, 63(2):140–144.

Vaile J, Halson S, Gill N, Dawson B:
Effect of hydrotherapy on recovery from fatigue. Int J Sports Med 2008, 29(7):539–544.

The anti-fatigue effect of moderate cooling: the evidence, physiological mechanisms and possible implications for the prevention or treatment of CFS. In
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Pratusevich IM, Shustruiskaia LN:
Change in the cortical and subcortical reactions in children during mental fatigue and its elimination by means of cold and muscular work. Gig Sanit 1962, 27:103–109.

Aly MS, Mohamed MI, Rahman TA, Moustafa S:
Studies of contents of norepinephrine and 5-hydroxytryptamine in brain — I. Normal and cold exposure. Comp Biochem Physiol C 1985, 82(1):155–158.

Toh CC:
Effects of temperature on the 5-hydroxytryptamine (serotonin) content of tissues. J Physiol 1960, 151:410–415.

Reduction of pain

Nadler SF, Weingand K, Kruse RJ:
The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner.Pain Physician 2004, 7(3):395–399.

Offenbacher M, Stucki G:
Physical therapy in the treatment of fibromyalgia.Scand J Rheumatol Suppl 2000, 113:78–85.

Mizoguchi H, Narita M, Kampine JP, Tseng LF:
[Met5]enkephalin and delta2-opioid receptors in the spinal cord are involved in the cold water swimming-induced antinociception in the mouse.Life Sci 1997, 61:PL81–PL86.

Hamm RJ, Knisely JS, Lyons CM:
Adaptation of body temperature and nociception to cold stress in preweanling rats. Physiol Behav 1990, 47(5):895–897.

Hua S, Hermanussen S, Tang L, Monteith GR, Cabot PJ:
The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons. Anesth Analg 2006, 103(6):1558–1564.

Metzger D, Zwingmann C, Protz W, Jackel WH:
Whole-body cryotherapy in rehabilitation of patients with rheumatoid diseases—pilot study. Rehabilitation (Stuttg) 2000, 39(2):93–100.

Robbins LD:
Cryotherapy for headache. Headache 1989, 29(9):598–600.

Singh RK, Martinez A, Baxter P:
Head cooling for exercise-induced headache. J Child Neurol 2006, 21(12):1067–1068.

Enhancement of antitumor immunity

Radoja S:
Possible stimulation of anti-tumor immunity using repeated cold stress: a hypothesis. Infect Agent Cancer 2007, 2:20.

Jansky L, Pospisilova D, Honzova S, Ulicny B, Sramek P, Zeman V, Kaminkova J:
Immune system of cold-exposed and cold-adapted humans. Eur J Appl Physiol Occup Physiol 1996, 72(5–6):445–450.

Castellani JW, IK MB, Rhind SG:
Cold exposure: human immune responses and intracellular cytokine expression. Med Sci Sports Exerc 2002, 34(12):2013–2020.

Banerjee SK, Aviles H, Fox MT, Monroy FP:
Cold stress-induced modulation of cell immunity during acute Toxoplasma gondii infection in mice. J Parasitol 1999, 85(3):442–447.

Reduction of nausea

Chambers JB, Williams TD, Nakamura A, Henderson RP, Overton JM, Rashotte ME:
Cardiovascular and metabolic responses of hypertensive and normotensive rats to one week of cold exposure.Am J Physiol Regul Integr Comp Physiol 2000, 279(4):R1486–R1494.

Bing C, Frankish HM, Pickavance L, Wang Q, Hopkins DF, Stock MJ, Williams G:
Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY.Am J Physiol 1998, 274(1 Pt 2):R62–R68.

Young BA:
Cold stress as it affects animal production. J Anim Sci 1981, 52(1):154–163.

Holloszy JO, Smith EK:
Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory.” J Appl Physiol 1986, 61(5):1656–1660.

Jansky L, Janakova H, Ulicny B, Sramek P, Hosek V, Heller J, Parizkova J:
Changes in thermal homeostasis in humans due to repeated cold water immersions. Pflugers Arch 1996, 432(3):368–372.

Vybiral S, Lesna I, Jansky L, Zeman V:
Thermoregulation in winter swimmers and physiological significance of human catecholamine thermogenesis. Exp Physiol 2000, 85:321–326.

Gonella S, Berchialla P, Bruno B, Di Giulio P:
Are orange lollies effective in preventing nausea and vomiting related to dimethyl sulfoxide? A multicenter randomized trial. Support Care Cancer 2014, 22(9):2417-2424.

Improvement of mood

Rymaszewska J, Ramsey D, Chladzinska-Kiejna S:
Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders.Arch Immunol Ther Exp (Warsz) 2008, 56(1):63–68.

Berger BG, Owen DR:
Mood alteration with swimming—swimmers really do “feel better.” Psychosom Med 1983, 45(5):425–433.

Adapted cold shower as a potential treatment for depression. Med Hypotheses 2008, 70(5):995–1001.

Rymaszewska J, Bialy D, Zagrobelny Z, Kiejna A:
The influence of whole body cryotherapy on mental health. Psychiatr Pol 2000, 34(4):649–653.

Hirvonen J, Lindeman S, Matti J, Huttunen P:
Plasma catecholamines, serotonin and their metabolites and beta-endorphin of winter swimmers during one winter. Possible correlations to psychological traits. Int J Circumpolar Health 2002, 61(4):363–372.

Lindeman S, Hirvonen J, Joukamaa M:
Neurotic psychopathology and alexithymia among winter swimmers and controls—a prospective study. Int J Circumpolar Health 2002, 61(2):123–130.

van Tulleken C, Tipton M, Massey H, Harper CM:
Open water swimming as a treatment for major depressive disorder. BMJ Case Rep 2018, doi: 10.1136/bcr-2018-225007.

Yavari A:
The effect of swimming in reduction of depression in university male students. Research Journal of Biological Sciences 2008, 3(6):543–545.

Rare side effects

Radoja S:
Possible stimulation of anti-tumor immunity using repeated cold stress: a hypothesis. Infect Agent Cancer 2007, 2:20.

Bakst R, Merola JF, Franks AG, Jr., Sanchez M:
Raynaud’s phenomenon: pathogenesis and management. J Am Acad Dermatol 2008, 59(4):633–653.

Julien N, Marchand S:
Endogenous pain inhibitory systems activated by spatial summation are opioid-mediated. Neurosci Lett 2006, 401(3):256–260.

Misasi S, Morin G, Kemler D, Olmstead PS, Pryzgocki K:
The effect of a toe cap and bias on perceived pain during cold water immersion. J Athl Train 1995, 30(1):49–52.

Day MP:
Hypothermia: a hazard for all seasons. Nursing 2006, 36(12 Pt.1):44–47.

McCullough L, Arora S:
Diagnosis and treatment of hypothermia. Am Fam Physician 2004, 70(12):2325–2332.

Doufas AG, Sessler DI:
Physiology and clinical relevance of induced hypothermia. Neurocrit Care 2004, 1(4):489–498.

Tikuisis P:
Heat balance precedes stabilization of body temperatures during cold water immersion. J Appl Physiol 2003, 95(1):89–96.

Milo-Cotter O, Setter I, Uriel N, Kaluski E, Vered Z, Golik A, Cotter G:
The daily incidence of acute heart failure is correlated with low minimal night temperature: cold immersion pulmonary edema revisited? J Card Fail 2006, 12(2):114–119.

Myint PK, Vowler SL, Woodhouse PR, Redmayne O, Fulcher RA:
Winter excess in hospital admissions, in-patient mortality and length of acute hospital stay in stroke: a hospital database study over six seasonal years in Norfolk, UK. Neuroepidemiology 2007, 28(2):79–85.

Sheth T, Nair C, Muller J, Yusuf S:
Increased winter mortality from acute myocardial infarction and stroke: the effect of age. J Am Coll Cardiol 1999, 33(7):1916–1919.

Doubt TJ, Mayers DL, Flynn ET:
Transient cardiac sinus dysrhythmia occurring after cold water immersion. Am J Cardiol 1987, 59(15):1421–1422.

Houdas Y, Deklunder G, Lecroart JL:
Cold exposure and ischemic heart disease. Int J Sports Med 1992, 13(Suppl 1):S179–S181.

Lader EW, Kronzon I:
Ice-water-induced arrhythmias in a patient with ischemic heart disease. Ann Intern Med 1982, 96(5):614–615.

Holloszy JO, Smith EK:
Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory.” J Appl Physiol 1986, 61(5):1656–1660.

Jansky L, Sramek P, Savlikova J, Ulicny B, Janakova H, Horky K:
Change in sympathetic activity, cardiovascular functions and plasma hormone concentrations due to cold water immersion in men. Eur J Appl Physiol Occup Physiol 1996, 74(1–2):148–152.

Roeggla M, Roeggla G, Seidler D, Muellner M, Laggner AN:
Self-limiting pulmonary edema with alveolar hemorrhage during diving in cold water. Am J Emerg Med 1996, 14(3):333.

Biswas R, Shibu PK, James CM:
Pulmonary oedema precipitated by cold water swimming. Br J Sports Med 2004, 38(6):e36.

Wilmshurst PT:
Pulmonary oedema induced by emotional stress, by sexual intercourse, and by exertion in a cold environment in people without evidence of heart disease. Heart 2004, 90(7):806–807.

Arican N, Kaya M, Kalayci R, Kucuk M, Cimen V, Elmas I:
Effects of acute cold exposure on blood-brain barrier permeability in acute and chronic hyperglycemic rats. Forensic Sci Int 2002, 125(2–3):137–141.

Ben-Nathan D, Lustig S, Danenberg HD:
Stress-induced neuroinvasiveness of a neurovirulent noninvasive Sindbis virus in cold or isolation subjected mice. Life Sci 1991, 48(15):1493–1500.

Ben-Nathan D, Lustig S, Feuerstein G:
The influence of cold or isolation stress on neuroinvasiveness and virulence of an attenuated variant of West Nile virus. Arch Virol 1989, 109(1–2):1–10.

Ben-Nathan D, Lustig S, Kobiler D, Danenberg HD, Lupu E, Feuerstein G:
Dehydroepiandrosterone protects mice inoculated with West Nile virus and exposed to cold stress. J Med Virol 1992, 38(3):159–166.

Wan R, Camandola S, Mattson MP:
Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats. Am J Physiol Heart Circ Physiol 2004, 287(3):H1186–H1193.

Elmas I, Kucuk M, Kalayci RB, Cevik A, Kaya M:
Effects of profound hypothermia on the blood-brain barrier permeability in acute and chronically ethanol treated rats. Forensic Sci Int 2001, 119(2):212–216.

Mahapatra AP, Mallick HN, Kumar VM:
Changes in sleep on chronic exposure to warm and cold ambient temperatures. Physiol Behav 2005, 84(2):287–294.

Flensner G, Lindencrona C:
The cooling-suit: case studies of its influence on fatigue among eight individuals with multiple sclerosis. J Adv Nurs 2002, 37(6):541–550.

Giesbrecht GG, Arnett JL, Vela E, Bristow GK:
Effect of task complexity on mental performance during immersion hypothermia. Aviat Space Environ Med 1993, 64(3 Pt 1):206–211.

Zagnoni PG, Albano C:
Psychostimulants and epilepsy. Epilepsia 2002, 43(Suppl 2):28–31.

O’Brien C, Young AJ, Lee DT, Shitzer A, Sawka MN, Pandolf KB:
Role of core temperature as a stimulus for cold acclimation during repeated immersion in 20 degrees C water. J Appl Physiol 2000, 89(1):242–250.

Holloszy JO, Smith EK:
Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory.” J Appl Physiol 1986, 61(5):1656–1660.

Jansky L, Pospisilova D, Honzova S, Ulicny B, Sramek P, Zeman V, Kaminkova J:
Immune system of cold-exposed and cold-adapted humans. Eur J Appl Physiol Occup Physiol 1996, 72(5–6):445–450.

Jansky L, Sramek P, Savlikova J, Ulicny B, Janakova H, Horky K:
Change in sympathetic activity, cardiovascular functions and plasma hormone concentrations due to cold water immersion in men. Eur J Appl Physiol Occup Physiol 1996, 74(1–2):148–152.

Castellani JW, IK MB, Rhind SG:
Cold exposure: human immune responses and intracellular cytokine expression. Med Sci Sports Exerc 2002, 34(12):2013–2020.

Brief cardio exercise

Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J
A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017). PM R 2017, 9(9S2):S347–S384.

Zimmer P, Schenk A, Kieven M, Holthaus M, Lehmann J, Lövenich L, Bloch W:
Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives. Exerc Immunol Rev 2017, 23:66–81.

LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ:
A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exerc Immunol Rev 2015, 21:144–153.

Rasnick D: The Chromosomal Imbalance Theory of Cancer: The Autocatalyzed Progression of Aneuploidy is Carcinogenesis
CRC Press. 2016, p. 220-240.

Poff AM, Ward N, Seyfried TN, Arnold P, D'Agostino DP:
Non­toxic metabolic management of metastatic cancer in VM mice: novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy. PLoS One 2015, 10(6):e0127407.

da Silva I, da Costa Vieira R, Stella C, Loturco E, Carvalho AL, Veo C, Neto C, Silva SM, D'Amora P, Salzgeber M, Matos D, Silva CR, Oliveira JR, Rabelo I, Yamakawa P, Maciel R, Biscolla R, Chiamolera M, Fraietta R, Reis F, Mori M, Marchioni D, Carioca A, Maciel G, Tomioka R, Baracat E, Silva C, Granato C, Diaz R, Scarpellini B, Egle D, Fiegl H, Himmel I, Troi C, Nagourney R:
Inborn-like errors of metabolism are determinants of breast cancer risk, clinical response and survival: a study of human biochemical individuality. Oncotarget 2018, 9(60):31664-31681.

Burzynski SR:
The present state of antineoplaston research (1). Integr Cancer Ther 2004, 3(1):47–58.

Rasnick D:
Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy. Cancer Genet Cytogenet 2002, 136(1):66–72.

Various raw diets for losing overweight and tumors

Cancer can be cured without drugs. Lubodar.info

Brenda Davis
Raw food diets: myths and reality.

Riss DC, Busse CD:
Fifty-day observation of a free-ranging adult male chimpanzee. Folia Primatol (Basel) 1977, 28(4):283–297.

Watts DP:
Scavenging by chimpanzees at Ngogo and the relevance of chimpanzee scavenging to early hominin behavioral ecology. J Hum Evol 2008, 54(1):125–133.

Teelen S:
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US National Cancer Institute: Chemicals in Meat Cooked at High Temperatures and Cancer Risk,
http://www.cancer.gov/about-cancer/causes-prevention/risk/diet/cooked-meats-fact-sheet

Statistical association of cooked meat and cancer:
http://pubmed.gov/26666579
http://pubmed.gov/26505173
http://pubmed.gov/26305323
http://pubmed.gov/25846122
http://pubmed.gov/25583132
http://pubmed.gov/24898235
http://pubmed.gov/24775061
http://pubmed.gov/23011480
http://pubmed.gov/22132129

US Food and Drug Administration: Kinetics of Microbial Inactivation for Alternative Food Processing Technologies,
http://www.fda.gov/Food/FoodScienceResearch/SafePracticesforFoodProcesses/ucm100158.htm

Poff AM, Ward N, Seyfried TN, Arnold P, D'Agostino DP:
Non­toxic metabolic management of metastatic cancer in VM mice: novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy. PLoS One 2015, 10(6):e0127407.

Jallut O:
Instinct therapy—raw food with meat with exclusion of milk products. Report No. 16.Schweiz Rundsch Med Prax 1989, 78(24):697–701.

The importance of organ meats: the pancreas, liver, and thymus

 Rothman S, Liebow C, Isenman L.
Conservation of digestive enzymes. Physiol Rev 2002, 82(1):1-18.

55 ways to change your lifestyle for health improvement

Calabrese EJ, Mattson MP: How does hormesis impact biology, toxicology, and medicine? NPJ Aging Mech Dis 2017, 3:13.

Turner KA: Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors. Ph.D. dissertation, University of California at Berkeley. 2010, 98 pp.

Search the database of radical remissions: https://radicalremission.com/search/

Challis GB, Stam HJ: The spontaneous regression of cancer: a review of cases from 1900 to 1987. Acta Oncologica 1990 29:545-550.

O'Regan B, Hirschberg C: Spontaneous remission: an annotated bibliography. Sausalito: Institute of Noetic Sciences. 713 pp.

Herreros-Villanueva M, Hijona E, Cosme A, Bujanda L: Spontaneous regression of pancreatic cancer: real or a misdiagnosis? World J Gastroenterol 2012 18(23):2902-2908.

Abdelrazeq AS: Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005. Int J Colorectal Dis 2007 22(7):727-736.

Chang WY: Complete spontaneous regression of cancer: four case reports, review of literature, and discussion of possible mechanisms involved. Hawaii Med J 2000 59(10):379-387.

Papac RJ: Spontaneous regression of cancer: possible mechanisms. In Vivo 1998 12(6):571-578.

Point # 1

Jarrett B, Bloch GJ, Bennett D, Bleazard B, Hedges D: The influence of body mass index, age and gender on current illness: a cross-sectional study. Int J Obes (Lond) 2010, 34(3):429–436.

Point # 3

Adapted cold shower as a potential treatment for depression. Med Hypotheses 2008, 70(5):995–1001.

The anti-fatigue effect of moderate cooling: the evidence, physiological mechanisms and possible implications for the prevention or treatment of CFS. In Chronic Fatigue Syndrome: Symptoms, Causes and Prevention. Edited by Svoboda E. and Zelenjcik K.; New York: Nova Science Publishers; 2010; pp. 57–88.

Forrester JM: The origins and fate of James Currie’s cold water treatment for fever. Med Hist 2000, 44(1):57–74.

Stitt JT, Shimada SG: The effect of low ambient temperature on the febrile responses of rats to semi-purified human endogenous pyrogen. Yale J Biol Med 1985, 58(2):189–194.

Greenstein G: Therapeutic efficacy of cold therapy after intraoral surgical procedures: a literature review. J Periodontol 2007, 78(5):790–800.

Laureano Filho JR, de Oliveira e Silva ED, Batista CI, Gouveia FM: The influence of cryotherapy on reduction of swelling, pain and trismus after third-molar extraction: a preliminary study. J Am Dent Assoc 2005, 136(6):774–778; quiz 807.

Wright W: Remarks on malignant fevers; and their cure by cold water and fresh air. Lond Med J 1796, 7:109–115.

Mahapatra AP, Mallick HN, Kumar VM: Changes in sleep on chronic exposure to warm and cold ambient temperatures. Physiol Behav 2005, 84(2):287–294.

Flensner G, Lindencrona C: The cooling-suit: case studies of its influence on fatigue among eight individuals with multiple sclerosis. J Adv Nurs 2002, 37(6):541–550.

Giesbrecht GG, Arnett JL, Vela E, Bristow GK: Effect of task complexity on mental performance during immersion hypothermia. Aviat Space Environ Med 1993, 64(3 Pt 1):206–211.

Pratusevich IM, Shustruiskaia LN: Change in the cortical and subcortical reactions in children during mental fatigue and its elimination by means of cold and muscular work. Gig Sanit 1962, 27:103–109.

Roundy ES, Cooney LD: Effectiveness of rest, abdominal cold packs, and cold showers in relievng fatigue. Res Q 1968, 39(3):690–695.

Huttunen P, Kokko L, Ylijukuri V: Winter swimming improves general well-being. Int J Circumpolar Health 2004, 63(2):140–144.

Vaile J, Halson S, Gill N, Dawson B: Effect of hydrotherapy on recovery from fatigue. Int J Sports Med 2008, 29(7):539–544.

Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil 1984, 65(3):135–138.

Bandelow S, Maughan R, Shirreffs S, Ozgunen K, Kurdak S, Ersoz G, Binnet M, Dvorak J: The effects of exercise, heat, cooling and rehydration strategies on cognitive function in football players. Scand J Med Sci Sports 2010, 20(Suppl 3):148–160.

Berger BG, Owen DR: Mood alteration with swimming—swimmers really do “feel better.” Psychosom Med 1983, 45(5):425–433.

Rymaszewska J, Bialy D, Zagrobelny Z, Kiejna A: The influence of whole body cryotherapy on mental health. Psychiatr Pol 2000, 34(4):649–653.

Hirvonen J, Lindeman S, Matti J, Huttunen P: Plasma catecholamines, serotonin and their metabolites and beta-endorphin of winter swimmers during one winter. Possible correlations to psychological traits. Int J Circumpolar Health 2002, 61(4):363–372.

Lindeman S, Hirvonen J, Joukamaa M: Neurotic psychopathology and alexithymia among winter swimmers and controls—a prospective study. Int J Circumpolar Health 2002, 61(2):123–130.

Rymaszewska J, Ramsey D, Chladzinska-Kiejna S: Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders. Arch Immunol Ther Exp (Warsz) 2008, 56(1):63–68.

Korhonen I: Blood pressure and heart rate responses in men exposed to arm and leg cold pressor tests and whole-body cold exposure. Int J Circumpolar Health 2006, 65(2):178–184.

Diamond S, Freitag FG: Cold as an adjunctive therapy for headache. Postgrad Med 1986, 79(1):305–309.

Nadler SF, Weingand K, Kruse RJ: The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner. Pain Physician 2004, 7(3):395–399.

Hamm RJ, Knisely JS, Lyons CM: Adaptation of body temperature and nociception to cold stress in preweanling rats. Physiol Behav 1990, 47(5):895–897.

Hua S, Hermanussen S, Tang L, Monteith GR, Cabot PJ: The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons. Anesth Analg 2006, 103(6):1558–1564.

Offenbacher M, Stucki G: Physical therapy in the treatment of fibromyalgia. Scand J Rheumatol Suppl 2000, 113:78–85.

Metzger D, Zwingmann C, Protz W, Jackel WH: Whole-body cryotherapy in rehabilitation of patients with rheumatoid diseases—pilot study. Rehabilitation (Stuttg) 2000, 39(2):93–100.

Holloszy JO, Smith EK: Longevity of cold-exposed rats: a reevaluation of the “rate-of-living theory.” J Appl Physiol 1986, 61(5):1656–1660.

Chambers JB, Williams TD, Nakamura A, Henderson RP, Overton JM, Rashotte ME: Cardiovascular and metabolic responses of hypertensive and normotensive rats to one week of cold exposure. Am J Physiol Regul Integr Comp Physiol 2000, 279(4):R1486–R1494.

Young BA: Cold stress as it affects animal production. J Anim Sci 1981, 52(1):154–163.

Bing C, Frankish HM, Pickavance L: Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY. Am J Physiol 1998, 274:R62–R68.

Radoja S: Possible stimulation of anti-tumor immunity using repeated cold stress: a hypothesis. Infect Agent Cancer 2007, 2:20.

Point # 7

Parker-Pope T.: Vitamin pills: a false hope? http://www.nytimes.com/2009/02/17/health/17well.html?_r=1

Neuhouser ML, Wassertheil-Smoller S, Thomson C, Aragaki A, Anderson GL, Manson JE, Patterson RE, Rohan TE, van Horn L, Shikany JM, et al.: Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Arch Intern Med 2009, 169(3):294–304.

Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE: Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2009, 301(1):52–62.

Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM: Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 2008, 300(18):2123–2133.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, et al.: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009, 301(1):39–51.

Rabin R.C.: Regimens: cancer concerns in big doses of folic acid http://www.nytimes.com/2009/12/01/health/research/01regi.html

Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007, 297(8):842–857.

Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR, Jr.: Dietary supplements and mortality rate in older women: the Iowa Women’s Health Study. Arch Intern Med 2011, 171(18):1625–1633.

Klein EA, Thompson IM, Jr., Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, et al.: Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011, 306(14):1549–1556.

Point # 8

Martin CR, Osadchiy V, Kalani A, Mayer EA: The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol 2018, 6(2):133–148.

Hydrotherapy as a possible neuroleptic and sedative treatment. Med Hypotheses 2008, 70(2):230–238.

PDQ Integrative, Alternative, and Complementary Therapies Editorial Board: Gerson Therapy (PDQ®): Health Professional Version. PDQ Cancer Information Summaries 2002–2016, April 11.

Point # 11

Nardi AE, Nascimento I, Valenca AM, Lopes FL, Mezzasalma MA, Zin WA: Panic disorder in a breath-holding challenge test: a simple tool for a better diagnosis. Arq Neuropsiquiatr 2003, 61(3B):718–722.

Austin G: Buteyko technique use to control asthma symptoms. Nurs Times 2013, 109(16):16–17.

Point # 12

Golbidi S, Daiber A, Korac B, Li H, Essop MF, Laher I: Health benefits of fasting and caloric restriction. Curr Diab Rep 2017, 17(12):123.

Matveev VG: Further comment on the precepts of Porfirii Ivanov. Med Sestra 1990, 49:59–60.

Point # 13

Ezzo J, Bausell B, Moerman DE, Berman B, Hadhazy V: Reviewing the reviews. How strong is the evidence? How clear are the conclusions? Int J Technol Assess Health Care 2001, 17(4):457–466.

https://bestpractice.bmj.com/info/evidence-information/ BMJ Best Practice 2018.

Candelario DM, Vazquez V, Jackson W, Reilly T: Completeness, accuracy, and readability of Wikipedia as a reference for patient medication information. J Am Pharm Assoc 2017, 57(2):197–200.e1.

Makary MA, Daniel M: Medical error-the third leading cause of death in the US. BMJ 2016, 353:i2139.

Starfield B: Is US health really the best in the world? JAMA 2000, 284(4):483–485.

Gøtzsche PC: Our prescription drugs kill us in large numbers. Pol Arch Med Wewn 2014, 124(11):628–634.

Kirsch I: The emperor's new drugs: medication and placebo in the treatment of depression. Handb Exp Pharmacol 2014, 225:291–303.

Healy D, Mangin D, Applbaum K, Edwards R, Gallie B, Whitaker R, Le Noury J, Olivieri N: Guides and Papers. Rxisk.org Accessed May 21, 2017.

Gøtzsche PC, Young AH, Crace J: Does long term use of psychiatric drugs cause more harm than good? BMJ 2015, 350:h2435.

Maund E, Tendal B, Hróbjartsson A, Lundh A, Gøtzsche PC: Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study. BMJ 2014, 348:g3555.

Charlton BG: Why are doctors still prescribing neuroleptics? QJM 2006, 99(6):417–420.

Martin JL, Sainz-Pardo M, Furukawa TA, Martín-Sánchez E, Seoane T, Galán C: Benzodiazepines in generalized anxiety disorder: heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol 2007, 21(7):774–782.

Gøtzsche PC: Why Few Patients Benefit from Psychiatric Medications. Madinamerica.com, Continuing Education; Accessed October 14, 2017.

Healy D: Time to abandon evidence-based medicine? YouTube.com, Accessed December 26, 2017.

Lancee M, Lemmens CMC, Kahn RS, Vinkers CH, Luykx JJ: Outcome reporting bias in randomized-controlled trials investigating antipsychotic drugs. Transl Psychiatry 2017, 7(9):e1232.

Amsterdam JD, McHenry LB, Jureidini JN: Industry-corrupted psychiatric trials. Psychiatr Pol 2017, 51(6):993–1008.

Whitaker R: The case against antipsychotic drugs: a 50-year record of doing more harm than good. Med Hypotheses 2004, 62(1):5–13.

Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E: Study 329 continuation phase: Safety and efficacy of paroxetine and imipramine in extended treatment of adolescent major depression. Int J Risk Saf Med 2016, 28(3):143–161.

Le Noury J, Nardo JM, Healy D, Jureidini J, Raven M, Tufanaru C, Abi-Jaoude E: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ 2015, 351:h4320.

Point # 14

Candelario DM, Vazquez V, Jackson W, Reilly T: Completeness, accuracy, and readability of Wikipedia as a reference for patient medication information. J Am Pharm Assoc 2017, 57(2):197–200.e1.

Williams JT: Credible complementary and alternative medicine websites. J Adv Pract Oncol 2013, 4(2):123–124.

Point # 15

Lagisz M, Hector KL, Nakagawa S: Life extension after heat shock exposure: assessing meta-analytic evidence for hormesis. Ageing Res Rev 2013, 12(2):653–660.

Point # 16

https://strelnikova.ru/resultati-issledovanija

Point # 17

Jallut O: Instinct therapy—raw food with meat with exclusion of milk products. Report No. 16. Schweiz Rundsch Med Prax 1989, 78(24):697–701.

Garcia AL, Koebnick C, Dagnelie PC, Strassner C, Elmadfa I, Katz N, Leitzmann C, Hoffmann I: Long-term strict raw food diet is associated with favourable plasma beta-carotene and low plasma lycopene concentrations in Germans. Br J Nutr 2008, 99(6):1293-300.

Point # 18

Dopierała E, Rybakowski J: Sleep deprivation as a method of chronotherapy in the treatment of depression. Psychiatr Pol 2015, 49(3):423–433.

Point # 19

Felton SJ, Cooke MS, Kift R, Berry JL, Webb AR, Lam PM, de Gruijl FR, Vail A, Rhodes LE: Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low-level summer sunlight exposures. Br J Dermatol 2016, 175(6):1320–1328.

Point # 20

Calabrese EJ, Mattson MP: How does hormesis impact biology, toxicology, and medicine? NPJ Aging Mech Dis 2017, 3:13.

Shibamoto Y, Nakamura H: Overview of biological, epidemiological, and clinical evidence of radiation hormesis. Int J Mol Sci 2018, 19(8):2387.

Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDP: Low-fat versus ketogenic diet in parkinson's disease: A pilot randomized controlled trial. Mov Disord 2018, doi: 10.1002/mds.27390

The Gonzalez protocol

Gonzalez NJ. The history of the enzyme treatment of cancer. Altern Ther Health Med 2014, 20(Suppl 2):30-44.

 Gonzalez NJ, Isaacs LL. The Gonzalez therapy and cancer: a collection of case reports. Altern Ther Health Med 2007, 13(1):46-55.

 Saruc M, Standop S, Standop J, Nozawa F, Itami A, Pandey KK, Batra SK, Gonzalez NJ, Guesry P, Pour PM. Pancreatic enzyme extract improves survival in murine pancreatic cancer. Pancreas 2004, 28(4):401-12.

 Gonzalez NJ, Isaacs LL. Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the pancreas, with nutrition and detoxification support. Nutr Cancer 1999, 33(2):117-124.

 Rothman S, Liebow C, Isenman L. Conservation of digestive enzymes. Physiol Rev 2002, 82(1):1-18.

 Gonzalez NJ. The Truth about the NCI-NCCAM Clinical Study https://thegonzalezprotocol.com/research-efforts/nci-nih-funded-clinical-study/, Accessed October 1, 2019.

 Ross CA. Methodological Flaws in the Chabot Trial of Pancreatic Enzymes for Cancer Therapy. ARC Journal of Cancer Science 2015, 1(1):1-4.

 Gonzalez NJ. Enzymes and cancer, https://www.youtube.com/watch?v=fVc8xwr_wfc, Accessed September 20, 2019.

 Mercola J, Gonzalez NJ. On pancreatic cancer of Steve Jobs. https://www.youtube.com/watch?v=kqt3H5YnO1k, Accessed September 20, 2019.

Gonzalez NJ. Why Clinical Trials for Cancer Cures Are Futile. https://www.youtube.com/watch?v=KZrozUfwXn0, Accessed September 20, 2019.

Gonzalez NJ. Conquering Cancer: Volume One 50 Pancreatic and Breast Cancer Patients on the Gonzalez Nutritional Protocol: Volume One. 2016. New Spring Press, 392 pp.

 Gonzalez NJ. Conquering Cancer: Volume Two: 62 Patients on The Gonzalez Protocol. 2017. New Spring Press, 405 pp.

 Gonzalez NJ. One Man Alone: An Investigation of Nutrition, Cancer, and William Donald Kelley. 2010. New Spring Press, 520 pp.

The Revici method and similarities with the Gonzalez protocol

 Revici E:
Research in Physiopathology as a Basis of Guided Chemotherapy With Special Applications to Cancer. 1961, American Foundation for Cancer Research, 600 pp.

 Eidem WK: The Doctor Who Cures Cancer. 2011,
CreateSpace, 402 pp.

Wark C:
How Kelly Healed Cancer plus Sinus Buster for Cancer pain w/ Chris Wark (Chris Beat Cancer), Youtube.com, August 15, 2012.

 Cohen MA: Perpetuating Dr. Revici's Lipid-Based Therapy for Cancer. April 2009,
Townsend's New York Observer, 112-115.

Chida K, Nakanishi K, Shomura H, Homma S, Hattori A, Kazui K, Taketomi A:
Spontaneous regression of transverse colon cancer: a case report. Surg Case Rep 2017, 3(1):65.

Hrobjartsson A, Gotzsche PC:
Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001, 344(21):1594–1602.

Hrobjartsson A, Gotzsche PC:
Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010(1):CD003974.

Llavero-Valero M, Guillén-Grima F, Zafon C, Galofré JC:
The placebo effect in thyroid cancer: a meta-analysis. Eur J Endocrinol 2016, 174(4):465-72.

Ghatalia P, Morgan CJ, Sonpavde G:
Meta-analysis of regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy in prospective trials. Crit Rev Oncol Hematol 2016, 98:122-36.

Pungent chemotherapy

Greenmedinfo.com: Capsaicin, Accessed on December 30, 2019.

Greenmedinfo.com: Ginger, Accessed on December 30, 2019.

Eidem WK: How I Cured Stage 4 Cancer in Two Weeks For Less Than The Cost Of A Night At The Movies, Hubpages.com, Accessed on December 30, 2019.

Nonrecommended alternative treatments of cancer

Hrobjartsson A, Gotzsche PC:
Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001, 344(21):1594–1602.

Hrobjartsson A, Gotzsche PC:
Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010(1):CD003974.

Llavero-Valero M, Guillén-Grima F, Zafon C, Galofré JC:
The placebo effect in thyroid cancer: a meta-analysis. Eur J Endocrinol 2016, 174(4):465-72.

Ghatalia P, Morgan CJ, Sonpavde G:
Meta-analysis of regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy in prospective trials. Crit Rev Oncol Hematol 2016, 98:122-36.

 Gonzalez NJ, Isaacs LL.
The Gonzalez therapy and cancer: a collection of case reports. Altern Ther Health Med 2007, 13(1):46-55.

Conclusions

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Probst P, Grummich K, Harnoss JC, Hüttner FJ, Jensen K, Braun S, Kieser M, Ulrich A, Büchler MW, Diener MK: Placebo-controlled trials in surgery: A systematic review and meta-analysis. Medicine (Baltimore) 2016, 95(17):e3516.

Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M: Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 2011, 305(6):569-575.

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Smith BD, Pan IW, Shih YC, Smith GL, Harris JR, Punglia R, Pierce LJ, Jagsi R, Hayman JA, Giordano SH, Buchholz TA: Adoption of intensity-modulated radiation therapy for breast cancer in the United States. J Natl Cancer Inst 2011, 103(10):798-809.

Prigerson HG, Bao Y, Shah MA, Paulk ME, LeBlanc TW, Schneider BJ, Garrido MM, Reid MC, Berlin DA, Adelson KB, Neugut AI, Maciejewski PK: Chemotherapy Use, Performance Status, and Quality of Life at the End of Life. JAMA Oncol 2015, 1(6):778-784.

Savage P, Stebbing J, Bower M, Crook T: Why does cytotoxic chemotherapy cure only some cancers? Nat Clin Pract Oncol 2009, 6(1):43–52.

Karagiannis GS, Pastoriza JM, Wang Y, Harney AS, Entenberg D, Pignatelli J, Sharma VP, Xue EA, Cheng E, D'Alfonso TM, Jones JG, Anampa J, Rohan TE, Sparano JA, Condeelis JS, Oktay MH: Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med 2017, 9(397):eaan0026.

Morgan G, Ward R, Barton M: The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol) 2004, 16(8):549–560.

Smith TJ, Hillner BE, Desch CE: Efficacy and cost-effectiveness of cancer treatment: rational allocation of resources based on decision analysis. J Natl Cancer Inst 1993, 85(18):1460–1474.

Del Paggio JC, Tannock IF: The fragility of phase 3 trials supporting FDA-approved anticancer medicines: a retrospective analysis. Lancet Oncol 2019, 20(8):1065–1069.

APPENDIX I: 36 ways to distort the results of a clinical trial and cancer statistics

Chida K, Nakanishi K, Shomura H, Homma S, Hattori A, Kazui K, Taketomi A: Spontaneous regression of transverse colon cancer: a case report. Surg Case Rep 2017, 3(1):65.

Hrobjartsson A, Gotzsche PC: Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001, 344(21):1594–1602.

Hrobjartsson A, Gotzsche PC: Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010(1):CD003974.

Llavero-Valero M, Guillén-Grima F, Zafon C, Galofré JC: The placebo effect in thyroid cancer: a meta-analysis. Eur J Endocrinol 2016, 174(4):465-72.

Ghatalia P, Morgan CJ, Sonpavde G: Meta-analysis of regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy in prospective trials. Crit Rev Oncol Hematol 2016, 98:122-36.

Hickey DS, Comp AHD, Noriega LA: The failure of evidence-based medicine? European Journal for Person Centered Healthcare 2013, 1(1):69-79.

Healy D: Time to abandon evidence-based medicine? YouTube.com. Accessed December 26, 2017

George SL: Research misconduct and data fraud in clinical trials: prevalence and causal factors. Int J Clin Oncol 2016, 21(1):15-21.

Angell M: The Truth About The Drug Companies: How They Deceive Us and What To Do About It. 2004. Random House, 352 pp.

Not so bad pharma. David Healy’s review of the book Bad Pharma by Ben Goldacre.

Gonzalez NJ. Why Clinical Trials for Cancer Cures Are Futile. https://www.youtube.com/watch?v=KZrozUfwXn0, Accessed September 20, 2019.

Gonzalez NJ. What Went Wrong: The Truth Behind the Clinical Trial of the Enzyme Treatment of Cancer. 2012. New Spring Press, 616 pp.

User "bonstonthang": Are you a crazy denier of conspiracies? Godlikeproductions.com, August 17, 2019.

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